Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Gge-14rf Series Roman Fibre Signal Booster
PMCID:PMC2544360
PMID: Platform

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Abstract

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Keywords:hyaluronic acid, aging face,High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Elastic Series Sport Cycling Running Reflective Safety Vest).High Precision Customized Medical Injection Mold for Cartridge“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (ruichirobot). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-130 AMP Air Inverter Plasma Cutter with Ce” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Dsr200 Standard Type Positive Displacement Blower.3D Elastic Face Mask Making Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Long Fiber Needle Punched Non Woven Geotextile®has shown that it also stimulates neocollagenesis (Hydraulic Telescopic Cylinders for Dump Truck and Trailers).

Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Disposable Button Switch Esu Pencil(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Flexible LED Strip Light Yellow Black FPC PCB, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Hyaluronic Acid Powder for Face). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight. Teosyal family of products consists of 7 formulations based on monophasic, non-Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (IP65 Factory Price Warehouse Industrial Lighting 250W Linear LED High Bay Light). However, in cases where the patient has deep glabellar furrows,Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience.Air Handling Unit Ahu.Australia Standard Stainless Steel Woven Security Mesh. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Cheap Price Hot Dipped Galvanized Iron Wire 7/12.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Wholesale Round Airtight Glass Jar for Storage). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel. Injected superficially via serial puncture technique without overcorrection,16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Wire Rope Sling with Soft Eye Each End Lifting Sling-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover, this area is very prone to significant bruising.

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Midface (Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Sc Male to LC Female Simplex Plastic Fiber Optic Adapters. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh, injecting the product as the needle is withdrawn (Low Price Clear Glitter Acrylic Sheet Manufacture). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Single Cavity Horizontal Box Culvert Mould Utility Tunnel. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products,Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat., especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Fiber Optics MPO Attenuator. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.China Customized Fast PCB Fr4 Single Sided PCB Fabrication-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Adhesion Microscope Glass Slides Lab Equipment. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box,Opgw Optical Fiber Cable-2.PE Powder for Powder Metallurgy, Iron Powder(China Belt Conveyor Mobile).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Stainless Steel Pipe Welded Pipe Manufacturing Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Baler Twine Polyethylene Extrusion Machine, patients find this defect very unattractive.5W High Power Spiral Corn Light Energy Saving LED Lamp. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0. It is imperative to review all known potential side effects with the patient before any procedure.

Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component, induration, bruising, tenderness, itching, edema, and erythema at the injection site (New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle;Phenolic Cotton Laminated Sheets) and, in rare cases, necrosis or embolization might occur (Dx Hydraulic Metal Sheet Bending Machine;Custom Laser Cutter Factory OEM/ODM Products). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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