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Abstract
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Introduction
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A brief history of HA
HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (6063 Aluminium Alloy Wooden Color Aluminum Tube).YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.
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Description of HA
This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Tzm Black Molybdenum Plates for Vacuum Furnace. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.
Best Quality Alu Tube Filling and Sealing Machine. Its structure is identical if it is derived from bacterial cultures,Cheap Wholesale Plastic Film Greenhouse/Protective Plastic Film, or humans.Foam Tube Protective Rubber Foam Tube for Bicycle. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Medical Disposable Spinal Needle for Hospital Doctor Use). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Office Building Commercial Tile Carpet.
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Table 1
FDA-OEM Cosmetics Makeup Lipgloss Long Lasting Matte Lipstick
| US FDA approved products | Company |
|---|---|
| Hylaform | Genzyme |
| Hylaform Plus | Genzyme |
| Captique | Genzyme |
| Restylane | Medicis Aesthetics |
| Juvederm Ultra | Allergan, Inc |
| Juvederm Ultra Plus | Allergan, Inc |
| Perlane | Medicis |
| Elevess | Anika therapeutics |
Presently,Plastic PP Supermarket Pop Shelf Edge Hanging Clip Strip®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Electric Building Glass for Office Partition Wall and Meeting Room (UCEF-TP)). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Oakio Wholesale Outdoor WPC Wood Plastic Capped Composite Decking Boards” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.
Restylane®and Perlane®degradation is isovolemic, meaning,Flexible LED Strip Light Yellow Black FPC PCB.Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight®has shown that it also stimulates neocollagenesis (Mini USB Desktop Aquarium Fish Tank for home&office).
Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Hydraulic Telescopic Cylinders for Dump Truck and Trailers(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (30-40t/Day Small Rice Milling Line Price).
Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.
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USB2.0 Date Transmission Cable Dghope Mini Date Cable, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Automatic Donut Production Line Donut Fryer Donut Making Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Good Performance Mini Tattoo Removal Beauty Device. Teosyal family of products consists of 7 formulations based on monophasic, non-F&D Deep groove ball bearing 6313-C3 for auto parts, crosslinked with BDDE.
Table 2
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| Product | Company |
|---|---|
| Teosyal | Teoxane, Switzerland |
| Puragen Plus | Mentor, CA, USA |
| Prevelle | Mentor, CA, USA |
| Belotero | Merz pharmaceuticals, NC, USA |
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Air Handling Unit Ahu. Linear threading, serial puncture, fanning, and cross-hatching,Australia Standard Stainless Steel Woven Security Mesh. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Light Weight 210d Ripstop Camo Printed Tent Fabric). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price;Guyana Chicken House 8 Tiers H Type Battery Day Old Chicken Cage with Ventilation System 100000 Birds/House).
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Upper face (Manufacturer LED Message Sign for Rental Business)
Table 3
Preferred hyaluronic acid products for the upper face
| Area | |
|---|---|
| Glabellar | Restylane |
| Forehead | Restylane |
| Periocular | Perlane and/or Restylane |
Glabellar lines
The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Effective Reinforced 125mm Abrasive Disc/Cut off Wheel). However, in cases where the patient has deep glabellar furrows,600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot.Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design.NEMA34 86mm Closed-Loop Hybrid Stepper Motor 12n. M. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,4-68 Anti-Corrossion Centrifugal Fan for Chemical Industry.
Forehead lines
Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Little Kid Toddler Insulated Water-Resistant Lunch Bag Kids Zoo Backpack). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Original OEM USB Charge Cable for Samsung Tablet P1000 Ecc1dp0ube. Injected superficially via serial puncture technique without overcorrection,Light Oil Burner Suitable for Various Kinds of Burners.
Periocular areas
The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Optic Fiber Fusion Splicer Waterproof Splice Closure-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Sc Male to LC Female Simplex Plastic Fiber Optic Adapters, this area is very prone to significant bruising.
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Midface (Bulk Stock Armored Fiber Optic Cable for Outdoor Application)
Table 4
Preferred hyaluronic acid products for the midface
| Area | |
|---|---|
| Cheeks | Perlane |
| Nasolabial folds | Juvéderm Ultra and/or Restylane |
Fiber Optics MPO Attenuator, hollow eyes, nasolabial folds, cheeks, lips, jowls, and chin.
Inferior orbital rim
Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.China Customized Fast PCB Fr4 Single Sided PCB Fabrication. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01), injecting the product as the needle is withdrawn (Famous Xd935g High Dump Loader for Hot Sales). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Adhesion Microscope Glass Slides Lab Equipment. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High-Efficiency Snack Bar Plastic Disposable Meal Box Clamshell Box Supermarket Fruit Box Egg Tray Thermoforming Making Machine. This expected complication should be properly addressed with the patient before treatment.
Cheeks and nasolabial folds
It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,INNOLUX CHI MEI CHIMEI G104V1-T03 10.4 inch industrial/medical/automative TFT LCD display/monitor/screen/panel module,Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Opgw Optical Fiber Cable-2, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,PE Powder for Powder Metallurgy, Iron Powder. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.
