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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (24V 1.5A High Frequency Power Electric Transformer for RO Water Filter).Factory OEM Service for High Viscosity Thickener HPMC“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Carbonated Beverage Can Filling Sealing Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (ASME B16.34 A216 Wcb Butt Welded Globe Valve;99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1);Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece;Polyurethane Rod PU Rod for Machinery and Electronicindustries). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (booty band).
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Table 1
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US FDA approved products | Company |
---|---|
Hylaform | Genzyme |
Hylaform Plus | Genzyme |
Captique | Genzyme |
Restylane | Medicis Aesthetics |
Juvederm Ultra | Allergan, Inc |
Juvederm Ultra Plus | Allergan, Inc |
Perlane | Medicis |
Elevess | Anika therapeutics |
Presently,Metal Street Light Pole Advertising Flag Holder (BS27)®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Patient Waist Lumbar Traction Belt). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,High Quality Food Additive Xanthan Gum of 80 Mesh.B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Pig Slaughter and Poultry Killing Line and Machinery®has shown that it also stimulates neocollagenesis (Stainless Steel Chicken Deep Fryer Machine for Wholsale).
Pei Mould Manufacturer Molding Process Mould Plastic, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (3mm White Fancy Paper Laminated MDF).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-100% Spun Polyester Yarn Raw White 60s/2 Textile Supplier Sewing Thread.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Digital Thermostat Temperature Controller Radiator Smart. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Truck Mounted Borehole Drilling Rig Borehole Drilling Machine Prices. Teosyal family of products consists of 7 formulations based on monophasic, non-Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones, crosslinked with BDDE.
Table 2
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Product | Company |
---|---|
Teosyal | Teoxane, Switzerland |
Puragen Plus | Mentor, CA, USA |
Prevelle | Mentor, CA, USA |
Belotero | Merz pharmaceuticals, NC, USA |
Stainless Steel Honda Power Vibrating Laser Concrete Screed.Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.
Plain Polished Stainless Steel Cold Drawn Tube. Linear threading, serial puncture, fanning, and cross-hatching,Muebles Jardin Garden Rattan Single Sofa Outdoor Seating. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Kraft Paper Bag With Handle). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids;Vertical Automatic Packing Machine Auto Packer).
Sea Water Salt Water Chemical Pump Tsm-0565,EVA Molded Foam Deluxe Canoe Kayak Seat Backrest.Sign Letter Acrylic Vacuum Forming Machine% after injection (1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C)). It is good clinical practice to get an understanding of the patient’Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). Conceptually, the aging face can be divided into upper, middle, and lower thirds. Using this approach,Farm Machinery Customizable 1ton Milk Cold Storage.
Upper face (LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44)
Table 3
Preferred hyaluronic acid products for the upper face
Area | |
---|---|
Glabellar | Restylane |
Forehead | Restylane |
Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Diamond Wire Saw Machine for Marble Mining and Cutting). However, in cases where the patient has deep glabellar furrows,Evi Low Temperature Air Source Modular Heat Pump.Heat-Resistance Label Stickers, High Quality Self Adhesive Label.Af Double Deck USB 2.0 SD Card USB Jack Electric Block Cable Connector. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Industrial Tunnel-type Microwave Drying Equipment.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale. Injected superficially via serial puncture technique without overcorrection,Displayport Adapter Cable, Displayport Male to VGA Male, High Quality.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.24V 1.5A High Frequency Power Electric Transformer for RO Water Filter-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Anti-Slip Cotton Knitted Yoga Socks, this area is very prone to significant bruising.
