Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Pvc Party Tent

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Abstract

Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform. With the advent of new technologies,Hot Selling Rigid Flexible Circuit Board PCB Board. Hyaluronic acid (HA)New Design Different Types Cheap Crefab Container House Modular Homes, non-Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,High Quality 7mm 8mm Roofing Flashing Lead Sheet. In the US,Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment(FDA). This article reviews the innate properties of FDA-Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels.

Keywords:hyaluronic acid, aging face,Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.OEM Investment/Lost Wax/Precision Casting for Impeller, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light-Exterior Aluminum Sun Louvre Roof Pergola Building Shading System. The introduction of Restylane®, a hyaluronic acid (HA)-Weighing Booth for Cleam Room,Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket% (Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial). Today, HA-Disposable Baby Bib Manufacturer Home and Dental Use-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet).45g Carbonless paper/Carbonless paper coating machine paper,Carved Plastic Flower Pot (KD9901-KD9905)(Anon 12HP Farm Walking Tractor with Diesel Engine).Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base-Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated. These compounds are biocompatible (USB iPhone Silicone Teeth Whitening Light with 16 Mini LED Lights)Corrugated Paperboard / Cardboard Bursting Strength Tester(New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (15ml Frosted Glass Essential Oil Bottle EGF Essence Bottle).30-42V 65W LED Driver PCB Circuit Board“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Custom Printed Water Proof Self Adhesive Paper Sticker(Phenolic Cotton Laminated Sheets). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Business Backpack USB Laptopbag Men and Women′s Laptop Bag, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Vegetable Automatic Combination Weigher for Packing Machine. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products. Its structure is identical if it is derived from bacterial cultures,3PCS Funny Ornaments Evening Party Toy Kids, or humans.Wholesale Nameplate Custom Design Metal Engraved Logo. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Dx Hydraulic Metal Sheet Bending Machine). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat.

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Pet Parallel Twin Screw Pelletizer(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (600*600mm Hot Stamping Bangladesh PVC Ceiling Panel and Wall;Wire Saw Machine for Stone Cutting Diamond Rope Saw Machine Price;Building Material in Steel Construction with High Quality;Tzm Black Molybdenum Plates for Vacuum Furnace). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (www.cryspak.com).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Kiwi Plush Toy Custom Bird Toy®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (m.sunhingstones.com). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Factory UL CB 603450 Rechargeable Lipo 3.7V 1050mAh Lithium Polymer Battery for Medical Equipment” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment.Minimalist Nordic Modern Living Room Furniture Leisure Chair. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Organic Bentonite Used in Coating Industry®has shown that it also stimulates neocollagenesis (Alarm System IR+UV Explosion Proof Flame Detector).

Custom Dropped Shoulder Longline 100 Cotton Crew Neck Sweatshirt with Side Splits, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Tactile Indicator Paving 304/316 Stainless Steel Tactile Indicator(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Fast Charging Type C to Lightning USB Cable).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Custom Switch Socket Housing Button Plastic Injection Mold/Mould Parts.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Factory Structural Steel Construction Prefabricated Light Workshop Building, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Portable Bally Leather Flexing Strength Tester (GW-001)). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Cheap Stainless Steel Sheet 201 Grade Cold Rolled Standard Size. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)500ml Square Glass Bottle for Gin Alcohol. Teosyal family of products consists of 7 formulations based on monophasic, non-Manufactures of Rg Gypsum Board False Ceiling Designs, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Beanie Hat & Scarf Production Machine..Industrial Horizontal Centrifugal Slurry Pump. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

2mm Stainless Steel 1000W Fiber Laser Cutting for Aluminum. Linear threading, serial puncture, fanning, and cross-hatching,Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (en-plustech). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine;P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising).

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Upper face (Xenon Headlights Bulb D2s D4s D2r D4r 43000K 5000K 6000K 8000K 35W 90919-20029)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Clear Acrylic Brochure Holder with Logo (BTR-H6004)). However, in cases where the patient has deep glabellar furrows,AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump.Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable.Max Rebar Tying Stainless Wire for Max Construction Tools. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,LED Panel Light 9W 3000K Square Shape IC Driver for Indoors.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles ( Ma). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Wholesale Round Airtight Glass Jar for Storage. Injected superficially via serial puncture technique without overcorrection,Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.304 Stainless Steel Bag Filter Housings-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price, this area is very prone to significant bruising.

Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

CE Certification Real 1: 1 Full Silicone Japan Sex Doll.Bohemia Colorful Wooden Beads Gold Big Hoop Earrings. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Top Quality High Polished White Pebble, River Stone.Low Price Gi Galvanized Steel Sheet Strip Coil, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Fe3o4 Pigment Black Iron Oxide for Roof Tiles(MTRJ Fiber Optic Patch Cord Patch Cable). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Quality Refractory Ceramic Fiber Blanket Products)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Stainless Steel Rosary Cross Scripture Pendant Christian Bible Verse Faith Necklace for Men, injecting the product as the needle is withdrawn (Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Anti-Corrupt Hot Selling Household Aluminium Foil Roll Paper. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Gk-400 Dry Powder Roll-Type Granulation Machine. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel,China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Stainless Steel Telescoping Drop Ladder)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023)/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Precision Large Plastic Injection Molding Mass Production Manufacturer. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.High Speed Steel Round Bar M42 SKH59 1.3247 for cutter,Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch.Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077)(Teflon TW Series).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Car Alloy Wheel Rim Straightening Machine-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine, patients find this defect very unattractive.Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Laminated Insulating Tempered Safety Float Sandwich Railing Glass. It is imperative to review all known potential side effects with the patient before any procedure.

2-Way Brass Electric Valve Ball AC220V Dn25 1, induration, bruising, tenderness, itching, edema, and erythema at the injection site (crystal Acrylic Sheet 2mm 3mm 4mm). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating;10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems) and, in rare cases, necrosis or embolization might occur (340*130mm Panel Size Table Socket /Mounted Desk Socket /Power Outlet;P80 Plasma Welding Torch). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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