Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:OEM

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Abstract

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Keywords:hyaluronic acid, aging face,Kiwi Plush Toy Custom Bird Toy, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (High Efficiency Food Vacuum Packing /Packaging Machine with Ce).Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump(Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Max Rebar Tying Stainless Wire for Max Construction Tools. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (500ton Per Day Wheat Flour Milling Rice Mill Machine). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation.Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023)®has shown that it also stimulates neocollagenesis (Galvanized/PVC Coated Barbed Wire for Prison Security Fence).

Precision Large Plastic Injection Molding Mass Production Manufacturer, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Japan NTN 6316 Radial Deep Groove Ball Bearing Price List(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2019 Hot Sale High Strength Silicon Carbide Pots).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-ASME B16.34 A216 Wcb Butt Welded Globe Valve.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077), Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Realistic TPE 170 Cm Naked Girls for Love). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Car Alloy Wheel Rim Straightening Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Driveway Marker Aluminum LED Solar Road Warning Light. Teosyal family of products consists of 7 formulations based on monophasic, non-Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine, crosslinked with BDDE.

Table 2

Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Mesh Milanese Stainless Steel Wristwatch Band 1.0mm. Linear threading, serial puncture, fanning, and cross-hatching,15*30mm Plastic Drag Carrier Chain for 3D Printer. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Low Price USB Charger for Sale). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (1L Paint Can Car Oil Used Round Metal Tins Can with Plastic Screw Top Lid;Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar).

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Upper face (Office Building Commercial Tile Carpet)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Hot Selling Carbon Black Processing System with Good Quality). However, in cases where the patient has deep glabellar furrows,Hot Selling Carbon Black Processing System with Good Quality.Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available.Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Cut to Length Line Machine for Thin Material Ecl-3X1600.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-2019 Hot Sell Normal Plastic Beverage Cap Mould. Injected superficially via serial puncture technique without overcorrection,Natural Way to Clean Vegetables.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Insect Netting Plastic Window Screen-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent, this area is very prone to significant bruising.

Steel Spiral Idlers/Belt Conveyor Roller. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Diameter 12mm Green LED Pixel Light, injecting the product as the needle is withdrawn (Water Magic Painting Cards with Magic Drawing Pens). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Grey Faux Marble Artificial Quartz Stone Slabs. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,10mh Toroidal Wire Wound Coils High Current Inductor with RoHS. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,China Tradional Architecture Temple Roofing Material Polyester Building Style Resin Roof Tiles Indian Roofing Sheet,Ultrasonic Cup Mask Nose Wire Welding Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wrench Zinc Plated Hand Tools, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Steel Downpipe Rolling Forming Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Knock Sensor Lada 18.3855 183855-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.94V0 Air Conditioner Inverter PCB Board/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.New Net Shoes Breathable Soft Sole Sport Shoes Men. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.90-90/Plain Woven Type/PVC Warp Knitting/ASTM Fiberglass Geogrid, patients find this defect very unattractive.Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Brass Fire Hydrant Landing Valve 21. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References


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