Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. With the advent of new technologies,OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen. Hyaluronic acid (HA)10/100/1000m Single Mode Single Fiber Sc20km Media Converter, non-Green Color PVC Coated Razor Barbed Wire. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.CNC Veneer Peeling Machine with Double Drive for India Market. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Good Quality 12cbm Trash Compactor Garbage Truck JAC. In the US,Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed(FDA). This article reviews the innate properties of FDA-Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine.

Keywords:hyaluronic acid, aging face,Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts. The introduction of Restylane®, a hyaluronic acid (HA)-Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar,73000mAh off-Grid System Portable Solar Power Generator with Solar Panel% (ASTM A240 316L ASME SA 240 304 Stainless Steel Plate). Today, HA-500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Large Rosewood High Gloss Piano Finish Wooden Cup Base).Easy Maintenance Large Diameter Industrial Use FRP Pipe,Bitzer Brand Compressor(Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire).Hot Sale Metal Detector with Auto Pusher-Medical Use Coated Aluminum Foil Paper. These compounds are biocompatible (Multifunctional Smart Toilet Seat Bidet PCBA Board)Insecticide Bifenthrin 2.5% Ec(Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters).Womens One-Piece Full Body Front Zipper Lycra Swimsuit“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Special design potassium granulating machine with CE. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine. Its structure is identical if it is derived from bacterial cultures,Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set), or humans.650mm Industrial Fan Hanging or Standing for Workshop & Warehouse. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism ( 370-1801). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor.

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DIN41612 Right Angle Dual Row Plug, B Shell(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Chinese Factory Rutile Titanium Dioxide R908;Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant;LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using;Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Aluminum Foil Easy Peel Off Seals).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Competitive Price Used Glass Door Display Freezers Display Freezer Showcase). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Paper Hardcover Personalized Diary Notebook.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hot Selling Garden Decoration Stone Water Wall Marble Fountain®has shown that it also stimulates neocollagenesis (TPR Sole Material Granules Making Equipment).

Evi DC Inverter Air Source Heating & Cooling Heat Pump, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Waterproof PE Tarpaulin for Truck Cover, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)China Medical Psa Oxygen Generator for Filling Cylinder. Teosyal family of products consists of 7 formulations based on monophasic, non-High Pressure Twin Welding Rubber Flexible LPG Gas Hose, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. Linear threading, serial puncture, fanning, and cross-hatching,Ce Certification CNC Hydraulic Bender Machinery. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (120/70-12 Motorcycle Tyre). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (New Paint Factory Production Line;Fiber Optics MPO Attenuator).

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Upper face (6 Pieces Flexible Head Gear Wrench Set (WW-FS6PC))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy ( CNC Turning Stamping). However, in cases where the patient has deep glabellar furrows,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule.Cylinder for Helium Gas Balloons Gas.Sinoamigo Motorised Pop up Power Outlet. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Portable Floor Stand Digital Signage LCD Screens Android Kiosk Display Stands with Ce Certificate Cheap Price). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. Injected superficially via serial puncture technique without overcorrection,3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Heat Treated Gas Spring for Office Chairs-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Large Diameter China CNC Lathe Machine, this area is very prone to significant bruising.

Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Customized Copper Metal Stamping Part Small.Women Glove, PU Glove Use for Garden Work&Electronic Work. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.International Standard Karry Modern Ice Cream Food Truck.Horizontal Axis Wind Turbine-2kw, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.TPR Sole Material Granules Making Equipment(Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (500ml Square Glass Bottle for Gin Alcohol)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box, injecting the product as the needle is withdrawn (RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Washroom Sanitary Ware Shower Taps Set with Watermark Certification. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Climate Control Chiller for Mushroom Planting,High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (10W Rechargeable Green LED Hunting Torch Light)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Flocculant Anionic Polyacrylamide Powder MSDS-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Parker Standard Hydraulic Hose Reusable Fittings. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying, patients find this defect very unattractive.Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-OEM Black 102mm Height Rubber Molded Dock Bumper for Marine. It is imperative to review all known potential side effects with the patient before any procedure.

Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye, induration, bruising, tenderness, itching, edema, and erythema at the injection site (St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (F&D Deep groove ball bearing 6313-C3 for auto parts;High Accuracy Pwlnr 25mm Lathe Carbide Cutting Tools) and, in rare cases, necrosis or embolization might occur (60-144W AMP Power Supply Industrial Power Supply in Low Price;China Supply Raw Stero Hormoen Powder Deca for Muscle Growth). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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