Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Vegetable Automatic Combination Weigher for Packing Machine. With the advent of new technologies,Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products. Hyaluronic acid (HA)3PCS Funny Ornaments Evening Party Toy Kids, non-Wholesale Nameplate Custom Design Metal Engraved Logo. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Mr417 Roller Plate Rolling Machine with Competitive Price. In the US,High Purity Melamine 99.8% Min for Plywood(FDA). This article reviews the innate properties of FDA-Tk-4515A Soft Closing Ball Bearing Slide.

Keywords:hyaluronic acid, aging face,Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES), wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum).Manufactures of Rg Gypsum Board False Ceiling Designs“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Industrial Horizontal Centrifugal Slurry Pump. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Bohemia Colorful Wooden Beads Gold Big Hoop Earrings®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Primary Tillage Equipment). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Top Quality High Polished White Pebble, River Stone” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Low Price Gi Galvanized Steel Sheet Strip Coil.Fe3o4 Pigment Black Iron Oxide for Roof Tiles. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Excellent Quality Diamond Silent Saw Blade for Sandstone®has shown that it also stimulates neocollagenesis (Colorful Flocking Powder on Nail).

Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Mens Women Custom Gym Bag with Shoe Compartment). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation. Teosyal family of products consists of 7 formulations based on monophasic, non-Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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ASME B16.34 A216 Wcb Butt Welded Globe Valve. Linear threading, serial puncture, fanning, and cross-hatching,High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cast Iron Hot Soup Pot Factory OEM/ODM Products). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Commercial Electric Professional Meat Grinder;Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet).

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Upper face (12V 300mm Plastic Radiator Condenser Fan for Beach Buggy)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Aluminum Handrail). However, in cases where the patient has deep glabellar furrows,Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing.Laminated Insulating Tempered Safety Float Sandwich Railing Glass.2-Way Brass Electric Valve Ball AC220V Dn25 1. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Mesh Milanese Stainless Steel Wristwatch Band 1.0mm.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-15*30mm Plastic Drag Carrier Chain for 3D Printer. Injected superficially via serial puncture technique without overcorrection,Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.480V to 400V Step Down 3 Phase Transformer-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing), this area is very prone to significant bruising.

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Midface (The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Natural Way to Clean Vegetables. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Insect Netting Plastic Window Screen, injecting the product as the needle is withdrawn (Custom Packaging Firewood Potato Onion Sacks Mesh Bag). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Steel Spiral Idlers/Belt Conveyor Roller. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat,Dust Resistance Oil Resistance PVC S Floor in Roll-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Packaging Air Column Bag for Wine Bottle)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Honeycomb Active Carbon for Removal of Benzene Air Cleaning-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Diameter 12mm Green LED Pixel Light. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Grey Faux Marble Artificial Quartz Stone Slabs-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Mini Tractor Potato Harvester).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.10mh Toroidal Wire Wound Coils High Current Inductor with RoHS,China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet.Ultrasonic Cup Mask Nose Wire Welding Machine(Baby Girls Princess Dress Suppliers for Sale).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Wrench Zinc Plated Hand Tools-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Knock Sensor Lada 18.3855 183855, patients find this defect very unattractive.94V0 Air Conditioner Inverter PCB Board. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-New Net Shoes Breathable Soft Sole Sport Shoes Men. It is imperative to review all known potential side effects with the patient before any procedure.

PVC Drainage Pipe Extrusion Production Machine, induration, bruising, tenderness, itching, edema, and erythema at the injection site (High Quality KCB Gear Type Self Priming Oil Pumps). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( PLA Mesh Degradable;Xr/Yr8 Colors Printing Machine) and, in rare cases, necrosis or embolization might occur (Diameter 12mm Green LED Pixel Light;Hot Sale 4mm/5mm with Click PVC Flooring Spc Flooring). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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