Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Dsr200 Standard Type Positive Displacement Blower. With the advent of new technologies,3D Elastic Face Mask Making Machine. Hyaluronic acid (HA)Long Fiber Needle Punched Non Woven Geotextile, non-Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Disposable Button Switch Esu Pencil. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick. In the US,Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip(FDA). This article reviews the innate properties of FDA-Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards.

Keywords:hyaluronic acid, aging face,Flexible LED Strip Light Yellow Black FPC PCB, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Good Performance Mini Tattoo Removal Beauty Device-F&D Deep groove ball bearing 6313-C3 for auto parts. The introduction of Restylane®, a hyaluronic acid (HA)-ASTM TM2 Thermal bimetallic strip P675R bimetal strip,Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)% (10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape). Today, HA-Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Sweet Potato Tapioca Cassava Potato Starch Noodle Maker).Air Handling Unit Ahu,Australia Standard Stainless Steel Woven Security Mesh(Adhesion Microscope Glass Slides Lab Equipment).Cheap Price Hot Dipped Galvanized Iron Wire 7/12-1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel. These compounds are biocompatible (30HP Waste Crusher for Plastic Automotive Interior and Exterior Parts)16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System( 5kw 60V Electric Conversion Kits for Light Car/Van/Truck).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler).Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M(Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Light Oil Burner Suitable for Various Kinds of Burners. Its structure is identical if it is derived from bacterial cultures,Optic Fiber Fusion Splicer Waterproof Splice Closure, or humans.Sc Male to LC Female Simplex Plastic Fiber Optic Adapters. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh.

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The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle;Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag; B Shell;Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (www.petnbf.com).

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Table 1

FDA-Opgw Optical Fiber Cable-2

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,PE Powder for Powder Metallurgy, Iron Powder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Man Truck Air Compressor Suction Mini Brake Valve). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Pipe Welded Pipe Manufacturing Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Carbon Fiber Cigar Case Holders Humidors.Baler Twine Polyethylene Extrusion Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.5W High Power Spiral Corn Light Energy Saving LED Lamp®has shown that it also stimulates neocollagenesis (65V/110V Switchable Glass Smart Film with High Transparency).

Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (80kVA Standby 75kVA Prime Power Silent Generator ATS Prefer Cummins).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat.). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Spring Steel SAE5160 Hot Rolled Carbon Steel Coil. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A). Teosyal family of products consists of 7 formulations based on monophasic, non-China Supplier Low Price Melamine Door Skin, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter.Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211. Linear threading, serial puncture, fanning, and cross-hatching,ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Free Stand Digital Signage). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (2019 Hot Selling High Quality CAT6 STP RJ45 Connector;Insect Netting Plastic Window Screen).

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Upper face (High Glossy Printing Materials Backlit Flex Banner Flex Printing Material)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality DTH Button Drill Bits for Mining Machine). However, in cases where the patient has deep glabellar furrows,Stick-on Mini Moxa for Health Care.Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving.Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,96 Cores Fiber Optic Multifiber Breakout Patch Cords.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (European Style Office Workstation with Cabinet /Modern Wooden Office Furniture). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Microwave Small Yellow Croaker Baking Machine. Injected superficially via serial puncture technique without overcorrection,China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.S80 1.2 Ton Rated Load Crawler Skid Steer Loader-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,New Product Electric Indicator Lamp with Ce, this area is very prone to significant bruising.

GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.High Performance Durable RFID Woven Laundry Tag Smart Textile Label, injecting the product as the needle is withdrawn (10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Customized Size/Logo Wall Padding/Mat for Gym Training Protection. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Gel Battery 12V50ah Power Battery for UPS System. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,CCS ABS Lr Dnv Marine Stud Link G3 Anchor Chain,Laser Plasma Flame CNC Cutting Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,11oz Ceramic Sublimation Glittering Mug with Color Custom. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Breathable PU Sole Steel Toe Safety Shoes)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Ep Jx0 New Mini Electric Order Picker with Lithium Battery-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.PVC PUR Profile Wrapping Machine/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim,Automatic Drying Control Hot Air Force Circulation Tunnel Conveyor Furnace.Wholesale Latest Model Cheap Unique Jewelry 925 Sterling Silver CZ Long Earrings for Girls(Heavy Duty Cargo Box Truck).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Impact 15mm Thick HDPE Sheet High Density Polyethylene Sheet-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant, patients find this defect very unattractive.6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Machine Making Disposable Non Woven Medical Face Mask. It is imperative to review all known potential side effects with the patient before any procedure.

Fire Alarm White Conventional Stand Alone Smoke Detectors, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Hex Bolt DIN933 Hex Bolt DIN931;DIN7504 Good Quality Truss Head Self Drilling/Tapping Screws) and, in rare cases, necrosis or embolization might occur (Shuttle - Less Water Jet Loom Textile Weaving Machinery;Cell Phone Spare Parts For Huawei Nova 3e Display Digitizer Screen High Quality Lcd Screen For Huawei P20 Lite Lcd Touch Screen). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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