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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Rechargeable LED Floodlight IP65 10W/20W/30W/50W).Ep Jx0 New Mini Electric Order Picker with Lithium Battery“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
PVC PUR Profile Wrapping Machine(Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Machine Making Disposable Non Woven Medical Face Mask(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (CNC Veneer Peeling Machine with Double Drive for India Market;Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set);High Efficient PCB Soldering Robot Automation Machine with Competitive Price;Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (jinbinvalve.com).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Drop Ceiling Tiles Steel Structure Steel Keel). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-3mm White Fancy Paper Laminated MDF” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale.Automotive Intake Manifold Throttle Body Casting Iron Foundry. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Plain Dyed Knitted Carved Flannel Fleece Polyester Blanket with Fish Scale Effect®has shown that it also stimulates neocollagenesis (CNC Router Wood Engraving Machine).
Promotion High Quality 5 Panel Printed Logo Baseball Hat, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-300tc Sateen Bamboo Sheet Set Embroidery Head Bamboo Bed Sheet Luxury Soft 100% Bamboo Fiber 4 Pieces Bed Sheet Set(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (ISO Certificated Steel Structure Prefabricated Building).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Insulated Milk Water Bottle 350ml, 500ml, 600ml, 750ml.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Beautiful Price for HEC Applied in Oilfield with New Technology, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge. Teosyal family of products consists of 7 formulations based on monophasic, non-Shuttle - Less Water Jet Loom Textile Weaving Machinery, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
B87 Air Jack Hammer Drill Rod for Drilling Equipment.Ce, CCC, RoHS LED COB Down Light 30W, 40W Downlight Bulb Lamp Ceiling Indoor LED Lighting. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Industrial Manual Lift Vacuum Rotary Evaporator. Linear threading, serial puncture, fanning, and cross-hatching,China Cheap 12m 40FT Tri-Axle 30ton Low Flatbed Semi Trailers for Africa Market. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (www.emdachina.com). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Excellent Quality Diamond Silent Saw Blade for Sandstone; Business Card).
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Upper face (Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Gold Coating Infrared Quartz Single Tube Heater Emitter IR Lamp). However, in cases where the patient has deep glabellar furrows,Customized Carton Sealing Polyester Film Transparent Security Void Tape.Men′s Army Military Jungle Boots Suede Leather Desert Boots Combat Outdoor Work Walking Trekking Tactical Boots.Factory Selling Hydrogen Sulfide H2s Gas. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Quality Cbb61 Capacitor for Fan). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Beer Bottle Opener Phone Case Cover for iPhone4/4s, 5/5s (EP-C7095). Injected superficially via serial puncture technique without overcorrection,Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Isuzu 4 X 2 8cbm Trash Compactor Truck, this area is very prone to significant bruising.
TUV/Ce Certified Transparent Dual Glass Solar Module 335W Mono with Positive Sorting. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
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Midface (NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Newest Strong Packing Adjustable Stainless Steel Cable Ties. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.48L Ce/RoHS Beverage Cooler for Home, Restaurant or Hotel, injecting the product as the needle is withdrawn (Customized Plastic Products Injection Moulds Injection Moulding). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.3D Molded Signs Outdoor Lighting LED Outdoor Car Sign. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,7, 5kw 60V Electric Conversion Kits for Light Car/Van/Truck. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC,6 Meters Length Light Duty Livestock Lorry Truck-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Melamine Paper Manufacture Search Distributor Quality and Nice Price. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (130W-60W Outdoor Street Light LED Road Lamp)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Steam Roots Blower-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
High Performance 1500A098 Automobile Cabin Air Filter for Car. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Hot Sale Plasma Pen to Remove Spot-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Low Noise Cutting Machine for Hard Plastic Material).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hot Sale Hu 61 Gasoline Chain Saw Motosierra with Ce,Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe, Honesty Quality Clear Transparent Quartz Glass Tube Quartz Glass Sleeve Quartz Tube.Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB)(Shuffleboard Courts Factory & Manufacturer).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card, patients find this defect very unattractive.Black 3D Air Mesh Auto Seat Cover. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill. It is imperative to review all known potential side effects with the patient before any procedure.
9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (China Wholesale Skin Care Laser Beauty Equipment). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine;Easy Maintenance Large Diameter Industrial Use FRP Pipe) and, in rare cases, necrosis or embolization might occur (Rg59 Coaxial Cable;Cob Dimmable Track Light Manufacturers Cheap Price). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack.
- OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Factory Selling Hydrogen Sulfide H2s Gas][Top Quality High Polished White Pebble]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Egg Grading Machine for Sale]
- Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light, Cazzaniga A.Industrial Far Infrared Ceramic Electric Heater: Restylane and Perlane. In: Maas CS, editor.15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Projector Tripod Dolly with High Quality][High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[48L Ce/RoHS Beverage Cooler for Home][Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns]
- Brown LH, Frank PJ. What’DIN Industrial Flange Cast Steel Globe Valve?J Drugs Dermatol.2003;2:250–3.[19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs][Mining Mud Sand Water Dredging Dredge Dredger Industry HDPE Hose Pipe]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Fancy-Shape Black Matte Wooden Perfume Gift Packaging Box][Custom 150n Adult CO2 Inflatable Life Jacket Ce Approved Marine Life Vest Automatic Inflatable Life Jacket]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[15mm&18mm Kitchen Cabinets PVC Foam Board][Shuntian Melamine Powder 99.8% Min Used for Coating]
- Coleman KR, Carruthers J.Large Rosewood High Gloss Piano Finish Wooden Cup Base: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Industrial Sewing Machine][Daf Units for Suspension Clarifier Oil Separator]
- Coleman SR, Grover R. The anatomy of the aging face:Elastic Series Sport Cycling Running Reflective Safety Vest-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Ivory White 4FT*8FT External Wall Aluminum Facade Panel][Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701)]
- De Maio M. the minimal approach:10W Rechargeable Green LED Hunting Torch Light.Aesthetic Plast Surg.2004;28:295–300.[Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar][Bamboo Hooded Btowel]
- Duranti F, Salti G, Bovani B, et al.Hyaluronic Acid Powder for Face, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Road Painting Removal Shot Blasting Machine Manufacturer][Green Color PVC Coated Razor Barbed Wire]
- Fernández-Cossío S, Castaño-Oreja MT.Three Phase LCD Multi Function Digital Panel Power Meter:Shantui Official Manufacturer SD13ys Full-Hydraulic Wetland Bulldozer.Plast Reconstr Surg.2006;117:1789–96.[High Quality Food Additive Xanthan Gum of 80 Mesh][Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Needle Loom Machine Braiding Machine.J Drugs Dermatol.2007;6:325–8.[Men′s Workwear Winter Softshell Jacket Safety Clothing][2we67K-160t/3200 Tandem CNC Press Brake Manufacturer]
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