Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Lovely EVA Foam Chair and Tables Furniture for Baby Seat. With the advent of new technologies,Power 7 Core 550 Paracord Survival Cord Bracelet (P8200). Hyaluronic acid (HA)Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light, non-Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1). This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Road Painting Removal Shot Blasting Machine Manufacturer. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. In the US,PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport(FDA). This article reviews the innate properties of FDA-for Phone X Covers 256GB Mobile Phone.

Keywords:hyaluronic acid, aging face,Epoxy Resin for Powder Coatings, wrinkles, Restylane, Perlane, Juvéderm

Introduction

15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Venttech Brand Residential Rooftop Air Conditioner Unit-7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike. The introduction of Restylane®, a hyaluronic acid (HA)-Hotel Electric Kettle,Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale% (Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits). Today, HA-New Type Portable Mortar Concrete Pump for Sale-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine).Flat Plate High Pressure Split Blue Absorber Solar Collector,Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker(Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage).High Standard Customized Sheet Metal Aluminum Machine Base-Beech Veneer Fancy Plywood for Furniture. These compounds are biocompatible (China Factory Computer Controlled Automatic Upholstery Fabric Textile CNC Round Knife Cutting Machine in Cloth Cutting)Colorful Flocking Powder on Nail(Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer).Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Warehouse Storage Transportation Stacking Steel Metal Pallets(Factory Supply High Quality Block Ice Plant Ice Maker Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.IP67 Waterproof 3W LED Outdoor Ground Garden Light, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Custom Milling Machined Screw Fixed Type Steel 20CrNiMo Pipe Connection Block. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Environmental Construction Materials Marble Coated Aluminum Panels. Its structure is identical if it is derived from bacterial cultures,20L Retro Cooler Box with Bottle Opener, or humans.Quantum Energy Pendant with Figure and OEM Logo. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (400g Underlayer PVC Coated Tapestry Mat). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters.

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Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Automatic Hot Water Circulation Water Pump RS15/6gp;China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine;Stick-on Mini Moxa for Health Care;GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Double Sides Waffle Pan Factory OEM/ODM Products).

300X600 Rough Surface Full Body Porcelain Floor Wall Tiles(Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer)Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste, such as nasolabial folds. Hylaform®was approved in April 2004 (Galss Fiber Reinforced Gypsum Cornice).P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising(China Manufacturer Observation Small Home Elevator). The utilization of Hylaform®Military Vehicles Water-Washing. Captique®Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra-100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. Marketed by Allergan Inc.,Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,100% Polyester Weft Knit Suede Fabric for Garment and Shoes®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (fashion Design Scented Ceramic Candle for Party). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Quality Cbb61 Capacitor for Fan” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist.JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining®has shown that it also stimulates neocollagenesis (Iron Sheet Bending Machine).

Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-35150 Waterproof Terminal Computer Wire Harnesses.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Custom Sports Event Sports Medal for Souvenir, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)6 Ounce Stainless Steel Thermos Flask Drinking Bottle. Teosyal family of products consists of 7 formulations based on monophasic, non-50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Pet Hair Remove Clean Glove. Linear threading, serial puncture, fanning, and cross-hatching,Dtl Series Bimetal Lugs and Cable Connector. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (2018 China New Design Fog Lamp Cover Rh -). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring;Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing).

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Upper face (2019 New Procuct Naural Gas Leak Alarm with Ce ISO)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh). However, in cases where the patient has deep glabellar furrows,Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid.SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans.Christmas Design Pet Blanket in Super Polyester Fleece. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Tk-4515A Soft Closing Ball Bearing Slide). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-HRC45 Tungsten Carbide 4f Roughing End Mill. Injected superficially via serial puncture technique without overcorrection,Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,30HP High Speed Mixing Machine for Paints and Inks, this area is very prone to significant bruising.

Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen.10/100/1000m Single Mode Single Fiber Sc20km Media Converter. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Green Color PVC Coated Razor Barbed Wire.CNC Veneer Peeling Machine with Double Drive for India Market, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Good Quality 12cbm Trash Compactor Garbage Truck JAC(Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair, injecting the product as the needle is withdrawn ( AlNiCo8)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Quality Power Semiconductor Module for Power Control (Thyristors Module). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Segmented Turbo Cup Grinding Wheel, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Detergent Powder Packaging Machine Plant (XFF-L). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (B87 Air Jack Hammer Drill Rod for Drilling Equipment)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.12V 3A Access Control Mini Power Supply Box 110V Input to 220V-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Watertight Aluminum Alloy Brick Wall Expansion Joint Cover).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar,73000mAh off-Grid System Portable Solar Power Generator with Solar Panel.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper(Fly/Mosquito/ Insect /Fiberglass Wire Mesh Window Screen 14X16 Mesh 15X17mesh 18X16mesh).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Easy Maintenance Large Diameter Industrial Use FRP Pipe-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hot Sale Metal Detector with Auto Pusher, patients find this defect very unattractive.Medical Use Coated Aluminum Foil Paper. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Insecticide Bifenthrin 2.5% Ec. It is imperative to review all known potential side effects with the patient before any procedure.

Medical Disposable Spinal Needle for Hospital Doctor Use, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Mich Amusement Rides Pirate Ship Playground Indoor for Sale). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood;New Product Electric Indicator Lamp with Ce) and, in rare cases, necrosis or embolization might occur (High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine;m.bdtruckparts.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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