Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,65V/110V Switchable Glass Smart Film with High Transparency, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump).2019 New Fashion Lace-up Running Sport Casual Shoe“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine(50W/60W Laser Machine with Rotary for Cylinders). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Double Screw Extruder Water-Ring Granulation Line. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC. Its structure is identical if it is derived from bacterial cultures,Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole, or humans.Slim SMD Garden Spotlight LED Floodlight with White Housing. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP).

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Table 1

FDA-OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Porous Vent). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Tungsten Carbide Drill Bushing/Sleeve/Bush.Aluminum Telescopic Flag Pole. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.2019 New Procuct Naural Gas Leak Alarm with Ce ISO®has shown that it also stimulates neocollagenesis (Custom Printed Water Proof Self Adhesive Paper Sticker).

Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wood Sawdust Grinder Wood Powder Making Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (High Purity Melamine 99.8% Min for Plywood).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools. Linear threading, serial puncture, fanning, and cross-hatching,Manufacturer Pneumatic Stainless Steel Angle Seat Valve. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Business Double Sided Card Holder). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (860-960MHz Long Range Reading Security Sealing RFID Tag;Segmented Turbo Cup Grinding Wheel).

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Upper face (Slim SMD Garden Spotlight LED Floodlight with White Housing)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Small or Sachet Pack Instant Tea Juice Powder Packing Machine). However, in cases where the patient has deep glabellar furrows,Rectangle Clear Crystal Wedding Furniture Event Cake Table.Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit.Stock Shoes of Men Work Boot with Steel Toe. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Single Door Upright Glass Door Beverage Display Refrigerator.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Aluminum Telescopic Flag Pole). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler. Injected superficially via serial puncture technique without overcorrection,Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Watertight Aluminum Alloy Brick Wall Expansion Joint Cover-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Alarm System IR+UV Explosion Proof Flame Detector, this area is very prone to significant bruising.

Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment.Polyurethane Rod PU Rod for Machinery and Electronicindustries. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox.Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves(Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Needle Loom Machine Braiding Machine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House, injecting the product as the needle is withdrawn (Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Prefabricated Expandable Modular Container House. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces,Attic Fan-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hotsale Leather Fabric Textile Laser Cutting Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Mobile Phone Holder CO2 Laser Engraving Cutting Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.LED Corn Bulb Light Street Light 2700K-6500K 30W. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.PCB Factory High Precision Prototype PCB and Bulk Production,Nwy Drill Rod with Pin & Box Thread.Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle(0.3-0.8mm White/Walnut Wood Grain Color Painted Aluminum/Aluminium Baffle Ceiling/Grid Coils).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Outstanding Good Design Smooth Action Leather Work Boots-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Direct Factory OEM Plastic Blowing Water Bottle Mould, patients find this defect very unattractive.Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine. It is imperative to review all known potential side effects with the patient before any procedure.

Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China, induration, bruising, tenderness, itching, edema, and erythema at the injection site (High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Mateng 50HP LG Rotary Tiller with 6PCS Blades Per Rotor Piece;30HP High Speed Mixing Machine for Paints and Inks) and, in rare cases, necrosis or embolization might occur (Manufacturer Pneumatic Stainless Steel Angle Seat Valve;China Plant Fiber Bottle). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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