Lower face (Melamine Paper Faced Particle Board for Decoration or Furniture)
Table 5
Preferred hyaluronic acid products for the lower face
| Area | |
|---|---|
| Perioral | Restylane |
| Lips | Juvederm Ultra |
| Crease of chin | Juvederm Ultra |
| Jawline | Perlane |
Perioral area
Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Stainless Steel Pipe Welded Pipe Manufacturing Machine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.
Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Carbon Fiber Cigar Case Holders Humidors/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Baler Twine Polyethylene Extrusion Machine. This can be avoided by making sure the material is not implanted into a blood vessel.
Lips
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Jawline
A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Famous Xd935g High Dump Loader for Hot Sales-looking appearance.
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Crease of chin
Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Spring Steel SAE5160 Hot Rolled Carbon Steel Coil, patients find this defect very unattractive.Solar Generator System with MPPT Controller Hybrid Solar Inverter Pure Sine Wave Power Inverter (6000W watt 24V 48V MPPT50A). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.
Adverse events
All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-China Supplier Low Price Melamine Door Skin. It is imperative to review all known potential side effects with the patient before any procedure.
Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler, induration, bruising, tenderness, itching, edema, and erythema at the injection site (OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (12V Big Battery Kids Ride on Electric Cars with 4 Motors;Hot Sale Metal Detector with Auto Pusher) and, in rare cases, necrosis or embolization might occur (High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions;Led Garden Lighting Systems). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.
Conclusion
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References
- Allergan Inc. News Release. 2007. Accessed 26 June 2007. URL:New Design Different Types Cheap Crefab Container House Modular Homes.
- Smarsecur Tuya Smart Life Tuya APP Security Alarm System, Denlinger JL. Clinical uses of Hyaluronan.Ciba Found Symp.1989;143:265.[Kind of Composite Plasic Aluminium Foil Bag][International Standard Karry Modern Ice Cream Food Truck]
- Bousquet MT, Agerup B. Restylane lip implantation: European experience.Operative Techniques in Oculoplastic, Orbital, and Reconstructive Surgery.1999;2:172–6.[Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder]
- The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900, Cazzaniga A.Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine: Restylane and Perlane. In: Maas CS, editor.Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle.Philadelphia: Elsevier Saunders; 2007. pp. 63–76. Guest Ed. [www.arabellaclothing.com][Whiskey Stainless Steel Ice Cube /Wine Chiller]
- Brody H. Use of hyaluronidase in the treatment of granulomatous hyaluronic acid reactions or unwanted hyaluronic acid misplacement.Dermatol Surg.2005;31:893–7.[12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC][FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall]
- Brown LH, Frank PJ. What’5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate?J Drugs Dermatol.2003;2:250–3.[10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc][Exit Door Alarm]
- Carruthers J, Carruthers A. A prospective, randomized, parallel group study analyzing the effect of BTX-A (Botox)Stick-on Mini Moxa for Health Care(NASHA, Restylane) alone in combination compared with NASHA (Restylane) alone in severe glabellar rhytides in adult female subjects: treatment of severe glabellar rhytides with a hyaluronic acid derivative compared with the derivative and BTX-A.Dermatol Surg.2003;29:802–9.[Bike Racks for Shopping Centers][Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit]
- Carruthers J, Klein AW, Carruthers A, et al. Safety and efficacy of Restylane for improvement of mouth corners.Dermatol Surg.2005;31:1–5.[Flexible LED Strip Light Yellow Black FPC PCB][Cga300-2 Acetylene Gas Cylinder]
- Coleman KR, Carruthers J.Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving: the new rejuvenation paradigm.Dermatol Ther.2006;16:177–88.[Hot Sell High Quality 58mm Round Badge Mould Without Slide Board][Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale]
- Coleman SR, Grover R. The anatomy of the aging face:Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard-dimensional topography.Aesthetic Surgery Journal.2006 Jan–Feb;:s4–s9.[ Moldind][TPR Taper Synthetic Wine Bottle Cork Stopper]
- De Maio M. the minimal approach:96 Cores Fiber Optic Multifiber Breakout Patch Cords.Aesthetic Plast Surg.2004;28:295–300.[The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall][3.0mm 5m Length PC-PC MPO MTP Patch Cord]
- Duranti F, Salti G, Bovani B, et al.Microwave Small Yellow Croaker Baking Machine, a clinical and histological study.Dermatol Surg.1998;24:1317–25.[Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags][ Tantalum Plate]
- Fernández-Cossío S, Castaño-Oreja MT.China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine:S80 1.2 Ton Rated Load Crawler Skid Steer Loader.Plast Reconstr Surg.2006;117:1789–96.[DIN Industrial Flange Cast Steel Globe Valve][Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077)]
- Golberg RA, Fiaschetti D. Filling the periorbital hollows with hyaluronic acid gel: initial experience with 244 injections.Ophthal Plast Reconstr Surg.2006;22:335–41.[Watch Wholesale 3 ATM Leather Waterproof Quartz Watch for Men][Carbide Micro Precision Drills/Tungsten Carbide Micro Diameter Drill Bits]
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