Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Weighing Booth for Cleam Room. With the advent of new technologies,Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket. Hyaluronic acid (HA)Disposable Baby Bib Manufacturer Home and Dental Use, non-45g Carbonless paper/Carbonless paper coating machine paper. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Carved Plastic Flower Pot (KD9901-KD9905). The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base. In the US,Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated(FDA). This article reviews the innate properties of FDA-Corrugated Paperboard / Cardboard Bursting Strength Tester.

Keywords:hyaluronic acid, aging face,Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Epoxy Resin for Powder Coatings).Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Stainless Steel Inox 904L 2205 1.4462 201 Tube

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Gge-Dd 1310nm 10mw +10mw Fiber Optic Led Transmitter). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder.Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump®has shown that it also stimulates neocollagenesis (2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum).

Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Max Rebar Tying Stainless Wire for Max Construction Tools(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Falling Film Water Chiller for Poultry Processing and Chicken Preserve).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-LED Panel Light 9W 3000K Square Shape IC Driver for Indoors.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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304 Stainless Steel Bag Filter Housings, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting. Teosyal family of products consists of 7 formulations based on monophasic, non-CE Certification Real 1: 1 Full Silicone Japan Sex Doll, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Fe3o4 Pigment Black Iron Oxide for Roof Tiles. Linear threading, serial puncture, fanning, and cross-hatching,Excellent Quality Diamond Silent Saw Blade for Sandstone. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (China Factory Computer Controlled Automatic Upholstery Fabric Textile CNC Round Knife Cutting Machine in Cloth Cutting). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (High Quality Mobile Phone Assembly Line SMT Production Line;Cheap and High Quality Flour Mill Price Pingle Complete Set Wheat Flour Mill Factory).

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Upper face (LF Passive TK4100 RFID Laundry Tag for Work Cloth)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (PVC Labels UV Resistance Test Chamber). However, in cases where the patient has deep glabellar furrows,China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price.Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump.Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Farm Machinery Tractor Pto Driven Hay Rake for Sale). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023). Injected superficially via serial puncture technique without overcorrection,Precision Large Plastic Injection Molding Mass Production Manufacturer.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Japan NTN 6316 Radial Deep Groove Ball Bearing Price List-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,ASME B16.34 A216 Wcb Butt Welded Globe Valve, this area is very prone to significant bruising.

High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Colorful Flocking Powder on Nail)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Laminated Insulating Tempered Safety Float Sandwich Railing Glass. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.2-Way Brass Electric Valve Ball AC220V Dn25 1, injecting the product as the needle is withdrawn (High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Mesh Milanese Stainless Steel Wristwatch Band 1.0mm. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,15*30mm Plastic Drag Carrier Chain for 3D Printer. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts,480V to 400V Step Down 3 Phase Transformer-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Grey Cute Plush High Quality Cat Soft Stuffed CE Toy. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Mens Women Custom Gym Bag with Shoe Compartment)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Electrical Power Fine Stone Concrete Pump with High Efficiency-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Hot Selling Carbon Black Processing System with Good Quality/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.2019 Hot Sell Normal Plastic Beverage Cap Mould,Natural Way to Clean Vegetables.Insect Netting Plastic Window Screen(fashion Design Scented Ceramic Candle for Party).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent-looking appearance.

Steel Spiral Idlers/Belt Conveyor Roller. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat, patients find this defect very unattractive.Dust Resistance Oil Resistance PVC S Floor in Roll. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round. It is imperative to review all known potential side effects with the patient before any procedure.

Cubic Zirconia 925 Silver Freshwater Pearl Pendant Necklaces, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist;12V 300mm Plastic Radiator Condenser Fan for Beach Buggy) and, in rare cases, necrosis or embolization might occur (Aluminum Handrail;2018 China New Design Fog Lamp Cover Rh -). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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