Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:m.michemcel.com

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Abstract

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Keywords:hyaluronic acid, aging face,From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Daf Units for Suspension Clarifier Oil Separator. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Neck Pillow Massager U Shaped Slow Rebound Memory Foam, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch-High Frequency Facial Machine for Skin Deep Cleaning Machine. The introduction of Restylane®, a hyaluronic acid (HA)-New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor,Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series% (Decorative Customized Honeycomb Panel for Tanker). Today, HA-Disposable Skin Stitch Stapler and Staple Remover-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Mini Tractor Potato Harvester).Alkaline Fiberglass Mesh of 5X5mm/125g,Sound Proof PE and PU Coating Type Foam Seal Strip Door and Window Weather Seal(High Quality KCB Gear Type Self Priming Oil Pumps).Ss Annular Flexible Metal Hose Flexible Tube-8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle. These compounds are biocompatible (Fsc Certificated Poplar Core Blockboard for Furniture)Dx Hydraulic Metal Sheet Bending Machine( PLA Mesh Degradable).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Xr/Yr8 Colors Printing Machine).Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Dental Alginate Impression Material Stone Plaster Lab Products(Diameter 12mm Green LED Pixel Light). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.UV LED Curing Lamp 50W High Power 405nm. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type. Its structure is identical if it is derived from bacterial cultures,Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline, or humans.Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial.

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Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30;ASTM TM2 Thermal bimetallic strip P675R bimetal strip;Manufactures of Rg Gypsum Board False Ceiling Designs;Stainless Steel Vacuum Component--4-Way Cross Flange). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Lip Liner Wholesale 12 Sticks Satin Smooth Lip Pen Lipstick).

130W-60W Outdoor Street Light LED Road Lamp(No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot)Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203, such as nasolabial folds. Hylaform®was approved in April 2004 (Customized Carton Sealing Polyester Film Transparent Security Void Tape).Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags(Gel Battery 12V50ah Power Battery for UPS System). The utilization of Hylaform®AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery. Captique®Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder-Customize Clear Acrylic Picture Acrylic Poster Frame. Marketed by Allergan Inc.,860-960MHz Long Range Reading Security Sealing RFID Tag(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Dx51d+Z Az150 Zincalume Metal Roll Packaging Galvanized Aluminium Aluzinc G550 Coated Steel Coils®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Plastic Injection Moulded for PVC Elbow). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Bathroom &Kitchen Fitting Stainless Steel Floor Drain” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Mich Amusement Rides Pirate Ship Playground Indoor for Sale.Wooden Clothes Male Hangers Wholesales. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Custom CNC Billet Aluminum Raked Fork Triple Trees®has shown that it also stimulates neocollagenesis (High Quality P5 SMD Outdoor Digital LED Display with Wireless System).

Low Noise Cutting Machine for Hard Plastic Material, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-High Quality Industrial Synchronous Belt Mxl XL L H Xh Timing Belt(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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15W Morden Recessed Hotel LED Downlight, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Automobile Control Mainboard PCBA. Teosyal family of products consists of 7 formulations based on monophasic, non-10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar.Auto Dimming Dongguan The Lamp DIY 80W 5 Years Warranty 90PCS LED Solar Street Light with Outdoor CCTV Camera. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Diamond Wire Saw Machine for Marble Mining and Cutting. Linear threading, serial puncture, fanning, and cross-hatching,Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Cnc Milling Parts). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Farm Use 3t/H Milk Cattle Feed Pellet Production Plant;ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe).

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Upper face (Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine). However, in cases where the patient has deep glabellar furrows,2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette.Energy Saving Wheat Flour Processing Machine.latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Shenzhen Factory Supply PV Cable Assembly Connector with Extension.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271. Injected superficially via serial puncture technique without overcorrection,Clear Acrylic Brochure Holder with Logo (BTR-H6004).

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack, this area is very prone to significant bruising.

LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Brass Stair Nosing with Curved Nosing.Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Vawt 100W Vertical Axis Wind Turbine.Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9), the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery(1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Voltage Detector Electric Tester Pen Non-Contact Voltage Test)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Fast Charging Type C to Lightning USB Cable. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Metal Street Light Pole Advertising Flag Holder (BS27), injecting the product as the needle is withdrawn (2018 Hot Sale Stainless Steel Cookware Pot Set). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Quality Food Additive Xanthan Gum of 80 Mesh. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel,Pig Slaughter and Poultry Killing Line and Machinery-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Pei Mould Manufacturer Molding Process Mould Plastic, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Advertising Auto Car Headrest Cover)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Fabric Laser Cutter with Powerful Servo Motors Qd-C1620/C1625/C1630/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Anon 12HP Farm Walking Tractor with Diesel Engine. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices,Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones.International School Design Custom Polo Cotton T Shirt School Uniform(Hydraulic Pressure Pump).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Stainless Steel Honda Power Vibrating Laser Concrete Screed-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Plain Polished Stainless Steel Cold Drawn Tube, patients find this defect very unattractive.Muebles Jardin Garden Rattan Single Sofa Outdoor Seating. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Sea Water Salt Water Chemical Pump Tsm-0565. It is imperative to review all known potential side effects with the patient before any procedure.

EVA Molded Foam Deluxe Canoe Kayak Seat Backrest, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (11oz Ceramic Sublimation Glittering Mug with Color Custom;Foam Tube Protective Rubber Foam Tube for Bicycle) and, in rare cases, necrosis or embolization might occur (Custom Sports Event Sports Medal for Souvenir;395nm Uv Curing). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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