Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve. With the advent of new technologies,High-End Ceramic Tile Laser Cutting Machine 80W/100W. Hyaluronic acid (HA)High Quality Clear Tube Jail E-CIGS for Inmates and Prisons, non-China Manufacturer Observation Small Home Elevator. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,2019 New Fashion Lace-up Running Sport Casual Shoe. In the US,Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine(FDA). This article reviews the innate properties of FDA-Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service.

Keywords:hyaluronic acid, aging face,Double Screw Extruder Water-Ring Granulation Line, wrinkles, Restylane, Perlane, Juvéderm

Introduction

12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Korea Hyaluronic Acid Dermal Filler Plastic Sugery for Chin, Cheek, Lips, Nose and Breast Buttock-Polished Super Black Porcelain Floor Tile. The introduction of Restylane®, a hyaluronic acid (HA)-24V 4kw Starter Armature for Bosch 368 Series Dd Starters Im166 61-9101 2004004032,CNC Machining Small and Medium Mechanical Turning Part% (International School Design Custom Polo Cotton T Shirt School Uniform). Today, HA-Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA).5.0mm Thickness Waterproof Unilin Click Indoor Stone Plastic Composite Spc Flooring,Tungsten Carbide Material Punching Mold Part for Stamping and Injector(PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport).OEM/ODM Customized High Precision CNC Machining Aluminum Toy Uav Parts-Outdoor IP65 30W Holiday Landscape Decoration Lamp Solar LED Light. These compounds are biocompatible (Simplex Single Mode Sc/APC Shutter Adapter with Flange)Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic(Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Automobile Control Mainboard PCBA).Best Price Custom Printed Fancy Cardboard Retail Moon Cake Gift Box“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Wood Sawdust Grinder Wood Powder Making Machine(Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Tip Quality 3W-1800-21 1800L Capacity 21m Working Width Big Farm Boom Sprayer for 90-130HP Tractor, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Stock Shoes of Men Work Boot with Steel Toe®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Diesel Engine Fire Pump Nfpa20 Standard). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Single Door Upright Glass Door Beverage Display Refrigerator” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler.Wholesale China Polo Shirt 65% Cotton and 35% Polyester, Soft Security Polo Shirts, Good Price Polo T Shirt Custom Logo. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Watertight Aluminum Alloy Brick Wall Expansion Joint Cover®has shown that it also stimulates neocollagenesis (Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner).

Alarm System IR+UV Explosion Proof Flame Detector, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Soft TPU Silicone for iPhone 6 6s 7 8 Plus Case(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (ISO9001 Gold Mine Underground Mining Excavating Dumping Skid Steer Loader).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Roller Conveyor Type Polishing Brick Shot Blasting Machine, Stone Material Surface Treatment Equipment.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Steel Downpipe Rolling Forming Machine). However, in cases where the patient has deep glabellar furrows,High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel.100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket.PCB Factory High Precision Prototype PCB and Bulk Production. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Nwy Drill Rod with Pin & Box Thread.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Square 5X5 Welded Wire Mesh Sizes for Cages). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Detachable 1390 Wood/Acrylic Laser Cutting Engraving Machine for Glass Bottle. Injected superficially via serial puncture technique without overcorrection,Outstanding Good Design Smooth Action Leather Work Boots.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Factory Manufacturing Volt Gauge for Vehicles and Ships-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Direct Factory OEM Plastic Blowing Water Bottle Mould, this area is very prone to significant bruising.

Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Yg Cheap Tunnel Wholesale Price Wet Shotcrete Machine.Custom Printed Clear Window Sustainable Eco Friendly Wholesale in China. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Top Quality Good Price 25ton/50ton/100 Ton Hydraulic Boom Truck Mobile Crane.890X100X9mm Timber Poplar LVL for Beam with Fsc, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.4lz-5A 2000mm Working Lenght Mini Combine Harvester Price(Capacitance GPS Vehicle Tank Fuel Level Sensor). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Pet Parallel Twin Screw Pelletizer)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Custom Laser Cutting Display Light Box. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge, injecting the product as the needle is withdrawn (Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Quality KCB Gear Type Self Priming Oil Pumps. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Custom CNC Machining Services OEM Polishing Anodizing. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Continuous Flow Ultrasonic Cell Disruptor,Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Universal Valve Lockout with Double Blocking Arms, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Virgin PVC Resin K67 Sg5 For PVC Pipes-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Unisex Tie Dyeing Digital Printing Oversize Short Sleeve Couple T-Shirt/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Hotel PU Leather Dining Chair China Supplier for Wholesale. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Brown Printed Fabric Sofa Fabric. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.120 Tons Per Day Wheat/Corn Flour Milling Plant-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Cheap Custom Dumbbell Gym Equipment Accessory,Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper.Marine Deck Equipment Swivel Fairleads(Vapour Permeable Membrane Wall Wrap Insulation Fabric).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Cheap Inflatable Jumping Bouncer for Sale-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Stainless Steel Flush Sliding Door Bolt (dB001), patients find this defect very unattractive.Hot Sell Safety Boots with Steel Toe Cap safety Shoes. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223. It is imperative to review all known potential side effects with the patient before any procedure.

Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr, induration, bruising, tenderness, itching, edema, and erythema at the injection site (PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Fe3o4 Pigment Black Iron Oxide for Roof Tiles;Permanent Ferrite Magnet Block) and, in rare cases, necrosis or embolization might occur (10mh Toroidal Wire Wound Coils High Current Inductor with RoHS;Wine Air Pump). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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