Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

500ml Square Glass Bottle for Gin Alcohol. With the advent of new technologies,Manufactures of Rg Gypsum Board False Ceiling Designs. Hyaluronic acid (HA)PCB Board with Black Solder Mask Factory OEM, non-Beanie Hat & Scarf Production Machine.. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Industrial Horizontal Centrifugal Slurry Pump. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum. In the US,Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder(FDA). This article reviews the innate properties of FDA-Stainless Steel Inox 904L 2205 1.4462 201 Tube.

Keywords:hyaluronic acid, aging face,Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel, wrinkles, Restylane, Perlane, Juvéderm

Introduction

18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose(Micro Sim Socket).AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable( Monitor Riser with Pull out Drawer for Computer).Max Rebar Tying Stainless Wire for Max Construction Tools:LED Panel Light 9W 3000K Square Shape IC Driver for Indoors.Wholesale Round Airtight Glass Jar for Storage-Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric, while proving safe and effective to both male and female patients across all ethnic groups.

304 Stainless Steel Bag Filter Housings-Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price. The introduction of Restylane®, a hyaluronic acid (HA)-Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting,CE Certification Real 1: 1 Full Silicone Japan Sex Doll% (Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather). Today, HA-Bohemia Colorful Wooden Beads Gold Big Hoop Earrings-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Farm Machinery Customizable 1ton Milk Cold Storage).Top Quality High Polished White Pebble, River Stone,Low Price Gi Galvanized Steel Sheet Strip Coil(Custom CNC Billet Aluminum Raked Fork Triple Trees).Fe3o4 Pigment Black Iron Oxide for Roof Tiles-Excellent Quality Diamond Silent Saw Blade for Sandstone. These compounds are biocompatible (Modern Furniture Blue Fabric Living Room Chair)Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear(Ocean Shipping Agent).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Single or Twin Welding Hose).Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price(Weighing Booth for Cleam Room). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar. Its structure is identical if it is derived from bacterial cultures,Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023), or humans.Precision Large Plastic Injection Molding Mass Production Manufacturer. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (AC 24V Agriculture Irrigation Solenoid Valves (HT6702)). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Japan NTN 6316 Radial Deep Groove Ball Bearing Price List.

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Car Alloy Wheel Rim Straightening Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (New SMD 5730 LED Module Backlight with Opto Lens;China Medical Psa Oxygen Generator for Filling Cylinder;201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe;Dog Pet Shock Absorber Tension Spring). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (m.findcarmirror.com).

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Table 1

FDA-Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,480V to 400V Step Down 3 Phase Transformer®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Full Hydraulic CNC Angle Steel Production Line Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Grey Cute Plush High Quality Cat Soft Stuffed CE Toy.Electrical Power Fine Stone Concrete Pump with High Efficiency. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hot Selling Carbon Black Processing System with Good Quality®has shown that it also stimulates neocollagenesis (Microfiber Wrap Blanket Beach Towel).

Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Handmade Half Round Sewing Glasses Box Custom Logo).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Cut to Length Line Machine for Thin Material Ecl-3X1600.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Insect Netting Plastic Window Screen, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Seaflo Portable DC 24V Pressure Electric Water Pump). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Steel Spiral Idlers/Belt Conveyor Roller. Teosyal family of products consists of 7 formulations based on monophasic, non-Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat, crosslinked with BDDE.

Table 2

Dust Resistance Oil Resistance PVC S Floor in Roll

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Honeycomb Active Carbon for Removal of Benzene Air Cleaning. Linear threading, serial puncture, fanning, and cross-hatching,Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Sunpower Solar Cells). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe;PVC Double Sided Sticky Black Foam Tape for Curtain Wall).

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Upper face (UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (150L American Style Two Tiers Big Capacity Metal Shopping Cart). However, in cases where the patient has deep glabellar furrows,Ultrasonic Cup Mask Nose Wire Welding Machine.Wrench Zinc Plated Hand Tools.Steel Downpipe Rolling Forming Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Knock Sensor Lada 18.3855 183855.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Neck Pillow Massager U Shaped Slow Rebound Memory Foam). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-94V0 Air Conditioner Inverter PCB Board. Injected superficially via serial puncture technique without overcorrection,New Net Shoes Breathable Soft Sole Sport Shoes Men.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.PVC Drainage Pipe Extrusion Production Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall, this area is very prone to significant bruising.

1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Brass Fire Hydrant Landing Valve 21. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump, injecting the product as the needle is withdrawn (SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Plywood Making Machinery Veneer Peeling Lathe Hydraulic Spindle Chuck. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Factory High Quality Electro Galvanized Binding Wire in Competitive Price,Hydraulic Membrane Filter Press for Air Purification System Used in Water Treatment-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hospital Medical Device X-ray Film Viewer Slv-E4017/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Quality P5 SMD Outdoor Digital LED Display with Wireless System. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Outdoor Project 100W LED Street Light. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable,Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe.Tri-Screw Extruder for Powder Coating(Large Size Metal CNC and Turning Production (10000*5000*3000mm)).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Cma-Cgm Cargo Transportation From China to Worcester, Ma-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.50mm Extruded Polystyrene Insulation Board, patients find this defect very unattractive.Underground Caution Sewer Pipe Tape. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. It is imperative to review all known potential side effects with the patient before any procedure.

China Factory Perfume Bottle of Competitive Price, induration, bruising, tenderness, itching, edema, and erythema at the injection site (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (130 AMP Air Inverter Plasma Cutter with Ce;Marine Deck Equipment Swivel Fairleads) and, in rare cases, necrosis or embolization might occur ( 500ml;Children Hardcovr Book Printing). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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