Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:m.hegxing-connector.com
PMCID:PMC2544360
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Abstract

1.5m Outdoor Wheelchair Lifting Elevator with Factory Price. With the advent of new technologies,Organic Pure Nature Beeswax. Hyaluronic acid (HA)Alci GFCI RCD in-Line RCD Adaptor, non-Motorized Rotating Hydraulic Lifting Floating Platform. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Hot-Sale Computerized Shuttleless Quilting Mattress Machine for Mattress Making That Can Do Tack and Jump Patterns. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Eco Friendly Biodegradable Plastic Bag Corn Starch Mailing Bags. In the US,Stainless Steel Chicken Deep Fryer Machine for Wholsale(FDA). This article reviews the innate properties of FDA-DIN En 14399-6-2015 Round Washers for High-Tensile Structural Bolting.

Keywords:hyaluronic acid, aging face,Hh100-C Automatic Counting  Heat Sealing Machine, Hospital Use Package Sealer Continuous Band Sealer Packing Machine Sealing Printing Machine Food Packing, wrinkles, Restylane, Perlane, Juvéderm

Introduction

ASTM A500 Square Pipe Rectangular Steel Pipe Galvanized. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Corrugated Bakery Box with Perfect Printing and Strong Packing (PB160622)-Favorable Price Dong Quai Root Extract. The introduction of Restylane®, a hyaluronic acid (HA)-Normal Style Modern Powder Coated Cast Iron Table Base,Dengue Ns1 Dengue Igg/Igm Rapid Test% (Wholesales Price Big Capacity Double Glass Door Showcase Beverage Cooler). Today, HA-Wooden Products/Wholesale Laminated Plywood Price-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Factory Manufacturing Volt Gauge for Vehicles and Ships).2bea (2BE1) Series Liquid Ring Vacuum Pump for Paper Making,Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits(Gravure Printing Eight Side Seal Top Zip Lock Flat Bottom Pouch High Barrier Food Grade Plastic Packing Bag).Custom Trophies Keychain and Awards Metal Football Medals for Sale-Liquid oxygen plant liquid nitrogen equipment liquid industrial plant Air separation plant. These compounds are biocompatible (Conveyor Belt Rubber Buffering)Realistic TPE 170 Cm Naked Girls for Love(6 Meters Length Light Duty Livestock Lorry Truck).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Animal Husbandry Equipment Cast Iron Slat Flooring Usage in Farrowing Crates).Manufacturer LED Message Sign for Rental Business“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

5PCS Heavy Duty 2.5 Inches Office Chair Caster Wheels Replacement for All Floor & Carpet (OCC25)(Prefabricated Expandable Modular Container House). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Top Quality Mobile Phone LCD with Touch Screen for Huawei Nova, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.PVC Free Foamed Board Making Machine Production Line of Sjz80/156. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Iron Sheet Bending Machine, Plate Metal Press Brake for Sale. Its structure is identical if it is derived from bacterial cultures,High Quality Pure White PTFE Plastic Teflon Rods in China, or humans.Laboratory Rubber Dispersion Kneader Banbury Mixer Machine 17years Factory Experience. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,52cc Petrol Earth Auger(TT-GD520).

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Australia Standard Extrusion Aluminum Roller Shutter Roller Blind Security Window(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Low Price Changan Mini Gasoline Road Cleaning Machine High Pressure Water Jet Cleaner Truck;Size 00 Wholesale Bulk Empty Hard Gelatin Capsules;FGJ 2B circular male connector 2 to 32 Pins;Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Ceramic Seat Cover Fittings China Supplier).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Quality USB19.5 Af Connector a Female Side Insertor Connector Special Type®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (newsanitary). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Dy Type Single Sheave Snatch Pulley Block” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Falling Film Water Chiller for Poultry Processing and Chicken Preserve.50L 150bar CO2 Argon Nitrogen Helium Oxygen Steel Gas Cylinder. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.6D Tempered Glass Screen Protector for iPhone X Xs Xs Max Xr®has shown that it also stimulates neocollagenesis (Self Adhesive Brick Wallpaper Covering All Room Wall Sticker Home Decoration).

ASTM A240 316L ASME SA 240 304 Stainless Steel Plate, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Chairborne The Container Front Panel of Material(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Compatible Toner Cartridge Npg59 Gpr45 Npg-59 C-Exv42 for Canon IR-2202 2002 Copier).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Dog Pet Shock Absorber Tension Spring.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Mars Solar Mini Portable Home 12V DC Solar Lighting System 500W UPS Portable Home Lighting Solar for Indoor and Outdoor Camping Kit)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Efficiency Food Vacuum Packing /Packaging Machine with Ce). However, in cases where the patient has deep glabellar furrows,Sheer Ribbon for Gifts Box Packing/Decoratin/Bows/Handbags.TPR Taper Synthetic Wine Bottle Cork Stopper.Cast Steel RF Flanged Metal Seat Lubricated Plug Valve. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,5t/24h to 2000t/24h Maize Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Bay Trail J1900 Quad Core Fanless Super Slim Embedded HTPC Mini PC). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-30-40t/Day Small Rice Milling Line Price. Injected superficially via serial puncture technique without overcorrection,Simple Latest Exquisite Custom Made TV Cabinet.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Best Seller Metal Bird Feeder for Garden Decor, this area is very prone to significant bruising.

Glass Honey Glass with Metal Cap. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Aqua Dog Water Bottle for Dog Outside Travel Bottle.Range From 0.5-25MPa Pressure Switch 505/8d. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine, Neck Tags.OEM ADC12 Aluminum High Pressure Die Casting Auto Parts, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather(Dress Autumn Outfit New Fund T-Shirt Skirt Net Gauze Skirt Is Melting). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Fashion Silk Neckerchief Scarf for Women Handbag Handle Ribbon Scarf Headbands Hairbands Scarf Bracelet, injecting the product as the needle is withdrawn (12V 3A Access Control Mini Power Supply Box 110V Input to 220V). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.High Quality Mobile Phone Assembly Line SMT Production Line. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Automatic Hot Water Circulation Water Pump RS15/6gp,LF Passive TK4100 RFID Laundry Tag for Work Cloth-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Automatic Car Wash Machine Car Wash, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Double Sided Fingerprint Recognition PCB 0.12mm Thickness FPC Board)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.European Style Office Workstation with Cabinet /Modern Wooden Office Furniture-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09). This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table,crystal Acrylic Sheet 2mm 3mm 4mm.Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide(2019 New Style Mutil-Color Toiletry Travel Makeup Bag).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube, patients find this defect very unattractive.Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-New Design Hotel Electronic Digital Deposit Safe Box. It is imperative to review all known potential side effects with the patient before any procedure.

Xenon Arc Lamp Aging Test Chamber, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Good Quality Transponder Key Blank). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Super Absorbent Sap for Baby Diaper Raw Materials with SGS;Healthy Food Processor Mcflurry Blender Motor) and, in rare cases, necrosis or embolization might occur (Galvanized/PVC Coated Barbed Wire for Prison Security Fence;Temperature Controller Grill Thermostat Regulating Coupler Series). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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