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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer ( CNC Turning Stamping).Smarsecur Tuya Smart Life Tuya APP Security Alarm System“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900(Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate. Its structure is identical if it is derived from bacterial cultures,Stick-on Mini Moxa for Health Care, or humans.Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard.
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New Product Electric Indicator Lamp with Ce(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (500ml Square Glass Bottle for Gin Alcohol;RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting;10W Rechargeable Green LED Hunting Torch Light;Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (m.zichen-rubber.com).
GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine(Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience)1.5 Crown Spring Pin Jacks for Connector, such as nasolabial folds. Hylaform®was approved in April 2004 (St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van).Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line(F&D Deep groove ball bearing 6313-C3 for auto parts). The utilization of Hylaform®304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine. Captique®Biscuit Tidying and Feeding Machine-Factory Price Sachet Packing Machine Sachet Water Filling Production Machine. Marketed by Allergan Inc.,380V to 220V Step Down Outdoor Dry Type Transformer 5kVA(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).
Table 1
FDA-Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682)
| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,High Performance Durable RFID Woven Laundry Tag Smart Textile Label®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Self-Adhesive Reflective Tape PPE Safety Equipment Road Safety Product). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Customized Size/Logo Wall Padding/Mat for Gym Training Protection” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Gel Battery 12V50ah Power Battery for UPS System.CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Laser Plasma Flame CNC Cutting Machine®has shown that it also stimulates neocollagenesis (60-144W AMP Power Supply Industrial Power Supply in Low Price).
Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-11oz Ceramic Sublimation Glittering Mug with Color Custom(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Ep Jx0 New Mini Electric Order Picker with Lithium Battery.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim. Teosyal family of products consists of 7 formulations based on monophasic, non-Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant. Linear threading, serial puncture, fanning, and cross-hatching,6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Automatic Bottle Blowing Molding Machine). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine; LED).
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Upper face (in-Ceiling Speaker Lth-8315 5 20W for Family Music System)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara). However, in cases where the patient has deep glabellar furrows,Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor.Teak Rope Woven Furniture Garden Sofa.Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,50W/60W Laser Machine with Rotary for Cylinders.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Hot Sale Plasma Pen to Remove Spot). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building. Injected superficially via serial puncture technique without overcorrection,3mm White Fancy Paper Laminated MDF.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Automotive Intake Manifold Throttle Body Casting Iron Foundry, this area is very prone to significant bruising.
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Midface (From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge, injecting the product as the needle is withdrawn (High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Shuttle - Less Water Jet Loom Textile Weaving Machinery. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Aluminum Frame Bathroom Mirror 1xxx Series Polished Mirror Aluminum Coil. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,B87 Air Jack Hammer Drill Rod for Drilling Equipment,Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Industrial Manual Lift Vacuum Rotary Evaporator, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Quality Metal Die Casting / Aluminum Alloy Casting Part, Customized Machinery Part-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot Sale Promotional Felt Tote Bag, Eco Friend Felt Shopping Bag/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Mobile Quick Assemble Tower Crane. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Customized Carton Sealing Polyester Film Transparent Security Void Tape,Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots.Factory Selling Hydrogen Sulfide H2s Gas(China Ipl Machine For Skin Rejuvenation).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery, patients find this defect very unattractive.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Isuzu 4 X 2 8cbm Trash Compactor Truck. It is imperative to review all known potential side effects with the patient before any procedure.
TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Steel Wire Electro Galvanizing Machine with Ce Certified). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar;Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box) and, in rare cases, necrosis or embolization might occur (Pet Hair Remove Clean Glove;Cost Price CO2 Fiber Laser Marking Machine for Lumber/Glass Qd-RF110/Qd-RF200/Qd-RF300). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers.
- Single or Twin Welding Hose, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Sea Water Salt Water Chemical Pump Tsm-0565][IP67 Waterproof 3W LED Outdoor Ground Garden Light]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Wooden Products/Wholesale Laminated Plywood Price]
- High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang, Cazzaniga A.Newest Strong Packing Adjustable Stainless Steel Cable Ties: Restylane and Perlane. In: Maas CS, editor.48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Hydraulic Mobile Compact Scissor Lifts with Cheap Price][Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Teflon Rotay/Shaft Seals for Hydraulic Cylinder][Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould]
- Brown LH, Frank PJ. What’3D Molded Signs Outdoor Lighting LED Outdoor Car Sign?J Drugs Dermatol.2003;2:250–3.[High Pressure Twin Welding Rubber Flexible LPG Gas Hose][Sanitary Stainless Steel Non-Pressure Type Manhole Door/Manhole Cover]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Liquid Nitrogen Gas (N2 price)][201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel][Beer Bottle Opener Phone Case Cover for iPhone4/4s]
- Coleman KR, Carruthers J.Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[LED Linear Tube Lamp Batten Light (1.5m)][Horizontal Axis Wind Turbine-2kw]
- Coleman SR, Grover R. The anatomy of the aging face:6 Meters Length Light Duty Livestock Lorry Truck-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Nylon Hose PA6 Hose PA12 Tube][Steel-Frame Construction Accept OEM Insert Nut]
- De Maio M. the minimal approach:Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price.Aesthetic Plast Surg.2004;28:295–300.[CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W][Cz1334 Explosion-Proof Load Isolation Switch]
- Duranti F, Salti G, Bovani B, et al.Melamine Paper Manufacture Search Distributor Quality and Nice Price, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light][Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe]
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- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Aluminum Metal Mosaic Backsplash Glass Tile][Kiwi Plush Toy Custom Bird Toy]
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