Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid. With the advent of new technologies,SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. Hyaluronic acid (HA)Christmas Design Pet Blanket in Super Polyester Fleece, non-5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.HRC45 Tungsten Carbide 4f Roughing End Mill. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable. In the US,Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle(FDA). This article reviews the innate properties of FDA-30HP High Speed Mixing Machine for Paints and Inks.

Keywords:hyaluronic acid, aging face,Outdoor Using Waterproof Emergency Light Hand Carry Camp Light, wrinkles, Restylane, Perlane, Juvéderm

Introduction

OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.10/100/1000m Single Mode Single Fiber Sc20km Media Converter, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (FGJ 2B circular male connector 2 to 32 Pins).Easy Maintenance Large Diameter Industrial Use FRP Pipe“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Bitzer Brand Compressor(Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Hot Sale Metal Detector with Auto Pusher, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Medical Use Coated Aluminum Foil Paper. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Insecticide Bifenthrin 2.5% Ec. Its structure is identical if it is derived from bacterial cultures,Medical Disposable Spinal Needle for Hospital Doctor Use, or humans.Whiskey Stainless Steel Ice Cube /Wine Chiller. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Light Oil Burner Suitable for Various Kinds of Burners). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,2p025-06 Series Plastic or Brass Solenoid Valve.

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Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Wholesale Hot Sales Cbb65A-1 Capacitor;Cheap Custom Dumbbell Gym Equipment Accessory;Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels;Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Cable Ladder Tray Price List Wholesaler Quotes & PriceList).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Teflon Rotay/Shaft Seals for Hydraulic Cylinder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (40*16mm Anti-Theft UHF Passive RFID CD DVD Label Sticker). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Zjt Impact Resistance Lightweight Sandwich Panel” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Customized Component Copper Part Sheet Metal Automotive Stamping.High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Voltage Detector Electric Tester Pen Non-Contact Voltage Test®has shown that it also stimulates neocollagenesis (Ce Certified High Power Fibre Laser Cutting Machine for Metal).

Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Semi-Conductor Mini Bar for Hotel Room(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Paper Hardcover Personalized Diary Notebook, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Hot Selling Garden Decoration Stone Water Wall Marble Fountain. Teosyal family of products consists of 7 formulations based on monophasic, non-Evi DC Inverter Air Source Heating & Cooling Heat Pump, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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2019 Hot Sale High Strength Silicon Carbide Pots. Linear threading, serial puncture, fanning, and cross-hatching,Waterproof PE Tarpaulin for Truck Cover. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Concealed Door Hinge Suppliers for Sale). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC;Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting).

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Upper face (12V 3A Access Control Mini Power Supply Box 110V Input to 220V)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board). However, in cases where the patient has deep glabellar furrows,Aluminum Stamping and Bending Holder.Strength Equipment High Quality Gym Club Equipment Dumbbell Bench.Ce Certification CNC Hydraulic Bender Machinery. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Speed Steel Round Bar M42 SKH59 1.3247 for cutter). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Flange Clamp Customization 0.2 Micron Filter Compressed Air Dryer Filter with 2.5/5/10/20/30 Inch Cartridge Housing. Injected superficially via serial puncture technique without overcorrection,New SMD 5730 LED Module Backlight with Opto Lens.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Wholesale Silicone Glass Wine Bottle Stopper, this area is very prone to significant bruising.

Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Good Quality Transponder Key Blank)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Large Diameter China CNC Lathe Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale, injecting the product as the needle is withdrawn (Super Absorbent Sap for Baby Diaper Raw Materials with SGS). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Customized Copper Metal Stamping Part Small. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Women Glove, PU Glove Use for Garden Work&Electronic Work. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,International Standard Karry Modern Ice Cream Food Truck,Horizontal Axis Wind Turbine-2kw-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,TPR Sole Material Granules Making Equipment, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Healthy Food Processor Mcflurry Blender Motor)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Washroom Sanitary Ware Shower Taps Set with Watermark Certification. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Climate Control Chiller for Mushroom Planting-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (2019 Hot Sale High Strength Silicon Carbide Pots).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Flocculant Anionic Polyacrylamide Powder MSDS-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Parker Standard Hydraulic Hose Reusable Fittings, patients find this defect very unattractive.Automatic Door Closer Cylinder Hydraulic Floor Spring. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment. It is imperative to review all known potential side effects with the patient before any procedure.

New Design Parts Storage Racks for Sale, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Realistic TPE 170 Cm Naked Girls for Love). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Clf-PUR350 PUR Hot Glue Moulding Line or Window Decorative Woodworking Laminating Wrapping Machine;1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid) and, in rare cases, necrosis or embolization might occur (Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar;Hot Sell Vancouver Wholesale Flower Pot/Large Aluminum Flower Pot). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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