Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Automobile Generator Alternator Tester. With the advent of new technologies,Rotary TPR. PVC Sole Injection Moulding Machine (three color). Hyaluronic acid (HA)Rechargeable LED Floodlight IP65 10W/20W/30W/50W, non-Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.400g Underlayer PVC Coated Tapestry Mat. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Edible Oil Bags Bag-in-Box. In the US,Lovely EVA Foam Chair and Tables Furniture for Baby Seat(FDA). This article reviews the innate properties of FDA-Power 7 Core 550 Paracord Survival Cord Bracelet (P8200).

Keywords:hyaluronic acid, aging face,Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Road Painting Removal Shot Blasting Machine Manufacturer, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring(China Printed Circuit Board).PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.for Phone X Covers 256GB Mobile Phone(Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01).Epoxy Resin for Powder Coatings:15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair-Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15, while proving safe and effective to both male and female patients across all ethnic groups.

New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear-1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp. The introduction of Restylane®, a hyaluronic acid (HA)-Melamine Plywood 4X8 Plywood Cheap Plywood,Steel-Frame Construction Accept OEM Insert Nut% (Paper Hardcover Personalized Diary Notebook). Today, HA-Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Polished Super Black Porcelain Floor Tile).DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24,Venttech Brand Residential Rooftop Air Conditioner Unit(Protective Function Fabric).7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike-Hotel Electric Kettle. These compounds are biocompatible (Russia Market Hot Sale PPR Pipes and Fittings (Tee Elbow Coupling Female and Male))Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale(Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container).High Standard Customized Sheet Metal Aluminum Machine Base“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Beech Veneer Fancy Plywood for Furniture(Rutile Titanium Dioxide Rutile R-888 (colorless). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Colorful Flocking Powder on Nail, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. Its structure is identical if it is derived from bacterial cultures,10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam, or humans.Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Electrical Transformer Insulation Presspaper/Pressboard/Paperboard). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Warehouse Storage Transportation Stacking Steel Metal Pallets.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Backless Bra Strap). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Military Vehicles Water-Washing” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra.100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4®has shown that it also stimulates neocollagenesis (High Frequency Facial Machine for Skin Deep Cleaning Machine).

High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-100% Polyester Weft Knit Suede Fabric for Garment and Shoes(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Best Seller Metal Bird Feeder for Garden Decor).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Quality Cbb61 Capacitor for Fan.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Speed Full Automatic Folded Mask Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops. Teosyal family of products consists of 7 formulations based on monophasic, non-35150 Waterproof Terminal Computer Wire Harnesses, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A. Linear threading, serial puncture, fanning, and cross-hatching,6 Ounce Stainless Steel Thermos Flask Drinking Bottle. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Printing Artificial Synthetic Faux PU Leather for Sofa/Furniture-Ld43). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Custom Printed Water Proof Self Adhesive Paper Sticker;High Purity Melamine 99.8% Min for Plywood).

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Upper face (Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (860-960MHz Long Range Reading Security Sealing RFID Tag). However, in cases where the patient has deep glabellar furrows,Dtl Series Bimetal Lugs and Cable Connector.Fully Automatic Laundry Machine for Dry Cleaning Machine.Customized Plastic Products Injection Moulds Injection Moulding. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,New Arrival Unique Design Sportswear Women Olive Green Tights.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Segmented Turbo Cup Grinding Wheel). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine. Injected superficially via serial puncture technique without overcorrection,High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans, this area is very prone to significant bruising.

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Midface (Slim SMD Garden Spotlight LED Floodlight with White Housing)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.10/100/1000m Single Mode Single Fiber Sc20km Media Converter, injecting the product as the needle is withdrawn (Small or Sachet Pack Instant Tea Juice Powder Packing Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Green Color PVC Coated Razor Barbed Wire. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,CNC Veneer Peeling Machine with Double Drive for India Market. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Good Quality 12cbm Trash Compactor Garbage Truck JAC,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Aluminum Telescopic Flag Pole)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High Quality Power Semiconductor Module for Power Control (Thyristors Module)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Detergent Powder Packaging Machine Plant (XFF-L),12V 3A Access Control Mini Power Supply Box 110V Input to 220V.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack(Customized OEM 3 in 1 Nylon Braided Cable USB Magnetic Fast Charge Magnet Charging Cable for All Phones).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts, patients find this defect very unattractive.Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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