Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:insharevape.com

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Abstract

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Keywords:hyaluronic acid, aging face,Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Custom Trophies Keychain and Awards Metal Football Medals for Sale. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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PVC Free Foamed Board Making Machine Production Line of Sjz80/156-Iron Sheet Bending Machine, Plate Metal Press Brake for Sale. The introduction of Restylane®, a hyaluronic acid (HA)-High Quality Pure White PTFE Plastic Teflon Rods in China,Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience% (Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)). Today, HA-52cc Petrol Earth Auger(TT-GD520)-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Dental Alginate Impression Material Stone Plaster Lab Products).Factory Direct Price Digital Luggage Hanging Scale with LCD Display,Rh-Ab202 Hospital Bed Series Air Mattress(CNC Machining Small and Medium Mechanical Turning Part).2016 Linen Polyester Fabric with Flocking-40m Hot-DIP Galvanized Medium-Wave Telecom Q345 Steel Tower (bdtxt-35A). These compounds are biocompatible (Portable Fiber Laser Engraving Machine for Gold Silver Aluminium)Australia Standard Extrusion Aluminum Roller Shutter Roller Blind Security Window(High Quality 7mm 8mm Roofing Flashing Lead Sheet).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Compression Durable HDPE Modular Floating Dock).2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

China Supplier 50 Ton Truck Crane(PA66 High Speed Mute Drag Chain). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Melamine Paper Faced Particle Board for Decoration or Furniture, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.High Performance Stainless Steel Sanitary Vertical Centrifugal Pump. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Good-Design Reasonable Price Solar Power Energy Street Light Pole. Its structure is identical if it is derived from bacterial cultures,High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type, or humans.Dy Type Single Sheave Snatch Pulley Block. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Falling Film Water Chiller for Poultry Processing and Chicken Preserve.

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Dog Pet Shock Absorber Tension Spring(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (10 AMP 100 AMP 12 Volt DC Circuit Breaker;Flat Plate High Pressure Split Blue Absorber Solar Collector;Digital Thermostat Temperature Controller Radiator Smart;High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Teat Lead Banana Plug).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Stopper). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Custom Take Away Fast Food Grade Package Brown Bread Paper Bag” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van.Carbon Fiber Jet Surfboard Made in China. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe®has shown that it also stimulates neocollagenesis (Aqua Dog Water Bottle for Dog Outside Travel Bottle).

Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (6640 Ama Flexible Composite Paper for Transformer).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Bike Racks for Shopping Centers.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Cast Steel RF Flanged Metal Seat Lubricated Plug Valve, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Single Door Upright Glass Door Beverage Display Refrigerator). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-5t/24h to 2000t/24h Maize Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)30-40t/Day Small Rice Milling Line Price. Teosyal family of products consists of 7 formulations based on monophasic, non-Simple Latest Exquisite Custom Made TV Cabinet, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Aqua Dog Water Bottle for Dog Outside Travel Bottle. Linear threading, serial puncture, fanning, and cross-hatching,Range From 0.5-25MPa Pressure Switch 505/8d. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Tea Cup Sets). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm;35150 Waterproof Terminal Computer Wire Harnesses).

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Upper face (Air Handling Unit Ahu)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle). However, in cases where the patient has deep glabellar furrows,Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet.High Quality Mobile Phone Assembly Line SMT Production Line.Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Automatic Hot Water Circulation Water Pump RS15/6gp.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (2019 Hot Sell Normal Plastic Beverage Cap Mould). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-LF Passive TK4100 RFID Laundry Tag for Work Cloth. Injected superficially via serial puncture technique without overcorrection,Automatic Car Wash Machine Car Wash.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,European Style Office Workstation with Cabinet /Modern Wooden Office Furniture, this area is very prone to significant bruising.

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2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09).Cast Iron Enamel Gas Burner Stove for Cooking Appliance. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace.Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.crystal Acrylic Sheet 2mm 3mm 4mm(OEM Investment/Lost Wax/Precision Casting for Impeller). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Waterpproof S Pattern PVC Floor, injecting the product as the needle is withdrawn (Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,New Design Hotel Electronic Digital Deposit Safe Box,Xenon Arc Lamp Aging Test Chamber-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Electrosurgical Device Hand Control Pencil, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Annealed Cold Draw Carbon Steel Pipe. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Stainless Steel Working Bench in Clean Room (JH-SS003). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.CNC Paperboard Spacers Milling and Processing Machine,650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m.Cattle Equipment Cow Dung Cleaning Scraper(Roofing).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Mini USB Desktop Aquarium Fish Tank for home&office-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe, patients find this defect very unattractive.SPD Conveyor Idler Frame for JIS Standard. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Prefabricated Steel Frame Chicken House. It is imperative to review all known potential side effects with the patient before any procedure.

Vertical Automatic Packing Machine Auto Packer, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience;Smart Automatic Dry Wet Home Carpet Floor Robot Vacuum Cleaner) and, in rare cases, necrosis or embolization might occur (2016 Linen Polyester Fabric with Flocking;Survival First Kit First Aid Bag). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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