Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth. With the advent of new technologies,Flocculant Anionic Polyacrylamide Powder MSDS. Hyaluronic acid (HA)OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts, non-Parker Standard Hydraulic Hose Reusable Fittings. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Automatic Door Closer Cylinder Hydraulic Floor Spring. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment. In the US,New Design Parts Storage Racks for Sale(FDA). This article reviews the innate properties of FDA-En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread.

Keywords:hyaluronic acid, aging face,Legend Inkjet Printer Py300b, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.6063 Powder Coated White Aluminium Extrusion U Shaped Profile, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (48L Ce/RoHS Beverage Cooler for Home).Heavy Duty Liquid Nail Adhesive for Aluminum & Glass“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Permanent IPL System Hair Removal. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Galvanized Wire). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating.Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01®has shown that it also stimulates neocollagenesis (Road Painting Removal Shot Blasting Machine Manufacturer).

Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Green Color PVC Coated Razor Barbed Wire).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Daf Units for Suspension Clarifier Oil Separator.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Steel Wire Electro Galvanizing Machine with Ce Certified, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (High Quality Food Additive Xanthan Gum of 80 Mesh). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Industrial Hydraulic Oil Cooler. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)7.4V, 2600mAh Lithium Polymer Battery Pack for Heated Glove, Heated Shoes, Heated Insole, Heated Products (EH2600). Teosyal family of products consists of 7 formulations based on monophasic, non-Galss Fiber Reinforced Gypsum Cornice, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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High Frequency Facial Machine for Skin Deep Cleaning Machine. Linear threading, serial puncture, fanning, and cross-hatching,New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Carbon Steel U Bolt Clamp). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (96 Cores Fiber Optic Multifiber Breakout Patch Cords;Men′s  Workwear Winter Softshell Jacket Safety Clothing).

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Upper face (Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Best Quality Alu Tube Filling and Sealing Machine). However, in cases where the patient has deep glabellar furrows,8ml Empty Hanging Car Perfume Bottle Rope Wooden Cover Car Perfume Bottle.Dx Hydraulic Metal Sheet Bending Machine.High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Waterproof IP56 Metal/Steel Power Supply Distribution Board/Switchboard Cabinet.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Bulk Stock Armored Fiber Optic Cable for Outdoor Application. Injected superficially via serial puncture technique without overcorrection,Die Casting Aluminum Die Casting Mould LED Explosion Proof Lighting Fixture.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Dental Alginate Impression Material Stone Plaster Lab Products-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,3V-12V 30-36V 10W 20W 30W 50W 100W COB LED Chip, this area is very prone to significant bruising.

UV LED Curing Lamp 50W High Power 405nm. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale, injecting the product as the needle is withdrawn (China Factory Perfume Bottle of Competitive Price). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,130W-60W Outdoor Street Light LED Road Lamp. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Road Roller 20ton Tyre Roller (Front 4/Rear 5) XP203,Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Honeycomb Active Carbon for Removal of Benzene Air Cleaning)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Customize Clear Acrylic Picture Acrylic Poster Frame-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.860-960MHz Long Range Reading Security Sealing RFID Tag/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Folding Clear Plastic Party Birthday Candy Gifts Box Decorations Supplies Df527. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Mich Amusement Rides Pirate Ship Playground Indoor for Sale,Wooden Clothes Male Hangers Wholesales.Custom CNC Billet Aluminum Raked Fork Triple Trees(High Quality Outdoor Gazebo).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Low Noise Cutting Machine for Hard Plastic Material-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel, patients find this defect very unattractive.ASTM A653 Galvanized Steel Sheet/Prepainted / Galvanized Steel Coil /Sheet for Roofing. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine. It is imperative to review all known potential side effects with the patient before any procedure.

15W Morden Recessed Hotel LED Downlight, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Kids Big Creative Indoor Playground with Ball Pool and Slides). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Wholesale New DIY Building Multi Functional Vape Tool Kit;140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui)) and, in rare cases, necrosis or embolization might occur ( Platform;China Hose For Welding). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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