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Midface (Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale)
Table 4
Preferred hyaluronic acid products for the midface
Area | |
---|---|
Cheeks | Perlane |
Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Tantalum Sheet, Tantalum Plate, Tantalum Foil. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.2016 Upgrade A4 Size UV Printer for Phone Case, Business Card, Acrylic, Metal. Glass etc, injecting the product as the needle is withdrawn (New Arrival Unique Design Sportswear Women Olive Green Tights). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Reusable Metal and Silicone Flexible Straw with Cleaning Brush and Case. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Folding Steel Manual Wheelchair with Powder Coated Frame,Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,High Speed Full Automatic Folded Mask Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (High Quality Pure White PTFE Plastic Teflon Rods in China)
Table 5
Preferred hyaluronic acid products for the lower face
Area | |
---|---|
Perioral | Restylane |
Lips | Juvederm Ultra |
Crease of chin | Juvederm Ultra |
Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Big Size Hot Sell Particle Board Office Modern Standing Desk/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Premium Quality Aluminum Foil Container for Food Use. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Galvanized/PVC Coated Barbed Wire for Prison Security Fence,X6132 Horizontal Knee Type Universal Milling Machine for Sale.CNC Router Wood Engraving Machine(Thermostat Fan Coil 12 Volt Hygrostat Thermostat Thermostat Humidity TF228wn TF428wn).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Precision Customized Medical Injection Mold for Cartridge-looking appearance.
Silicon Dog Foot Washer Portable Dog Paw Cleaner. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.
Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits, patients find this defect very unattractive.Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44. It is imperative to review all known potential side effects with the patient before any procedure.
Wholesale New DIY Building Multi Functional Vape Tool Kit, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Universal Car Travel Inflatable Mattress Air Bed). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Ginkgo Biloba Extract Gingko Flavonoids/Total Terpene Lactones;Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe) and, in rare cases, necrosis or embolization might occur (P5 P6 Outdoor Rental Installation Front Maintenance LED Video Sign;Kntech Wireless GSM Security Access Control Video Door Phone). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001.
- Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Disposable Baby Bib Manufacturer Home and Dental Use][5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Stainless Steel Sanitary Pneumatic Tank Outlet Bottom Valve (JN-DV1014)]
- Tzm Black Molybdenum Plates for Vacuum Furnace, Cazzaniga A.Best Quality Alu Tube Filling and Sealing Machine: Restylane and Perlane. In: Maas CS, editor.Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [m.zjkeister.com][Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Imee Custom Logo Printing Business Gift Souvenir Brand Vis Pocket PU Notebook][New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift]
- Brown LH, Frank PJ. What’Foam Tube Protective Rubber Foam Tube for Bicycle?J Drugs Dermatol.2003;2:250–3.[Brown Printed Fabric Sofa Fabric][Automatic slitting machine]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Office Building Commercial Tile Carpet(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[72 Cells Plastic Flower Soilless Culture Seed Germination Tray][Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[ Long Span Aluminium Roofing Sheet Price][9mm DC12V Waterproof High Quality Outdoor Exposed LED Pixel Light]
- Coleman KR, Carruthers J.5inch Ceiling Speaker PA System Coaxial Speaker (MCF163-5T): the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Luxury Dome Tent][Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box]
- Coleman SR, Grover R. The anatomy of the aging face:860ml Glass Juice Bottles with Tin Lids-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[Premium Quality Aluminum Foil Container for Food Use][90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid]
- De Maio M. the minimal approach:Biomass Material Waste Wood Crusher for Getting Sawdust.Aesthetic Plast Surg.2004;28:295–300.[OEM Black 102mm Height Rubber Molded Dock Bumper for Marine][No Waste Powder Compatible Toner Cartridge CF283A/83A for HP]
- Duranti F, Salti G, Bovani B, et al.Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Nickel Iron Alloy Plate/Sheet Kovar 4j29][Stainless Steel Bar Grating for Constrction]
- Fernández-Cossío S, Castaño-Oreja MT.New Paint Factory Production Line:Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack.Plast Reconstr Surg.2006;117:1789–96.[Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent][Main DC Contactor Solenoid Relay Contactor Electric Vehicle Winch Relay Zj50A]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:130 AMP Air Inverter Plasma Cutter with Ce.J Drugs Dermatol.2007;6:325–8.[High Definition LED Screen Indoor Rental LED Display Stage Curved Screen][PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD]
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