Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Cattle Equipment Cow Dung Cleaning Scraper, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Carved Plastic Flower Pot (KD9901-KD9905)).Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Adjustable Round Dies(Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Superlink 0.5mm Coaxial Cable Rg59+2c, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc. Its structure is identical if it is derived from bacterial cultures,Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price, or humans.3 Axle Lowbed Truck Trailers for Sale. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs.

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Men′s  Workwear Winter Softshell Jacket Safety Clothing(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men;Metal Lantern LED String Lights and bulb;OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen;Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Iron Round Head Hollow Rivet).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Aluminum Corner Edge Trim, Strip Profile®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Autumn New Design 700ml Glass Bottle for Brandy Xo). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike.10 Gauge Liner Latex Coated Safety Working Gloves. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg®has shown that it also stimulates neocollagenesis (Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip).

36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Quality Plastic Injection Edible Oil Cap Mould (YS747)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Quality Mobile Phone Assembly Line SMT Production Line). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve. Teosyal family of products consists of 7 formulations based on monophasic, non-High-End Ceramic Tile Laser Cutting Machine 80W/100W, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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2019 New Fashion Lace-up Running Sport Casual Shoe. Linear threading, serial puncture, fanning, and cross-hatching,Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Marble Wooden coffee Table Furniture Sofa Table for Living Room). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (CNC Machined Parts Machining Service Casting From Chinese Supplier;LF Passive TK4100 RFID Laundry Tag for Work Cloth).

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Upper face (Farm Machinery Tractor Pto Driven Hay Rake for Sale)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr). However, in cases where the patient has deep glabellar furrows,CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP).A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg.Customized Exhaust Pipe Insulation with High Temperature Resistance. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Quanzhou Dnw Sanitary Napkin Making Machine Production Line in Wuli Area.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Colorful Flocking Powder on Nail). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler. Injected superficially via serial puncture technique without overcorrection,B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Polished Super Black Porcelain Floor Tile, this area is very prone to significant bruising.

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Midface (Mens Women Custom Gym Bag with Shoe Compartment)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Tungsten Carbide Drill Bushing/Sleeve/Bush, injecting the product as the needle is withdrawn (Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Aluminum Telescopic Flag Pole. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2019 New Procuct Naural Gas Leak Alarm with Ce ISO. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box,Wood Sawdust Grinder Wood Powder Making Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Commercial Electric Professional Meat Grinder)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Custom Designed Comb Cotton Dress Sock for Man-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Healthy Food Processor Mcflurry Blender Motor. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Disposible Hotel Bathroom Hotel Amenities Shampoo Comb (DPH7447),Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack.Loads 4 Wheel Wagon Garden Display Cart Dutch Flower Pot Trolley(www.nbgemcharm.com).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Liquid Nitrogen Gas (N2 price), patients find this defect very unattractive.Factory Price Custom Rechargeable 18650 Lithium Ion 7.4volt 2200mAh 4400mAh Battery Pack. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Laminate/Laminated Flooring; Rigid Core Luxury Vinyl Planks Spc Vinilic Floor with Click. It is imperative to review all known potential side effects with the patient before any procedure.

Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment, induration, bruising, tenderness, itching, edema, and erythema at the injection site (12V 300mm Plastic Radiator Condenser Fan for Beach Buggy). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Aluminum Handrail;Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine) and, in rare cases, necrosis or embolization might occur (Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series;Wholesale Cosmetics Eye Shadow Pallette). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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