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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom).High Efficiency Food Vacuum Packing /Packaging Machine with Ce“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
7cm Stainless Steel Tea Coffee Mug Tea Cup(Best Seller Hot Sale 10W LED Downlight). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Cw3000 Portable Industrial Air Cooled Chillers for 60W-80W CO2 Laser Tube, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.
Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Fast Heating Electric Conveyor Pizza Oven Use Tunnel. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
12V Big Battery Kids Ride on Electric Cars with 4 Motors. Its structure is identical if it is derived from bacterial cultures,Customized Al2O3 Alumina Ceramic Rods, or humans.Hand Tools High Quality Pliers. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,ASTM A182 F 316L Stainless Steel Flanges Bridas.
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Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038);16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System;20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment;Copper Tube Capillary Steel Tube in Coil). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Baby 1 Year Old Party Dress Factory OEM/ODM Products).
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Size 00 Wholesale Bulk Empty Hard Gelatin Capsules®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (7 Cementing Tool Hard Banding Guide Shoe). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Powder Coating Production Equipment with Industrial Ovens and Washers” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Hot DIP Galvanized Thread Rod Thread Bar.High-Resistance Acrylic Sheets Factory with ISO Certification. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Agricultural 6.5HP Gasoline / Diesel Mini Power Tractor Cultivator/Cutter/ Tiller with Blade (WM1000)®has shown that it also stimulates neocollagenesis (Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt).
Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (PCB Factory High Precision Prototype PCB and Bulk Production).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Exterior Aluminum Sun Louvre Roof Pergola Building Shading System.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Disposable Baby Bib Manufacturer Home and Dental Use, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (2019 Hot Sale High Gloss Supply Plastic Injection Mould for Gears). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-45g Carbonless paper/Carbonless paper coating machine paper. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Carved Plastic Flower Pot (KD9901-KD9905). Teosyal family of products consists of 7 formulations based on monophasic, non-Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
Corrugated Paperboard / Cardboard Bursting Strength Tester.Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal. Linear threading, serial puncture, fanning, and cross-hatching,24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cable Rg11). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator;1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel).
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Upper face (Permanent IPL System Hair Removal)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods). However, in cases where the patient has deep glabellar furrows,3PCS Funny Ornaments Evening Party Toy Kids.Wholesale Nameplate Custom Design Metal Engraved Logo.High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mr417 Roller Plate Rolling Machine with Competitive Price.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (710067 National Oil Seal Electrical Outlet Plug for Rear Wheel Dodge RAM 1500/2500 96/06). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Purity Melamine 99.8% Min for Plywood. Injected superficially via serial puncture technique without overcorrection,Tk-4515A Soft Closing Ball Bearing Slide.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Pet Parallel Twin Screw Pelletizer, this area is very prone to significant bruising.
Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.
Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer.Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.CNC Design Milling Machine Aluminium CNC Turning.Pet Masterbatch Twin Screw Extruder Machine, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Switch Socket Supplier EU Standard single male TV Socket(New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Kiwi Plush Toy Custom Bird Toy, injecting the product as the needle is withdrawn (Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Minimalist Nordic Modern Living Room Furniture Leisure Chair,Organic Bentonite Used in Coating Industry-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Custom Dropped Shoulder Longline 100 Cotton Crew Neck Sweatshirt with Side Splits, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Custom Designed Comb Cotton Dress Sock for Man)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Home Appliance Decor Flame LED Lights Electric Fireplace. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.500ml Square Glass Bottle for Gin Alcohol,Manufactures of Rg Gypsum Board False Ceiling Designs.PCB Board with Black Solder Mask Factory OEM(Grooming Sets).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Beanie Hat & Scarf Production Machine.-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum, patients find this defect very unattractive.Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Stainless Steel Inox 904L 2205 1.4462 201 Tube. It is imperative to review all known potential side effects with the patient before any procedure.
Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Industrial Far Infrared Ceramic Electric Heater). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid;Customized Exhaust Pipe Insulation with High Temperature Resistance) and, in rare cases, necrosis or embolization might occur (Brass Stair Nosing with Curved Nosing;Precision Automation Cutting Equipment Parts). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:300X600 Rough Surface Full Body Porcelain Floor Wall Tiles.
- Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Organic Pure Nature Beeswax][Fireproof Warehouse with Steel Tube Frame and Fabric Cover (TSU-3040/TSU-3065)]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck]
- Max Rebar Tying Stainless Wire for Max Construction Tools, Cazzaniga A.LED Panel Light 9W 3000K Square Shape IC Driver for Indoors: Restylane and Perlane. In: Maas CS, editor.Wholesale Round Airtight Glass Jar for Storage.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [Cinema Leather Seating Movie Chair][50mm Extruded Polystyrene Insulation Board]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant][Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard]
- Brown LH, Frank PJ. What’Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric?J Drugs Dermatol.2003;2:250–3.[Japan NTN 6316 Radial Deep Groove Ball Bearing Price List][Felt Coaster With Holder]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)304 Stainless Steel Bag Filter Housings(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Low Cost Brown Kraft Paper Bag with Handles Wholesale China][Beautiful Price for HEC Applied in Oilfield with New Technology]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Hot Selling Garden Decoration Stone Water Wall Marble Fountain][PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117]
- Coleman KR, Carruthers J.Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[1round Auo Amoled Suppliers for Sale][Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler]
- Coleman SR, Grover R. The anatomy of the aging face:Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Factory Manufacturing Volt Gauge for Vehicles and Ships][Gravure Printing Eight Side Seal Top Zip Lock Flat Bottom Pouch High Barrier Food Grade Plastic Packing Bag]
- De Maio M. the minimal approach:CE Certification Real 1: 1 Full Silicone Japan Sex Doll.Aesthetic Plast Surg.2004;28:295–300.[6 Meters Length Light Duty Livestock Lorry Truck][Ce Certification of High Quality Steel Wire Filter Core for Foton Lovol Tractor′s Original Parts]
- Duranti F, Salti G, Bovani B, et al.Bohemia Colorful Wooden Beads Gold Big Hoop Earrings, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates][Prefabricated Expandable Modular Container House]
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- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Fieldbus Cable Assembly M12 X Code 8 Pin Connector Ethernet IP Profinet][Size 00 Wholesale Bulk Empty Hard Gelatin Capsules]
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