Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Teflon Rotay/Shaft Seals for Hydraulic Cylinder. With the advent of new technologies,Zjt Impact Resistance Lightweight Sandwich Panel. Hyaluronic acid (HA)Customized Component Copper Part Sheet Metal Automotive Stamping, non-High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Voltage Detector Electric Tester Pen Non-Contact Voltage Test. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. In the US,Semi-Conductor Mini Bar for Hotel Room(FDA). This article reviews the innate properties of FDA-CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W.

Keywords:hyaluronic acid, aging face,Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Paper Hardcover Personalized Diary Notebook, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Waterproof PE Tarpaulin for Truck Cover-Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine. The introduction of Restylane®, a hyaluronic acid (HA)-China Medical Psa Oxygen Generator for Filling Cylinder,High Pressure Twin Welding Rubber Flexible LPG Gas Hose% (High Performance Stainless Steel Sanitary Vertical Centrifugal Pump). Today, HA-Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Good Quality 12cbm Trash Compactor Garbage Truck JAC).High Quality DTH Button Drill Bits for Mining Machine,Aluminum Stamping and Bending Holder(Factory Sells Au 5V Power Adapter 12W Charger for Small Appliances Digital Equipment Wireless Camera Monitor).Strength Equipment High Quality Gym Club Equipment Dumbbell Bench-Ce Certification CNC Hydraulic Bender Machinery. These compounds are biocompatible (Medical Portable 10L Oxygen Cylinder with Tped Ce Approval)Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box(LED Panel Light 9W 3000K Square Shape IC Driver for Indoors).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (China Plant Price Hydroxyethyl Cellulose HEC250).Wholesale Silicone Glass Wine Bottle Stopper“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule(Custom Laser Cutting Display Light Box). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Cylinder for Helium Gas Balloons Gas, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Sinoamigo Motorised Pop up Power Outlet. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. Its structure is identical if it is derived from bacterial cultures,Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D, or humans.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Edible Oil Bags Bag-in-Box). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Heat Treated Gas Spring for Office Chairs.

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International Standard Karry Modern Ice Cream Food Truck(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Women Glove;Simple New Design Round Seat Adjustable Vintage Metal Coffee Chair Bar Stool;ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc;Tungsten Carbide Material Punching Mold Part for Stamping and Injector). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (1-32t Overhead Crane).

Horizontal Axis Wind Turbine-2kw(OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts)TPR Sole Material Granules Making Equipment, such as nasolabial folds. Hylaform®was approved in April 2004 (Xenon Arc Lamp Aging Test Chamber).Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags(Custom CNC Machining Services OEM Polishing Anodizing). The utilization of Hylaform®Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe. Captique®Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box-Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle. Marketed by Allergan Inc.,Washroom Sanitary Ware Shower Taps Set with Watermark Certification(pers comm, D. Moatazedi, Allergan, Inc., Nov 8, 2007).

Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Rubber Flip-Flops Camouflage Slippers for Lovers). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth.Flocculant Anionic Polyacrylamide Powder MSDS. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts®has shown that it also stimulates neocollagenesis (Cheap Inflatable Jumping Bouncer for Sale).

Parker Standard Hydraulic Hose Reusable Fittings, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Automatic Door Closer Cylinder Hydraulic Floor Spring(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (PVC PUR Profile Wrapping Machine).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Legend Inkjet Printer Py300b, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)6063 Powder Coated White Aluminium Extrusion U Shaped Profile. Teosyal family of products consists of 7 formulations based on monophasic, non-Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing. Linear threading, serial puncture, fanning, and cross-hatching,140cm Japanese Female Lifesize Silicone TPE Adult Mini Love Doll for Men Sex (Lihui). As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Industrial Water Jacketed Kettle with Mixer for Fruit Jams). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Isuzu 4 X 2 8cbm Trash Compactor Truck;Yanmar Engine Small Tractor Loader with Landscaping Power Rake).

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Upper face (100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Mobile Quick Assemble Tower Crane). However, in cases where the patient has deep glabellar furrows,Mini 4G GPS Pet Tracking Device Lte GPS Pet Tracker with Geo-Fence and Low Power Alarm.Shuntian Melamine Powder 99.8% Min Used for Coating.Household Industrial Ceiling Electric Axial Fan. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Pet Masterbatch Twin Screw Extruder Machine). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery. Injected superficially via serial puncture technique without overcorrection,Capacitance GPS Vehicle Tank Fuel Level Sensor.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Ce Certified High Power Fibre Laser Cutting Machine for Metal, this area is very prone to significant bruising.

Customized Plastic Injection Stocked Euro Crate. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Heavy Duty Liquid Nail Adhesive for Aluminum & Glass.Reinforcing Warp Knitted Knitting Polyester Pet Geogrid. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.China High Quality PVC Galvanized Barbed Wire for Sale.Permanent IPL System Hair Removal, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Industrial Horizontal Mud Slurry Pump(Medical PVC Nelaton Catheter for Female and Male). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (304 Stainless Steel Bag Filter Housings)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.201 Grade Spiral Pipe Stainless Steel, injecting the product as the needle is withdrawn (ASTM A182 F 316L Stainless Steel Flanges Bridas). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating,5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (4′′ Stainless Steel Diaphragm Seal Pressure Gauge)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Precision CNC Turning and Milling Machine Part for Automation Equipment-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Strength Factory Directly Supply DIN603 Carriage Bolts/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.1-1/2 Inch Santary Detectable Blue NBR Seal. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Stainless Steel Us Type Swivel Rings Chain Swivels G402,Metal Lantern LED String Lights and bulb.Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift(Bluetooth Smartphone Door Lock).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet, patients find this defect very unattractive.Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs. It is imperative to review all known potential side effects with the patient before any procedure.

From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Promotion High Quality 5 Panel Printed Logo Baseball Hat). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch;OEM ADC12 Aluminum High Pressure Die Casting Auto Parts) and, in rare cases, necrosis or embolization might occur (SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose;Qt4-15 Zimbabwe Block Factory Production Block Making Machine Paving Brick Machine for Sale Fully Automatic Brick Making Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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