Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Big Size Hot Sell Particle Board Office Modern Standing Desk. With the advent of new technologies,Premium Quality Aluminum Foil Container for Food Use. Hyaluronic acid (HA)PVC Wall Decoration Panels Ceiling Tiles for South Africa Market DC-117, non-Fengdeng OEM ODM Logo Design Cotton Fashion Designer Women Bag. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Galvanized/PVC Coated Barbed Wire for Prison Security Fence. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,X6132 Horizontal Knee Type Universal Milling Machine for Sale. In the US,CNC Router Wood Engraving Machine(FDA). This article reviews the innate properties of FDA-High Precision Customized Medical Injection Mold for Cartridge.

Keywords:hyaluronic acid, aging face,Silicon Dog Foot Washer Portable Dog Paw Cleaner, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Tzm Black Molybdenum Plates for Vacuum Furnace-Best Quality Alu Tube Filling and Sealing Machine. The introduction of Restylane®, a hyaluronic acid (HA)-Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film,Foam Tube Protective Rubber Foam Tube for Bicycle% (Watertight Aluminum Alloy Brick Wall Expansion Joint Cover). Today, HA-Office Building Commercial Tile Carpet-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Mich Amusement Rides Pirate Ship Playground Indoor for Sale).5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T),860ml Glass Juice Bottles with Tin Lids(Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood).Biomass Material Waste Wood Crusher for Getting Sawdust-Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film. These compounds are biocompatible (Five Star Aluminum Foil Coated Metallic Laminated Nonwoven)New Paint Factory Production Line(New Product Electric Indicator Lamp with Ce).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine).3D Elastic Face Mask Making Machine“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Long Fiber Needle Punched Non Woven Geotextile(Industrial Manual Lift Vacuum Rotary Evaporator). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Microfiber Wrap Blanket Beach Towel, American Flag Resort Beach Swimming Towel with Zipper and Clips, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Disposable Button Switch Esu Pencil. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick. Its structure is identical if it is derived from bacterial cultures,Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip, or humans.Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Water Filling Machines). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Flexible LED Strip Light Yellow Black FPC PCB.

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Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi;High Performance Durable RFID Woven Laundry Tag Smart Textile Label;2019 Tie on Non Woven Disposable Medical Surgical Cap Machine;Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Laser Cut Metal Decorations).

High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine( Cat Collar)BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire, such as nasolabial folds. Hylaform®was approved in April 2004 (Fluorescent Lime-Yellow Fire Retardant Reflective Tape).USB2.0 Date Transmission Cable Dghope Mini Date Cable(Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles). The utilization of Hylaform®Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale. Captique®Good Performance Mini Tattoo Removal Beauty Device-F&D Deep groove ball bearing 6313-C3 for auto parts. Marketed by Allergan Inc.,ASTM TM2 Thermal bimetallic strip P675R bimetal strip(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

FDA-Hybrid Ceramic Stainless Steel Ball Bearing (6803 6804 6806 61803 61804 61806 2RS)

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Fan Remote Control PCB Board DVD Power Board From China Supplier with 20 Years Experience®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Vertical Sump Pump). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Air Handling Unit Ahu” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Australia Standard Stainless Steel Woven Security Mesh.Cheap Price Hot Dipped Galvanized Iron Wire 7/12. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.1.3247/W2mo9cr4vco8/S2-10-1-8/HS2-9-1-8/Skh59/2716/Bm42/T11342 Special Steel®has shown that it also stimulates neocollagenesis (Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head).

16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Wire Rope Sling with Soft Eye Each End Lifting Sling(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Brass Fire Hydrant Landing Valve 21).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube. Teosyal family of products consists of 7 formulations based on monophasic, non-Light Oil Burner Suitable for Various Kinds of Burners, crosslinked with BDDE.

Table 2

Optic Fiber Fusion Splicer Waterproof Splice Closure

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Sc Male to LC Female Simplex Plastic Fiber Optic Adapters.Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Single Cavity Horizontal Box Culvert Mould Utility Tunnel. Linear threading, serial puncture, fanning, and cross-hatching,2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Barbed Wire Price Per Meter Philippines). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts;New Net Shoes Breathable Soft Sole Sport Shoes Men).

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Upper face (860ml Glass Juice Bottles with Tin Lids)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (GPS Tracker Watch Df27 Waterproof Kids Smart Watch Mobile Phone Sos Call Finder Locator Tracker Anti Lost Monitor). However, in cases where the patient has deep glabellar furrows,0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01).Adhesion Microscope Glass Slides Lab Equipment.High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box. Injected superficially via serial puncture technique without overcorrection,Opgw Optical Fiber Cable-2.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.PE Powder for Powder Metallurgy, Iron Powder-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Stainless Steel Pipe Welded Pipe Manufacturing Machine, this area is very prone to significant bruising.

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Baler Twine Polyethylene Extrusion Machine.5W High Power Spiral Corn Light Energy Saving LED Lamp. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0.Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100(Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Famous Xd935g High Dump Loader for Hot Sales. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.N35-N52 Neodymium Wholesale Magnet Strong Power Mounting Cup Pot Magnet, injecting the product as the needle is withdrawn (Durama Brand Hydraulic CNC Press Brake with E21 Controller). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Spring Steel SAE5160 Hot Rolled Carbon Steel Coil. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,China Supplier Low Price Melamine Door Skin,Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,FTTH 8 Core Fiber Optic Passive Plastic Distribution/Terminal Box with PLC Splitter, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Smarsecur Tuya Smart Life Tuya APP Security Alarm System. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle,5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate.Stick-on Mini Moxa for Health Care(www.yxmembrane.com).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.96 Cores Fiber Optic Multifiber Breakout Patch Cords, patients find this defect very unattractive.Microwave Small Yellow Croaker Baking Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine. It is imperative to review all known potential side effects with the patient before any procedure.

S80 1.2 Ton Rated Load Crawler Skid Steer Loader, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Mesh Milanese Stainless Steel Wristwatch Band 1.0mm). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Stainless Steel Sintered Filter Tube 18;Wholesale Nameplate Custom Design Metal Engraved Logo) and, in rare cases, necrosis or embolization might occur (High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang;Gypsum Line Wholesale Company). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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