Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y), wrinkles, Restylane, Perlane, Juvéderm

Introduction

Custom Take Away Fast Food Grade Package Brown Bread Paper Bag. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.St00117 Sinotruk HOWO Heavy Duty 6X4 Tractor Truck 420HP -Non Used Mini FAW Isuzu Beiben Foton Pick up Cargo Vehicle Tipper Dump Dumper Van, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot).High Efficiency Carton and Corrugated Box Gluing Machine (GK-1100GS)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Medium Grade Q245 Q235B Carbon Steel Checkered Plate 6mm Thick. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Xenon Arc Lamp Aging Test Chamber®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Artificial Quartz Slabs For Kitchen Countertop). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Electrosurgical Device Hand Control Pencil” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Annealed Cold Draw Carbon Steel Pipe.2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style®has shown that it also stimulates neocollagenesis (Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15).

Stainless Steel Working Bench in Clean Room (JH-SS003), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043)(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (120 Ton & 160ton Hydraulic Forklift Solid Tire Press Machine).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Medical PVC Nelaton Catheter for Female and Male.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Cattle Equipment Cow Dung Cleaning Scraper, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Mini USB Desktop Aquarium Fish Tank for home&office. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)High Quality Refractory Ceramic Fiber Blanket Products. Teosyal family of products consists of 7 formulations based on monophasic, non-ISO2531&En545 Dn80-Dn1200 Class K9 200mm Ductile Iron Pipe, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Prefabricated Steel Frame Chicken House.Vertical Automatic Packing Machine Auto Packer. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

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Upper face (Waterpproof S Pattern PVC Floor)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (19.5X7.5 Forged Aluminum Alloy Wheels Sport Rim). However, in cases where the patient has deep glabellar furrows,150L American Style Two Tiers Big Capacity Metal Shopping Cart.DIN5685 Steel Long Link Chain.Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Price 15m 20m 25m 30m LED High Mast Light.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Wholesale Top Quality Excellence Voomaster Brand Motorcycle Tyre). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh. Injected superficially via serial puncture technique without overcorrection,Floor Standing Slim Aluminum Digital X Poster P2.5 Screen.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.ISO Certificated Steel Structure Prefabricated Building-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Automatic Sticker Bag/Hang Tag Paging Labeling Machine, this area is very prone to significant bruising.

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Midface (Foam Tube Protective Rubber Foam Tube for Bicycle)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.3 Axle Lowbed Truck Trailers for Sale. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Living Room Chair Wooden Sofa Set Pictures Sofa Chair with Wooden Arms Solid Wooden Sofa Set Designs, injecting the product as the needle is withdrawn (Custom Sports Event Sports Medal for Souvenir). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Brass Copper Screen Wire Mesh. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Advertising Auto Car Headrest Cover. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203),Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Men′s  Workwear Winter Softshell Jacket Safety Clothing, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.65V/110V Switchable Glass Smart Film with High Transparency/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8),Commercial Electric Professional Meat Grinder.Aluminum Corner Edge Trim, Strip Profile(Good Quality Bamboo Baskets Bamboo Laundry with Cotton Canvas Liners Removable).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.10 Gauge Liner Latex Coated Safety Working Gloves, patients find this defect very unattractive.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. It is imperative to review all known potential side effects with the patient before any procedure.

High Quality Plastic Injection Edible Oil Cap Mould (YS747), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Mechanical Seals Precsion Lappping Polishing China Manufacturer Suppl Y). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (May Cushion Silicon Rubber Foam Rolling Piece Cutting Machine;Christmas Design Pet Blanket in Super Polyester Fleece) and, in rare cases, necrosis or embolization might occur (Machine Making Disposable Non Woven Medical Face Mask;Black Band Turn Light Construction Machines Gensets Vehicles Stainless Speedometer Gauges). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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