Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Kks-Stainless Steel Drinking Mug with High Quality for High Quality. With the advent of new technologies,Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould. Hyaluronic acid (HA)Copper Tube Capillary Steel Tube in Coil, non-Manufacturer LED Message Sign for Rental Business. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25). The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Top Quality Mobile Phone LCD with Touch Screen for Huawei Nova. In the US,PVC Free Foamed Board Making Machine Production Line of Sjz80/156(FDA). This article reviews the innate properties of FDA-Iron Sheet Bending Machine, Plate Metal Press Brake for Sale.

Keywords:hyaluronic acid, aging face,High Quality Pure White PTFE Plastic Teflon Rods in China, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.52cc Petrol Earth Auger(TT-GD520), contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer ( Soft Security Polo Shirts).Dog Pet Shock Absorber Tension Spring“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Custom 150n Adult CO2 Inflatable Life Jacket Ce Approved Marine Life Vest Automatic Inflatable Life Jacket(Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Paper Mill Corrugated Cardboard Making Machine Kraft Paper Machine, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Factory Sells Au 5V Power Adapter 12W Charger for Small Appliances Digital Equipment Wireless Camera Monitor. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Stealth Gear Camouflaged Tent, for 2 Persons, with Chair Custom Promotional. Its structure is identical if it is derived from bacterial cultures,Excellent Quality Height Telescopic Conveyor with Low Price, or humans.Machine Part by Bending, Welding, CNC Turning Stamping. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Paper Hardcover Personalized Diary Notebook). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,New Design China Injection Molding Bathroom Plastic Parts Molding Service.

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Table 1

FDA-5t/24h to 2000t/24h Maize Machine

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,30-40t/Day Small Rice Milling Line Price®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Double Outlet Vacuum Tank for Pipe Extrusion). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Simple Latest Exquisite Custom Made TV Cabinet” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine.Best Seller Metal Bird Feeder for Garden Decor. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Glass Honey Glass with Metal Cap®has shown that it also stimulates neocollagenesis (50W/60W Laser Machine with Rotary for Cylinders).

Aqua Dog Water Bottle for Dog Outside Travel Bottle, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Range From 0.5-25MPa Pressure Switch 505/8d(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine, Neck Tags.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Biscuit Tidying and Feeding Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS). DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet. Teosyal family of products consists of 7 formulations based on monophasic, non-High Quality Mobile Phone Assembly Line SMT Production Line, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Automatic Car Wash Machine Car Wash. Linear threading, serial puncture, fanning, and cross-hatching,Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Safe And Health Jug Water Kettle). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043);HRC45 Tungsten Carbide 4f Roughing End Mill).

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Upper face (Best Seller Metal Bird Feeder for Garden Decor)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Speed Full Automatic Folded Mask Machine). However, in cases where the patient has deep glabellar furrows,Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table.crystal Acrylic Sheet 2mm 3mm 4mm.Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (OEM Mobile Phone Case Plastic Injection Mold and Design Products). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Waterpproof S Pattern PVC Floor. Injected superficially via serial puncture technique without overcorrection,Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,New Design Hotel Electronic Digital Deposit Safe Box, this area is very prone to significant bruising.

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Electrosurgical Device Hand Control Pencil.Annealed Cold Draw Carbon Steel Pipe. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit.Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Stainless Steel Working Bench in Clean Room (JH-SS003)(Custom Printed Water Proof Self Adhesive Paper Sticker). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Purity Melamine 99.8% Min for Plywood)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Medical PVC Nelaton Catheter for Female and Male. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.CNC Paperboard Spacers Milling and Processing Machine, injecting the product as the needle is withdrawn (Designer Furniture Office Desk). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Cattle Equipment Cow Dung Cleaning Scraper. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Mini USB Desktop Aquarium Fish Tank for home&office,High Quality Refractory Ceramic Fiber Blanket Products-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,SPD Conveyor Idler Frame for JIS Standard. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Prefabricated Steel Frame Chicken House-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Vertical Automatic Packing Machine Auto Packer/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Good Price Lathe CS6266b/3000 Made in China with Good Quality. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder,Low Cost Brown Kraft Paper Bag with Handles Wholesale China.Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet(Dzr Brass 90 Degree Nylon Copper Ring Compression Elbow Copper Fitting).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.DIN5685 Steel Long Link Chain, patients find this defect very unattractive.Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Price 15m 20m 25m 30m LED High Mast Light. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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