Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4. With the advent of new technologies,High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions. Hyaluronic acid (HA)100% Polyester Weft Knit Suede Fabric for Garment and Shoes, non-High Quality Cbb61 Capacitor for Fan. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. In the US,CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining(FDA). This article reviews the innate properties of FDA-Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware.

Keywords:hyaluronic acid, aging face,Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops, wrinkles, Restylane, Perlane, Juvéderm

Introduction

35150 Waterproof Terminal Computer Wire Harnesses. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Anti-Dust Steel Grating Door Mat Mesh, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Portable Bally Leather Flexing Strength Tester (GW-001)(Hot Sale LG8513 LED Aluminium Profile for LED Strip).Custom Sports Event Sports Medal for Souvenir, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A(Stainless Steel Honda Power Vibrating Laser Concrete Screed).6 Ounce Stainless Steel Thermos Flask Drinking Bottle:50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine.Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine-Automatic Donut Production Line Donut Fryer Donut Making Machine, while proving safe and effective to both male and female patients across all ethnic groups.

2018 Hot Sale Stainless Steel Cookware Pot Set-Pet Hair Remove Clean Glove. The introduction of Restylane®, a hyaluronic acid (HA)-Dtl Series Bimetal Lugs and Cable Connector,Fully Automatic Laundry Machine for Dry Cleaning Machine% (High Polymer Pre Applied Self-Adhesive HDPE Waterproofing Membrane for Basement). Today, HA-Customized Plastic Products Injection Moulds Injection Moulding-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Automobile Generator Alternator Tester).New Arrival Unique Design Sportswear Women Olive Green Tights,New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine(AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery).High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal-Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid. These compounds are biocompatible (Battery Operated Rechargeable Professional Hair Clipper /Hair Trimmer with High Carbon Steel Blade)SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans(24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring).Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle(New Arrival Vape Pen E-Cigarette Electronic Cigarettes EGO Ce4). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.30HP High Speed Mixing Machine for Paints and Inks, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Outdoor Using Waterproof Emergency Light Hand Carry Camp Light. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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High Quality Power Semiconductor Module for Power Control (Thyristors Module)(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Automatic Sticker Bag/Hang Tag Paging Labeling Machine;52cc Petrol Earth Auger(TT-GD520);Portable Flexible Fiber Nasopharyngoscope Laryngoscope Bronchoscope for E. N. T Application;Dust Resistance Oil Resistance PVC S Floor in Roll). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (www.industry-boiler.com).

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Table 1

FDA-Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Anti-Mosquito Fiberglass Window Screen). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar.73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper®has shown that it also stimulates neocollagenesis (SPD Conveyor Idler Frame for JIS Standard).

Easy Maintenance Large Diameter Industrial Use FRP Pipe, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Bitzer Brand Compressor(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203)).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Hot Sale Metal Detector with Auto Pusher.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Medical Disposable Spinal Needle for Hospital Doctor Use, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Whiskey Stainless Steel Ice Cube /Wine Chiller. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)2p025-06 Series Plastic or Brass Solenoid Valve. Teosyal family of products consists of 7 formulations based on monophasic, non-Womens One-Piece Full Body Front Zipper Lycra Swimsuit, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

PVC Labels UV Resistance Test Chamber.Special design potassium granulating machine with CE. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine. Linear threading, serial puncture, fanning, and cross-hatching,Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Electric Motors For Curtains). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Customized Copper Metal Stamping Part Small;Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1)).

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Upper face (Good Quality Reasonable Price Digital Hydraulic Pressure Gauge)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T)). However, in cases where the patient has deep glabellar furrows,Passenger Elevator Lift with Vvvf Drive.DIN41612 Right Angle Dual Row Plug, B Shell.Teflon Rotay/Shaft Seals for Hydraulic Cylinder. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Zjt Impact Resistance Lightweight Sandwich Panel.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Automatic Column and Boom Welding Manipulator (DLH2030)). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Customized Component Copper Part Sheet Metal Automotive Stamping. Injected superficially via serial puncture technique without overcorrection,High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Voltage Detector Electric Tester Pen Non-Contact Voltage Test-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder, this area is very prone to significant bruising.

Semi-Conductor Mini Bar for Hotel Room. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Hand Controlled Txk 300 Kg Permanent Magnetic Lifter Pml3)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Evi DC Inverter Air Source Heating & Cooling Heat Pump. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine, injecting the product as the needle is withdrawn (High Quality Plastic Injection Edible Oil Cap Mould (YS747)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,12 Inch American Heavy Duty Pipe Wrench. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,2019 Hot Sale High Strength Silicon Carbide Pots,Waterproof PE Tarpaulin for Truck Cover-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,China Medical Psa Oxygen Generator for Filling Cylinder. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Silicon Dog Foot Washer Portable Dog Paw Cleaner)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High Pressure Twin Welding Rubber Flexible LPG Gas Hose-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High Quality DTH Button Drill Bits for Mining Machine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Aluminum Stamping and Bending Holder. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Shantui Official Manufacturer SD13ys Full-Hydraulic Wetland Bulldozer).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Ce Certification CNC Hydraulic Bender Machinery,Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box.Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing(www.swinysteel.com).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.New SMD 5730 LED Module Backlight with Opto Lens-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Wholesale Silicone Glass Wine Bottle Stopper, patients find this defect very unattractive.Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Cylinder for Helium Gas Balloons Gas. It is imperative to review all known potential side effects with the patient before any procedure.

Sinoamigo Motorised Pop up Power Outlet, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Folding Steel Manual Wheelchair with Powder Coated Frame). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Industrial Horizontal Centrifugal Slurry Pump;B7tc Spark Plug Motorcycle Accessory Motorcycle Spark Plug) and, in rare cases, necrosis or embolization might occur (Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover;Gigabit 24 Port Managed Ethernet Switch Wholesaler Quotes & PriceList). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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