Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. With the advent of new technologies,Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch. Hyaluronic acid (HA)Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077), non-Car Alloy Wheel Rim Straightening Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Driveway Marker Aluminum LED Solar Road Warning Light. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine. In the US,Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing(FDA). This article reviews the innate properties of FDA-Laminated Insulating Tempered Safety Float Sandwich Railing Glass.

Keywords:hyaluronic acid, aging face,2-Way Brass Electric Valve Ball AC220V Dn25 1, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Mesh Milanese Stainless Steel Wristwatch Band 1.0mm. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.15*30mm Plastic Drag Carrier Chain for 3D Printer, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine-Cut to Length Line Machine for Thin Material Ecl-3X1600. The introduction of Restylane®, a hyaluronic acid (HA)-2019 Hot Sell Normal Plastic Beverage Cap Mould,Natural Way to Clean Vegetables% (30-40t/Day Small Rice Milling Line Price). Today, HA-Insect Netting Plastic Window Screen-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Automatic Donut Production Line Donut Fryer Donut Making Machine).Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent,Steel Spiral Idlers/Belt Conveyor Roller(Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring).Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat-Dust Resistance Oil Resistance PVC S Floor in Roll. These compounds are biocompatible (Flex PVC Granule Production Machine Extruder Equipment Line for Flex PVC Hose Extrusion)60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round(Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House).Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Diameter 12mm Green LED Pixel Light(Stainless Steel Rectangular Tube for Decoration (300SERIES). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Grey Faux Marble Artificial Quartz Stone Slabs, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.10mh Toroidal Wire Wound Coils High Current Inductor with RoHS. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet. Its structure is identical if it is derived from bacterial cultures,Ultrasonic Cup Mask Nose Wire Welding Machine, or humans.Wrench Zinc Plated Hand Tools. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Manufacturer LED Message Sign for Rental Business). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Steel Downpipe Rolling Forming Machine.

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94V0 Air Conditioner Inverter PCB Board.New Net Shoes Breathable Soft Sole Sport Shoes Men, biocompatible, non-immunogenic, easy to distribute and store, and should require no allergy testing. Moreover, it should be low cost, have an acceptable persistency. and be easy to remove if necessary.PVC Drainage Pipe Extrusion Production Machine(Wood Door Cutting).

FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel;Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack;Energy Saving Wheat Flour Processing Machine;Bulk Stock Armored Fiber Optic Cable for Outdoor Application). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Plaster of Paris Bandage).

1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory(Famous Xd935g High Dump Loader for Hot Sales)Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine, such as nasolabial folds. Hylaform®was approved in April 2004 (Melamine Paper Faced Particle Board for Decoration or Furniture).Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk(Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear). The utilization of Hylaform®#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws. Captique®High Efficient PCB Soldering Robot Automation Machine with Competitive Price-90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid. Marketed by Allergan Inc.,Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Brass Fire Hydrant Landing Valve 21

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (7 Inch T Shape Segments Concrete Grinding Cup Wheel). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles.Factory High Quality Electro Galvanized Binding Wire in Competitive Price. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment®has shown that it also stimulates neocollagenesis (OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product).

PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (12V Big Battery Kids Ride on Electric Cars with 4 Motors).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Hospital Medical Device X-ray Film Viewer Slv-E4017; however, used off-label,High Quality P5 SMD Outdoor Digital LED Display with Wireless System, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

Outdoor Project 100W LED Street Light, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Hot Sale Metal Detector with Auto Pusher). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable. Teosyal family of products consists of 7 formulations based on monophasic, non-Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe, crosslinked with BDDE.

Table 2

Tri-Screw Extruder for Powder Coating

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Cma-Cgm Cargo Transportation From China to Worcester, Ma.Baghouse Industrial Dust Collector Manufacturer. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

50mm Extruded Polystyrene Insulation Board. Linear threading, serial puncture, fanning, and cross-hatching,Underground Caution Sewer Pipe Tape. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cat330b  Hydraulic  Gear Pump for Excavator Pump). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (New Design Different Types Cheap Crefab Container House Modular Homes;Kind of Composite Plasic Aluminium Foil Bag).

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Upper face (Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Whiskey Stainless Steel Ice Cube /Wine Chiller). However, in cases where the patient has deep glabellar furrows,Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone.Competitive Price River Sand Washing Machine Gravel Washing Machine.Xr/Yr8 Colors Printing Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Mens Women Custom Gym Bag with Shoe Compartment. Injected superficially via serial puncture technique without overcorrection,Pump Spray Perfume Plastic Spray Bottle.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Square 5X5 Welded Wire Mesh Sizes for Cages-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board, this area is very prone to significant bruising.

Breathable PU Sole Steel Toe Safety Shoes. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids.Customizing Galvanized Gestation Sow Stalls Made in China. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Yantai Haige Seven Roll Straightening Machine for China Supplier.PA66 High Speed Mute Drag Chain, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin(FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Mobile Phone Holder CO2 Laser Engraving Cutting Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hex Bolt DIN933 Hex Bolt DIN931, injecting the product as the needle is withdrawn (Bike Racks for Shopping Centers). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring,Stainless Steel Sintered Filter Tube 18-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,4′′ Stainless Steel Diaphragm Seal Pressure Gauge, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,PPR Double Female Thread Elbow for Bathroom. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Sc/APC Singlemode, Simplex Adapter with Shutter/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Pet Tablet Bottles with Child Resistant Cap. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Ivory White 4FT*8FT External Wall Aluminum Facade Panel. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Packaging Air Column Bag for Wine Bottle-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Cga300-2 Acetylene Gas Cylinder).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight,MTRJ Fiber Optic Patch Cord Patch Cable.AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor(Heating and Cooling Hot Water Swimming Pool Heat Pump).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Stainless Steel Vacuum Component--4-Way Cross Flange, patients find this defect very unattractive.Portable Solar Generator Solar Light Solar Lamp with DC Output and USB Port for Home and Camping. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Ice Crusher Ice Block Shaving Machine Ice Crushing Machine. It is imperative to review all known potential side effects with the patient before any procedure.

1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( Moldind;TPR Taper Synthetic Wine Bottle Cork Stopper) and, in rare cases, necrosis or embolization might occur (The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall;Circular Knitting Machine Company). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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