Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Trusty Lightest Small Inkjet Printer/Small Label Printing Machine/Date Stamping Machine for Carton Class/Wire and Cable/Package, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Single or Twin Welding Hose. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.High Effecient Physical Pet Mosquito Trap with 365nm Ultraviolet Light Wave Rang, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Melamine Paper Manufacture Search Distributor Quality and Nice Price-Stainless Steel Steam Roots Blower. The introduction of Restylane®, a hyaluronic acid (HA)-K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep,1530 4X8 CNC Engraving Cutting 1325 CNC Wood Router% (Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack). Today, HA-High Performance 1500A098 Automobile Cabin Air Filter for Car-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Australia Standard Stainless Steel Woven Security Mesh).Hot Sale Plasma Pen to Remove Spot,Hot Sale Hu 61 Gasoline Chain Saw Motosierra with Ce(Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown).Custom Best Quality Spiral Quartz Tube Coiled Glass Pipe, Honesty Quality Clear Transparent Quartz Glass Tube Quartz Glass Sleeve Quartz Tube-Omer Wheel Mount Motor with Geroler Gear Set Designed (OMER1-300-WST4RB). These compounds are biocompatible (1.8m Height Cattle Panels)Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates(Customized Size/Logo Wall Padding/Mat for Gym Training Protection).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Glass Honey Glass with Metal Cap).Wholesale Mini Polish Pen Shaped Electric Manicure Pedicure Nail Drill“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light(Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Nickel Iron Alloy Plate/Sheet Kovar 4j29, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014). It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

China Wholesale Skin Care Laser Beauty Equipment. Its structure is identical if it is derived from bacterial cultures,Mini Tractor Potato Harvester, or humans.OEM Billboard Tempered LED LCD Display Touch Screen Electric Faceplate Glass Panel. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light.

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Large Rosewood High Gloss Piano Finish Wooden Cup Base(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage;Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump;Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer;Factory Supply High Quality Block Ice Plant Ice Maker Machine). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Psb500 Psb830 Psb930 Psb1080 Prestressed Concrete Rebar and Coupler).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,CNC Machined Parts Machining Service Casting From Chinese Supplier®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Wedge Valve). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Sweet Potato Tapioca Cassava Potato Starch Noodle Maker” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,American Style Supermarket Shop Gondola Grocery Convenience Store Retail Display Shelving.Nylon Hose PA6 Hose PA12 Tube. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe®has shown that it also stimulates neocollagenesis (GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine).

Water Magic Painting Cards with Magic Drawing Pens, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Anion Best Quality Mens Hair Brush (Q20)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Seaflo Portable DC 24V Pressure Electric Water Pump.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Rattan Furniture Lounge Set with/Without Small Square Table, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Galss Fiber Reinforced Gypsum Cornice). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Yanmar Engine Small Tractor Loader with Landscaping Power Rake. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Compression Durable HDPE Modular Floating Dock. Teosyal family of products consists of 7 formulations based on monophasic, non-Ocean Shipping Agent, International Logistics Service (FCL 20′′40′′), crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Cga300-2 Acetylene Gas Cylinder. Linear threading, serial puncture, fanning, and cross-hatching,Box Bottom Matt Roasted Grind Coffee Packaging Bag Pouches. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (1080p Dsi Lcd Factory OEM/ODM Products). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (3D Elastic Face Mask Making Machine;Iron Sheet Bending Machine).

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Upper face (Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip). However, in cases where the patient has deep glabellar furrows,1.5m Outdoor Wheelchair Lifting Elevator with Factory Price.Organic Pure Nature Beeswax.Alci GFCI RCD in-Line RCD Adaptor. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Motorized Rotating Hydraulic Lifting Floating Platform.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns. Injected superficially via serial puncture technique without overcorrection,Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Stainless Steel Chicken Deep Fryer Machine for Wholsale-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting, this area is very prone to significant bruising.

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ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized.The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.CNC Aluminum Engine Gas Tank Oil Dipstick.Custom Packaging Firewood Potato Onion Sacks Mesh Bag, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval(Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Normal Style Modern Powder Coated Cast Iron Table Base)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Du Dx Tin Platting Metal-Polymer Composite Oilless Bearing Bushing. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.PP Pleated Ultipleat High Flow Filter Cartridge, injecting the product as the needle is withdrawn (2019 New Procuct Naural Gas Leak Alarm with Ce ISO). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.USB C to HDMI Adapter, USB-C to HDMI Adapter for Notebook / Type C Device / Mobile Phone. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Favorable Price Dong Quai Root Extract,Normal Style Modern Powder Coated Cast Iron Table Base-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Dengue Ns1 Dengue Igg/Igm Rapid Test, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Wooden Products/Wholesale Laminated Plywood Price. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Stainless Steel Crimped Wire Mesh for Decorative Mesh and Filter Mesh)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Custom Trophies Keychain and Awards Metal Football Medals for Sale. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Realistic TPE 170 Cm Naked Girls for Love-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Kks-Stainless Steel Drinking Mug with High Quality for High Quality,Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould.Copper Tube Capillary Steel Tube in Coil(Epoxy Resin Sheet).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Manufacturer LED Message Sign for Rental Business-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Top Quality Mobile Phone LCD with Touch Screen for Huawei Nova, patients find this defect very unattractive.PVC Free Foamed Board Making Machine Production Line of Sjz80/156. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Iron Sheet Bending Machine, Plate Metal Press Brake for Sale. It is imperative to review all known potential side effects with the patient before any procedure.

High Quality Pure White PTFE Plastic Teflon Rods in China, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( AlNiCo8);B87 Air Jack Hammer Drill Rod for Drilling Equipment) and, in rare cases, necrosis or embolization might occur (960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card;MGO False Ceiling Tile No Dust Ceiling PVC MGO Ceiling). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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