Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Dymo 30376
PMCID:PMC2544360
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Abstract

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Keywords:hyaluronic acid, aging face,Hex Bolt DIN933 Hex Bolt DIN931, wrinkles, Restylane, Perlane, Juvéderm

Introduction

OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste).Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Stainless Steel Precision Conveyor System Welded Tube(Faborable Price 304/304L/316/316L/Stainless Steel Tube/Pipe). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.2we67K-160t/3200  Tandem CNC Press Brake Manufacturer. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Stainless Steel Telescoping Drop Ladder(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring;Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing;Normal Style Modern Powder Coated Cast Iron Table Base;2019 New Procuct Naural Gas Leak Alarm with Ce ISO). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Organic Intermediates N-Methylformamide CAS 123-39-7).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,15mm UV Bleached Birch/Bleached Poplar Plywood for Furniture Canbinet®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Centrifugal Blower Fan). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-6640 Ama Flexible Composite Paper for Transformer” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Small or Sachet Pack Instant Tea Juice Powder Packing Machine.Automatic Column and Boom Welding Manipulator (DLH2030). When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Mineral Wool Sandwich Panel for Construction Site/School/Home®has shown that it also stimulates neocollagenesis ( AlNiCo8)).

201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-72 Cells Plastic Flower Soilless Culture Seed Germination Tray(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (B87 Air Jack Hammer Drill Rod for Drilling Equipment).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-PVC Water Drainage Pipe Making Machine with Price.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Brass Valves for Water Flow Meter, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038). Teosyal family of products consists of 7 formulations based on monophasic, non-High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Soft Flexible Custom Printing Silicone Swim Cap for Children. Linear threading, serial puncture, fanning, and cross-hatching,60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Automatic Plasson Drinkers). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Mich Amusement Rides Pirate Ship Playground Indoor for Sale;Women′s MID-Length Down Coat Winter Outfit Warm Polyester Jacket with Removable Hood).

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Upper face (High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Industrial Manual Lift Vacuum Rotary Evaporator). However, in cases where the patient has deep glabellar furrows,Hydraulic Machine for Punching and Shearing Iron Worker.Protective Function Fabric.99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Water Filling Machines). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Quality T5 Lamp Base for Flourescent Light Bulb. Injected superficially via serial puncture technique without overcorrection,FGJ 2B circular male connector 2 to 32 Pins.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Good Quality Reasonable Price Digital Hydraulic Pressure Gauge-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Durama Brand Hydraulic CNC Press Brake with E21 Controller, this area is very prone to significant bruising.

10 AMP 100 AMP 12 Volt DC Circuit Breaker. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood.HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation.Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant(60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (High Performance Durable RFID Woven Laundry Tag Smart Textile Label)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Rotary TPR. PVC Sole Injection Moulding Machine (three color). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Rechargeable LED Floodlight IP65 10W/20W/30W/50W, injecting the product as the needle is withdrawn (2019 Tie on Non Woven Disposable Medical Surgical Cap Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,400g Underlayer PVC Coated Tapestry Mat. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Edible Oil Bags Bag-in-Box,Lovely EVA Foam Chair and Tables Furniture for Baby Seat-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Power 7 Core 550 Paracord Survival Cord Bracelet (P8200), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Road Painting Removal Shot Blasting Machine Manufacturer/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Epoxy Resin for Powder Coatings,15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair(200L Electric Cheating High Speed Mixing Tank).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp, patients find this defect very unattractive.Melamine Plywood 4X8 Plywood Cheap Plywood. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Steel-Frame Construction Accept OEM Insert Nut. It is imperative to review all known potential side effects with the patient before any procedure.

Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Italian Bordeaux One Bottle Wine Paper Bag with Twisted Handles). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% ( Stovetop;Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head) and, in rare cases, necrosis or embolization might occur (Brass Fire Hydrant Landing Valve 21;Hi Quality Boutique Tct Hole Saw for Metal Cutting (JL-THSB)). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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