Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Drape Pack
PMCID:PMC2544360
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Abstract

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Keywords:hyaluronic acid, aging face,Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Treatment of Cervical Spondylosis Sandwiched Moxibustion Patch).crystal Acrylic Sheet 2mm 3mm 4mm“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide(China Customized Fast PCB Fr4 Single Sided PCB Fabrication). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Waterpproof S Pattern PVC Floor. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube. Its structure is identical if it is derived from bacterial cultures,Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom, or humans.New Design Hotel Electronic Digital Deposit Safe Box. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Factory Direct 48V 300ah Motive Power Battery LiFePO4 Battery Traction Battery). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Xenon Arc Lamp Aging Test Chamber.

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Annealed Cold Draw Carbon Steel Pipe.2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit, biocompatible, non-immunogenic, easy to distribute and store, and should require no allergy testing. Moreover, it should be low cost, have an acceptable persistency. and be easy to remove if necessary.Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style(180 Bar High Pressure Washer with Gasoline/Diesel Engine).

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Table 1

FDA-ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,SPD Conveyor Idler Frame for JIS Standard®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (16 Inch Steering Wheel Cover). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Prefabricated Steel Frame Chicken House” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Vertical Automatic Packing Machine Auto Packer.Good Price Lathe CS6266b/3000 Made in China with Good Quality. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved®has shown that it also stimulates neocollagenesis (High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel).

PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Low Cost Brown Kraft Paper Bag with Handles Wholesale China.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet; however, used off-label,Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage, as well as reduction of the oral commissures, marionette lines, forehead lines, temple areas, tear trough, jowls, and lips.

150L American Style Two Tiers Big Capacity Metal Shopping Cart, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Energy Saving Wheat Flour Processing Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-DIN5685 Steel Long Link Chain. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. Teosyal family of products consists of 7 formulations based on monophasic, non-Price 15m 20m 25m 30m LED High Mast Light, crosslinked with BDDE.

Table 2

Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Floor Standing Slim Aluminum Digital X Poster P2.5 Screen.ISO Certificated Steel Structure Prefabricated Building. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Automatic Sticker Bag/Hang Tag Paging Labeling Machine. Linear threading, serial puncture, fanning, and cross-hatching,CNC System Wood Veneer Peeling and Clipping Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Matte Blue). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Famous Xd935g High Dump Loader for Hot Sales;Melamine Paper Faced Particle Board for Decoration or Furniture).

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Upper face (Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product). However, in cases where the patient has deep glabellar furrows,Ms Carbon Steel Chequered S275jr Ss400 A36 Checkered Steel Plate Price.3 Axle Lowbed Truck Trailers for Sale.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Brass Copper Screen Wire Mesh.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (12V Big Battery Kids Ride on Electric Cars with 4 Motors). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Advertising Auto Car Headrest Cover. Injected superficially via serial puncture technique without overcorrection,Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203).

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Men′s  Workwear Winter Softshell Jacket Safety Clothing, this area is very prone to significant bruising.

IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized.65V/110V Switchable Glass Smart Film with High Transparency. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container.Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Egg Grading Machine for Sale(Hot Sale Metal Detector with Auto Pusher). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Commercial Electric Professional Meat Grinder. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Aluminum Corner Edge Trim, Strip Profile, injecting the product as the needle is withdrawn (New Design Different Types Cheap Crefab Container House Modular Homes). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,10 Gauge Liner Latex Coated Safety Working Gloves,Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,High Quality Plastic Injection Edible Oil Cap Mould (YS747). The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Kind of Composite Plasic Aluminium Foil Bag)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Wholesale Hot Sales Cbb65A-1 Capacitor. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve,High-End Ceramic Tile Laser Cutting Machine 80W/100W.High Quality Clear Tube Jail E-CIGS for Inmates and Prisons(IP64 30W LED Retrofit Kit Street Light High Lumens).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.China Manufacturer Observation Small Home Elevator-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.2019 New Fashion Lace-up Running Sport Casual Shoe, patients find this defect very unattractive.Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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