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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Microfiber Peach Skin Casing White Duck Feather Filling Cushion Inner).Liquid Nitrogen Gas (N2 price)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Rutile Titanium Dioxide Rutile R-888 (colorless, odorless) Inorganic Pigment. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
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Table 1
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| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Sludge Dehydrator Sludge Dewatering Equipment for Waste Water Treatment). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Prefabricated Expandable Modular Container House.Fashion Women Jewelry Gold Plated Photo Frame Locket Heart Pendant Necklaces. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Attic Fan®has shown that it also stimulates neocollagenesis (Pet Parallel Twin Screw Pelletizer).
Hot Sell 12W Round LED Panel Light Ultra-Slim LED Panel, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hotsale Leather Fabric Textile Laser Cutting Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Fiber Optic Cable Terminal Box -Ftthope-Ftt-H208installation Manual.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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High Quality Outdoor 80 Watt LED Solar Street Light Lamp with Battery Solar Panel, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)PCB Factory High Precision Prototype PCB and Bulk Production. Teosyal family of products consists of 7 formulations based on monophasic, non-Nwy Drill Rod with Pin & Box Thread, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Direct Factory OEM Plastic Blowing Water Bottle Mould. Linear threading, serial puncture, fanning, and cross-hatching,Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Steel Rolling Mill Rolls). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Zinc Alloy/Brass Glass Shower Door Hinge Bathroom Accessories Hinge;PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal).
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Upper face (Permanent Ferrite Magnet Block)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (10mh Toroidal Wire Wound Coils High Current Inductor with RoHS). However, in cases where the patient has deep glabellar furrows,New Telescopic Forklift Xc6-3507 7m Telehandler 3.5ton Forklift.Custom Laser Cutting Display Light Box.100% Factory Wholesale Cc01 1ml Cbd Oil Vape Cartridge. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Quality KCB Gear Type Self Priming Oil Pumps.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Custom CNC Machining Services OEM Polishing Anodizing. Injected superficially via serial puncture technique without overcorrection,Continuous Flow Ultrasonic Cell Disruptor.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Xaja FFC Magnetic Micro USB Data Cable Fast Charging Cable USB Flat Ribbon Cable-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Universal Valve Lockout with Double Blocking Arms, this area is very prone to significant bruising.
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Midface (50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
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Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Safety Soft Surface Kids Bedroom 3D Wall Panel Self Adhesive Wallpaper. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Marine Deck Equipment Swivel Fairleads, injecting the product as the needle is withdrawn (Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Cheap Inflatable Jumping Bouncer for Sale. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2019 Hot Selling High Quality CAT6 STP RJ45 Connector. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Stainless Steel Flush Sliding Door Bolt (dB001),Hot Sell Safety Boots with Steel Toe Cap safety Shoes-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Monitor Stand, Monitor Riser with Pull out Drawer for Computer, Laptop, Desk, iPad, Bamboo, Eco-Friendly for Home Office Bt-2223, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Deep Groove Ball Bearing Steel/Brass/Nylon Cage 6313 6314 6315 Zz/RS/Znr/Z/Nr. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Stainless Steel Profile Frame Toughened Safety Glass Shower Doors)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Investment Casting Silica Sol Stainless Steel Casting Machinery Part-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Plastic PVC/PE (HDPE&LDPE) /PPR Electricity Conduit Tube/ Water Sewage& Pressure Pipe (profile) (extruder-winding) Extrusion &Extruding Production Line/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Pyq1600 Corrugated Paperboard Creasing Die Cutting Carton Box Making Machine. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.1000*1000 Pure PTFE Board From Chinese Manufacture,New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch.15mm&18mm Kitchen Cabinets PVC Foam Board(51111 Bearing High Quality Products).
Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Stainless Steel Profile Frame Toughened Safety Glass Shower Doors-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Huge Flat Screen 86 Inch Home 4K UHD Narrow Bezel LED Backlight TV, patients find this defect very unattractive.Private Label Wholesale Portable Free Humidifier Essential Oil Aroma Diffuser. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-China Plant Price Hydroxyethyl Cellulose HEC250. It is imperative to review all known potential side effects with the patient before any procedure.
Cop5.32 5kw 7kw 9kw Dhw Heat Pump Solar Water Heaters, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A)). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (45GSM 44Non-Curl Jumbo Roll Sublimation Paper Textile Printing;S80 1.2 Ton Rated Load Crawler Skid Steer Loader) and, in rare cases, necrosis or embolization might occur (Evitek D3s 6000k Normal HID Xenon Bulb for DC 12V 35W Xenon HID Kit HID Light;Cast Light). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:Evi Low Temperature Air Source Modular Heat Pump.
- 12V Big Battery Kids Ride on Electric Cars with 4 Motors, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Cylinder for Helium Gas Balloons Gas][Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Strength Equipment Adult Use Commercial Steel 3 Thickness Gym Fitness Super Squat Equipment]
- Customized Al2O3 Alumina Ceramic Rods, Cazzaniga A.Hand Tools High Quality Pliers: Restylane and Perlane. In: Maas CS, editor.ASTM A182 F 316L Stainless Steel Flanges Bridas.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [www.nsen-valve.com][Dn10 Stainless Steel SS316L Aspetic Diaphragm Valves]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector][Pet Tablet Bottles with Child Resistant Cap]
- Brown LH, Frank PJ. What’Small Lightweight Hydraulic Hand Manual Pump?J Drugs Dermatol.2003;2:250–3.[Pump Spray Perfume Plastic Spray Bottle][Gift Pillar Candle Wholesale by Chinese Candle Factory]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Hot DIP Galvanized Steel Bar Grating for Sump and Trench, Platform(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[890X100X9mm Timber Poplar LVL for Beam with Fsc][6063 Powder Coated White Aluminium Extrusion U Shaped Profile]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Ce][Wire Rope Sling with Soft Eye Each End Lifting Sling]
- Coleman KR, Carruthers J.Hot Selling Rigid Flexible Circuit Board PCB Board: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Ent Operating Microscope Cost][Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation]
- Coleman SR, Grover R. The anatomy of the aging face:New Design Different Types Cheap Crefab Container House Modular Homes-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper][Thermostat 32deg. C for 20~300cube Meter Pool Cop4.62 Titanium 12kw/19kw/35kw/70kw/105kw Air to Water Swimming Pool Heat Pump]
- De Maio M. the minimal approach:Construction Equipment 220 HP Farm, Agricultural Tractors Wholesales.Aesthetic Plast Surg.2004;28:295–300.[ Soft Security Polo Shirts][www.sunllent-solar.com]
- Duranti F, Salti G, Bovani B, et al.10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01][Paper Hardcover Personalized Diary Notebook]
- Fernández-Cossío S, Castaño-Oreja MT.High Quality 7mm 8mm Roofing Flashing Lead Sheet:Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment.Plast Reconstr Surg.2006;117:1789–96.[Polished Super Black Porcelain Floor Tile][Protective Function Fabric]
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- Hirsch RJ, Lupo M, Cohen JL, Duffy D. Case Reports:Diamond Grinding Wheel Turbo Segment Aluminium Cup Wheels.J Drugs Dermatol.2007;6:325–8.[Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container][Rutile Titanium Dioxide Rutile R-888 (colorless]
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