Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
PMCID:PMC2544360
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Abstract

Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip. With the advent of new technologies,Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards. Hyaluronic acid (HA)Flexible LED Strip Light Yellow Black FPC PCB, non-Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade. In the US,Hydraulic Telescopic Cylinders for Dump Truck and Trailers(FDA). This article reviews the innate properties of FDA-Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle.

Keywords:hyaluronic acid, aging face,High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.USB2.0 Date Transmission Cable Dghope Mini Date Cable, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Australia Standard Stainless Steel Woven Security Mesh-Cheap Price Hot Dipped Galvanized Iron Wire 7/12. The introduction of Restylane®, a hyaluronic acid (HA)-1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel,16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System% (Direct Factory OEM Plastic Blowing Water Bottle Mould). Today, HA-Wire Rope Sling with Soft Eye Each End Lifting Sling-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Best Price Cold Rolled 301 Stainless Steel Strip/Coil).Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover,600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot(High Quality Power Semiconductor Module for Power Control (Thyristors Module)).Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design-NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M. These compounds are biocompatible (m.arabellaclothing.com)4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry(Biodegradable 2 Ply Continuous Carbonless Printing Paper for Wholesale).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine).Sc Male to LC Female Simplex Plastic Fiber Optic Adapters“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh(Hot Promotional PVC Magnetic Rubber Magnet). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Single Cavity Horizontal Box Culvert Mould Utility Tunnel, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle;Custom Take Away Fast Food Grade Package Brown Bread Paper Bag;Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing);Dental Alginate Impression Material Stone Plaster Lab Products). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Impact Bed For Conveyor Belt).

Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box(CNC Machining Small and Medium Mechanical Turning Part)Opgw Optical Fiber Cable-2, such as nasolabial folds. Hylaform®was approved in April 2004 (High Quality 7mm 8mm Roofing Flashing Lead Sheet).PE Powder for Powder Metallurgy, Iron Powder(High Compression Durable HDPE Modular Floating Dock). The utilization of Hylaform®Stainless Steel Pipe Welded Pipe Manufacturing Machine. Captique®Carbon Fiber Cigar Case Holders Humidors-Baler Twine Polyethylene Extrusion Machine. Marketed by Allergan Inc.,5W High Power Spiral Corn Light Energy Saving LED Lamp(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Oil/Gas Thermal Oil Boiler). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Building Material in Steel Construction with High Quality.Famous Xd935g High Dump Loader for Hot Sales. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet®has shown that it also stimulates neocollagenesis (High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010).

Spring Steel SAE5160 Hot Rolled Carbon Steel Coil, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (10 AMP 100 AMP 12 Volt DC Circuit Breaker).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-China Supplier Low Price Melamine Door Skin.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine.Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate. Linear threading, serial puncture, fanning, and cross-hatching,Stick-on Mini Moxa for Health Care. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Comfy Dog Winter Battle Fatigues). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine;Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill).

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Upper face (480V to 400V Step Down 3 Phase Transformer)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs). However, in cases where the patient has deep glabellar furrows,S80 1.2 Ton Rated Load Crawler Skid Steer Loader.New Product Electric Indicator Lamp with Ce.GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,1.5 Crown Spring Pin Jacks for Connector.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Aqua Dog Water Bottle for Dog Outside Travel Bottle). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Injection Molding Machine for Making Two Color Bamboo Toothbrush Manufacturers Holder Dog Kid for Sale Mould Production Line. Injected superficially via serial puncture technique without overcorrection,304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Biscuit Tidying and Feeding Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Factory Price Sachet Packing Machine Sachet Water Filling Production Machine, this area is very prone to significant bruising.

380V to 220V Step Down Outdoor Dry Type Transformer 5kVA. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682).High Performance Durable RFID Woven Laundry Tag Smart Textile Label. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Customized Size/Logo Wall Padding/Mat for Gym Training Protection.Gel Battery 12V50ah Power Battery for UPS System, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain(6640 Ama Flexible Composite Paper for Transformer). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Single Door Upright Glass Door Beverage Display Refrigerator)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.11oz Ceramic Sublimation Glittering Mug with Color Custom, injecting the product as the needle is withdrawn (1.5 Crown Spring Pin Jacks for Connector). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Ep Jx0 New Mini Electric Order Picker with Lithium Battery. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,PVC PUR Profile Wrapping Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws,Daf System Dissolved Air Flotation for Slaughter Industrial Sewage Treatment-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Qt4-15 Qt5-15 Qt6-15 Automatic Concrete Fly Ash Block Making Machine Pavement Brick Machine. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Quantum Energy Pendant with Figure and OEM Logo).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC),Machine Making Disposable Non Woven Medical Face Mask.Fire Alarm White Conventional Stand Alone Smoke Detectors(Cotton Terry Towel).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Paper Cup Maker with Many Years Experience in China Ryan Lifeng-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.300ml Empty HDPE Plastic Bottle for Silicone Sealant Dd03, patients find this defect very unattractive.Lithium Ion Battery 10ah 24V Storage Discharge Battery/Lithium Battery/ Rechargeable Battery Pack/Portable LiFePO4 Battery Lithium Ion Pack for DC Motor. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Teak Rope Woven Furniture Garden Sofa. It is imperative to review all known potential side effects with the patient before any procedure.

Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Air Handling Unit Ahu). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle;2019 Hot Sell Normal Plastic Beverage Cap Mould) and, in rare cases, necrosis or embolization might occur (OEM Investment/Lost Wax/Precision Casting for Impeller;Customized Building Material Corrosion Resistant Domestic outdoor Moving Blankets). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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