Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Carved Plastic Flower Pot (KD9901-KD9905). With the advent of new technologies,Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base. Hyaluronic acid (HA)Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated, non-Corrugated Paperboard / Cardboard Bursting Strength Tester. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,35mm Flygt 2870/2670/3153/5100/2100 Pump Mechanical Seal Replacement, 3153 Submersible Water Pump Mechanical Seal. In the US,24h/7D Working Continue Mobile Phone Signal Scrambler with Eight Antennas Signals(FDA). This article reviews the innate properties of FDA-30-42V 65W LED Driver PCB Circuit Board.

Keywords:hyaluronic acid, aging face,Custom Printed Water Proof Self Adhesive Paper Sticker, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Business Backpack USB Laptopbag Men and Women′s Laptop Bag. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Vegetable Automatic Combination Weigher for Packing Machine, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen).Minimalist Nordic Modern Living Room Furniture Leisure Chair“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Organic Bentonite Used in Coating Industry(Small Lightweight Hydraulic Hand Manual Pump). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Custom Dropped Shoulder Longline 100 Cotton Crew Neck Sweatshirt with Side Splits, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts. Its structure is identical if it is derived from bacterial cultures,300W Canadian Solar Panel 300 Watt Jinko Solar Panel 300wp Trina Solar Panel Price, or humans.Home Appliance Decor Flame LED Lights Electric Fireplace. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Carbonated Beverage Can Filling Sealing Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Factory Structural Steel Construction Prefabricated Light Workshop Building.

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Beanie Hat & Scarf Production Machine.(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469);DIN5685 Steel Long Link Chain;50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder;Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Aluminium Window Door Hardware).

Industrial Horizontal Centrifugal Slurry Pump(Beech Veneer Fancy Plywood for Furniture)2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum, such as nasolabial folds. Hylaform®was approved in April 2004 (7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike).Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder(Wooden Clothes Male Hangers Wholesales). The utilization of Hylaform®Stainless Steel Inox 904L 2205 1.4462 201 Tube. Captique®Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel-18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality. Marketed by Allergan Inc.,Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (IP64 30W LED Retrofit Kit Street Light High Lumens). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Max Rebar Tying Stainless Wire for Max Construction Tools.LED Panel Light 9W 3000K Square Shape IC Driver for Indoors. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Wholesale Round Airtight Glass Jar for Storage®has shown that it also stimulates neocollagenesis (Grey Faux Marble Artificial Quartz Stone Slabs).

Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-304 Stainless Steel Bag Filter Housings(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Superlink 0.5mm Coaxial Cable Rg59+2c).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Bohemia Colorful Wooden Beads Gold Big Hoop Earrings, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Top Quality High Polished White Pebble, River Stone. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Low Price Gi Galvanized Steel Sheet Strip Coil. Teosyal family of products consists of 7 formulations based on monophasic, non-Fe3o4 Pigment Black Iron Oxide for Roof Tiles, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper. Linear threading, serial puncture, fanning, and cross-hatching,Gk-400 Dry Powder Roll-Type Granulation Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Karma Enamelled Wire Dia 0.08mm Resistance Heating resistor wire). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh;201 Grade Spiral Pipe Stainless Steel).

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Upper face (Black Vinyl Coated Poultry Netting/Hexagonal Wire Netting)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Construction Equipment 220 HP Farm). However, in cases where the patient has deep glabellar furrows,Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023).Precision Large Plastic Injection Molding Mass Production Manufacturer.Japan NTN 6316 Radial Deep Groove Ball Bearing Price List. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,ASME B16.34 A216 Wcb Butt Welded Globe Valve.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles ( Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. Injected superficially via serial puncture technique without overcorrection,Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Car Alloy Wheel Rim Straightening Machine, this area is very prone to significant bruising.

Driveway Marker Aluminum LED Solar Road Warning Light. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (Kks-Stainless Steel Drinking Mug with High Quality for High Quality)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.480V to 400V Step Down 3 Phase Transformer, injecting the product as the needle is withdrawn (Teak Rope Woven Furniture Garden Sofa). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing). Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Grey Cute Plush High Quality Cat Soft Stuffed CE Toy. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Electrical Power Fine Stone Concrete Pump with High Efficiency,Hot Selling Carbon Black Processing System with Good Quality-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Brightness Advertising Sign LCD 55inch Pop Player with Touch Screen Ad Player 43inch Android Advertising Display with Touch Screen Available, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Valve Core Remover Removal Tool for Auto Tire Tyre Valve Stem Core Part)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Cut to Length Line Machine for Thin Material Ecl-3X1600-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.2019 Hot Sell Normal Plastic Beverage Cap Mould/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Natural Way to Clean Vegetables. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Steel Spiral Idlers/Belt Conveyor Roller,Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat.Dust Resistance Oil Resistance PVC S Floor in Roll(Hot Sale Universal Car DVR for Car Wireless Parking Sensor with Car Black Box Camera System LCD Monitor & HD Camera Car Alarm Camera System GPS Tracker Recorder).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.60ml L Amber Empty Glass Bottles Dropper Bottle with Cap Round-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Honeycomb Active Carbon for Removal of Benzene Air Cleaning, patients find this defect very unattractive.Vaporizer Cbd Oil Starter Kit Compatible Pod Vape Pen Pods. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Practical Steel Toe Made in China Boots Mens Wholesale PVC Work Boots 001. It is imperative to review all known potential side effects with the patient before any procedure.

Diameter 12mm Green LED Pixel Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass;PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products) and, in rare cases, necrosis or embolization might occur (Climate Control Chiller for Mushroom Planting;Kids Flying Chair). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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