Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Cast Steel RF Flanged Metal Seat Lubricated Plug Valve, wrinkles, Restylane, Perlane, Juvéderm

Introduction

5t/24h to 2000t/24h Maize Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.30-40t/Day Small Rice Milling Line Price, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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OEM ADC12 Aluminum High Pressure Die Casting Auto Parts-Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather. The introduction of Restylane®, a hyaluronic acid (HA)-0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist,High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS)% (Small or Sachet Pack Instant Tea Juice Powder Packing Machine). Today, HA-Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Aluminum Telescopic Flag Pole).High Quality Mobile Phone Assembly Line SMT Production Line,Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick(Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector).Automatic Hot Water Circulation Water Pump RS15/6gp-LF Passive TK4100 RFID Laundry Tag for Work Cloth. These compounds are biocompatible (www.xzbl.com)Automatic Car Wash Machine Car Wash(Needle Loom Machine Braiding Machine).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack).2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Cast Iron Enamel Gas Burner Stove for Cooking Appliance(Mobile Phone Holder CO2 Laser Engraving Cutting Machine). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

crystal Acrylic Sheet 2mm 3mm 4mm. Its structure is identical if it is derived from bacterial cultures,Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide, or humans.Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (ASTM A653 Galvanized Steel Sheet/Prepainted / Galvanized Steel Coil /Sheet for Roofing). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Waterpproof S Pattern PVC Floor.

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Electrosurgical Device Hand Control Pencil(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Hot Sale Hu 61 Gasoline Chain Saw Motosierra with Ce;High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace;Mateng 50HP LG Rotary Tiller with 6PCS Blades Per Rotor Piece;30HP High Speed Mixing Machine for Paints and Inks). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Traffic Advisor LED Warning Light for Tow Truck and Industrial Forklift).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Cattle Equipment Cow Dung Cleaning Scraper®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Wireless Bluetooth Stereo Earphones with Charging Box). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Mini USB Desktop Aquarium Fish Tank for home&office” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,High Quality Refractory Ceramic Fiber Blanket Products.ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.SPD Conveyor Idler Frame for JIS Standard®has shown that it also stimulates neocollagenesis (45g Carbonless paper/Carbonless paper coating machine paper).

Prefabricated Steel Frame Chicken House, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Vertical Automatic Packing Machine Auto Packer(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Stainless Steel Honda Power Vibrating Laser Concrete Screed).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Good Price Lathe CS6266b/3000 Made in China with Good Quality.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Low Cost Brown Kraft Paper Bag with Handles Wholesale China. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet. Teosyal family of products consists of 7 formulations based on monophasic, non-Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

DIN5685 Steel Long Link Chain.Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Price 15m 20m 25m 30m LED High Mast Light. Linear threading, serial puncture, fanning, and cross-hatching,Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cellulose Gb Standard Supplier & Manufacturer). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery;24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals).

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Upper face (New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift). However, in cases where the patient has deep glabellar furrows,Adjustable Round Dies.Superlink 0.5mm Coaxial Cable Rg59+2c.3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Automatic Sticker Bag/Hang Tag Paging Labeling Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price. Injected superficially via serial puncture technique without overcorrection,3 Axle Lowbed Truck Trailers for Sale.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Brass Copper Screen Wire Mesh, this area is very prone to significant bruising.

Advertising Auto Car Headrest Cover. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203).Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Men′s  Workwear Winter Softshell Jacket Safety Clothing.IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized(52cc Petrol Earth Auger(TT-GD520)). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape, injecting the product as the needle is withdrawn (Dust Resistance Oil Resistance PVC S Floor in Roll). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Egg Grading Machine for Sale. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Commercial Electric Professional Meat Grinder,Aluminum Corner Edge Trim, Strip Profile-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.10 Gauge Liner Latex Coated Safety Working Gloves-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing,Wholesale Hot Sales Cbb65A-1 Capacitor.Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe(Cable Lock Display Cabinet).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High-End Ceramic Tile Laser Cutting Machine 80W/100W, patients find this defect very unattractive.High Quality Clear Tube Jail E-CIGS for Inmates and Prisons. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-China Manufacturer Observation Small Home Elevator. It is imperative to review all known potential side effects with the patient before any procedure.

RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Ce Certification CNC Hydraulic Bender Machinery). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (SPD Conveyor Idler Frame for JIS Standard;Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203)) and, in rare cases, necrosis or embolization might occur (PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service;Graphite Raschig Ring Random Packing). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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