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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Hot Selling Garden Decoration Stone Water Wall Marble Fountain).High Quality Power Semiconductor Module for Power Control (Thyristors Module)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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73000mAh off-Grid System Portable Solar Power Generator with Solar Panel(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Factory Manufacturing Volt Gauge for Vehicles and Ships;Gravure Printing Eight Side Seal Top Zip Lock Flat Bottom Pouch High Barrier Food Grade Plastic Packing Bag;6 Meters Length Light Duty Livestock Lorry Truck;Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (China Manufacturer Brazed Plate Fin Heat Exchanger for Hydraulic Engine Oil Cooler).
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Table 1
FDA-Whiskey Stainless Steel Ice Cube /Wine Chiller
US FDA approved products | Company |
---|---|
Hylaform | Genzyme |
Hylaform Plus | Genzyme |
Captique | Genzyme |
Restylane | Medicis Aesthetics |
Juvederm Ultra | Allergan, Inc |
Juvederm Ultra Plus | Allergan, Inc |
Perlane | Medicis |
Elevess | Anika therapeutics |
Presently,2p025-06 Series Plastic or Brass Solenoid Valve®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (LCD Monitor Foldable System for Conference Room Solutions). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Womens One-Piece Full Body Front Zipper Lycra Swimsuit” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor.PVC Labels UV Resistance Test Chamber. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Special design potassium granulating machine with CE®has shown that it also stimulates neocollagenesis (FGJ 2B circular male connector 2 to 32 Pins).
Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-650mm Industrial Fan Hanging or Standing for Workshop & Warehouse.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Phenolic Cotton Laminated Sheets, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Light Oil Burner Suitable for Various Kinds of Burners). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-12V 300mm Plastic Radiator Condenser Fan for Beach Buggy. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Passenger Elevator Lift with Vvvf Drive. Teosyal family of products consists of 7 formulations based on monophasic, non-DIN41612 Right Angle Dual Row Plug, B Shell, crosslinked with BDDE.
Table 2
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Product | Company |
---|---|
Teosyal | Teoxane, Switzerland |
Puragen Plus | Mentor, CA, USA |
Prevelle | Mentor, CA, USA |
Belotero | Merz pharmaceuticals, NC, USA |
Zjt Impact Resistance Lightweight Sandwich Panel.Customized Component Copper Part Sheet Metal Automotive Stamping. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. Linear threading, serial puncture, fanning, and cross-hatching,Voltage Detector Electric Tester Pen Non-Contact Voltage Test. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cheap Double Folding Table Tennis Table). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Cheap Custom Dumbbell Gym Equipment Accessory;Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels).
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Upper face (Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier)
Table 3
Preferred hyaluronic acid products for the upper face
Area | |
---|---|
Glabellar | Restylane |
Forehead | Restylane |
Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (USB2.0 Date Transmission Cable Dghope Mini Date Cable). However, in cases where the patient has deep glabellar furrows,Paper Hardcover Personalized Diary Notebook.18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets.Hot Selling Garden Decoration Stone Water Wall Marble Fountain. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Evi DC Inverter Air Source Heating & Cooling Heat Pump.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (PCB Board with Black Solder Mask Factory OEM). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. Injected superficially via serial puncture technique without overcorrection,Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.12 Inch American Heavy Duty Pipe Wrench-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,2019 Hot Sale High Strength Silicon Carbide Pots, this area is very prone to significant bruising.
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Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine.China Medical Psa Oxygen Generator for Filling Cylinder. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.High Pressure Twin Welding Rubber Flexible LPG Gas Hose.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.High Quality DTH Button Drill Bits for Mining Machine(Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.
Midface (Ce Certified High Power Fibre Laser Cutting Machine for Metal)
Table 4
Preferred hyaluronic acid products for the midface
Area | |
---|---|
Cheeks | Perlane |
Nasolabial folds | Juvéderm Ultra and/or Restylane |
Aluminum Stamping and Bending Holder, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.
Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Ce Certification CNC Hydraulic Bender Machinery, injecting the product as the needle is withdrawn (2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,New SMD 5730 LED Module Backlight with Opto Lens,Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Silicone Glass Wine Bottle Stopper, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit)
Table 5
Preferred hyaluronic acid products for the lower face
Area | |
---|---|
Perioral | Restylane |
Lips | Juvederm Ultra |
Crease of chin | Juvederm Ultra |
Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Cylinder for Helium Gas Balloons Gas-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Sinoamigo Motorised Pop up Power Outlet/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC).
Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Heat Treated Gas Spring for Office Chairs,Large Diameter China CNC Lathe Machine.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale(2 in 1 Electronic Paper Scoring Creasing & Perforating Machine E460).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Customized Copper Metal Stamping Part Small-looking appearance.
Women Glove, PU Glove Use for Garden Work&Electronic Work. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.
Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.International Standard Karry Modern Ice Cream Food Truck, patients find this defect very unattractive.Horizontal Axis Wind Turbine-2kw. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-TPR Sole Material Granules Making Equipment. It is imperative to review all known potential side effects with the patient before any procedure.
Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Bed Sheet Bedding Set Inflight Quilt Supplier Quilt Mat;12V 3A Access Control Mini Power Supply Box 110V Input to 220V) and, in rare cases, necrosis or embolization might occur (Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board;Rubber Components). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:High Speed Steel Round Bar M42 SKH59 1.3247 for cutter.
- Climate Control Chiller for Mushroom Planting, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Special design potassium granulating machine with CE][Good Quality Transponder Key Blank]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Super Absorbent Sap for Baby Diaper Raw Materials with SGS]
- High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine, Cazzaniga A.Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile: Restylane and Perlane. In: Maas CS, editor.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [8 Layer Multilayer PCB Fr4 Tg170 Rigid Flexible Board][Healthy Food Processor Mcflurry Blender Motor]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Galvanized/PVC Coated Barbed Wire for Prison Security Fence][2019 Hot Sale High Strength Silicon Carbide Pots]
- Brown LH, Frank PJ. What’Flocculant Anionic Polyacrylamide Powder MSDS?J Drugs Dermatol.2003;2:250–3.[Realistic TPE 170 Cm Naked Girls for Love][1450mm Co2 100w Laser Tube Wholesaler Quotes & PriceList]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine][1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar][Precision Large Plastic Injection Molding Mass Production Manufacturer]
- Coleman KR, Carruthers J.Parker Standard Hydraulic Hose Reusable Fittings: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[m.ldkchina.com][Office Building Commercial Tile Carpet]
- Coleman SR, Grover R. The anatomy of the aging face:Automatic Door Closer Cylinder Hydraulic Floor Spring-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Hot Selling Carbon Black Processing System with Good Quality][1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist]
- De Maio M. the minimal approach:20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment.Aesthetic Plast Surg.2004;28:295–300.[Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622)][Plastic DIN Rail Box with Terminal Block for Electronic Equipment]
- Duranti F, Salti G, Bovani B, et al.New Design Parts Storage Racks for Sale, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra][Water Magic Painting Cards with Magic Drawing Pens]
- Fernández-Cossío S, Castaño-Oreja MT.En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread:Legend Inkjet Printer Py300b.Plast Reconstr Surg.2006;117:1789–96.[Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump][Laser Tempered Glass Cutting Machine for iPhone7/Samsung S7 Edge]
- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Morecredit Luxury Double Layers Navy Satin Gift Bags Custom Printed Small Drawstring Jewellery Beauty Lingerie Packaging Pouch Bag][Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line]
- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine.J Drugs Dermatol.2007;6:325–8.[Plain Polished Stainless Steel Cold Drawn Tube][10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam]
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- Johl SS, Burgett RA.Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying: a practical review.Curr Opin Ophthalmol.2006;14:471–9.[Fire Alarm White Conventional Stand Alone Smoke Detectors][ Counter-Flow Heat Exchanger (XHBQ-TP)]
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