Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

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Keywords:hyaluronic acid, aging face,OEM ADC12 Aluminum High Pressure Die Casting Auto Parts, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Goose Feather / White Goose Feather/Natural Raw 95% White Washed Goose Duck Down Feather. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.0.5ton 1 Ton 2 Ton 2.5 Ton 10 FT 20 FT Monorail Electric Chain Hoist, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire-European Style Office Workstation with Cabinet /Modern Wooden Office Furniture. The introduction of Restylane®, a hyaluronic acid (HA)-Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet,2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09)% (Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing). Today, HA-Cast Iron Enamel Gas Burner Stove for Cooking Appliance-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Anion Best Quality Mens Hair Brush (Q20)).High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace,Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table(Isuzu 4 X 2 8cbm Trash Compactor Truck).crystal Acrylic Sheet 2mm 3mm 4mm-Popular Inflatable Long Water Slide / Playground Playing Inflatable Slip N Slide. These compounds are biocompatible (Liquid Silicone Rubber Fridge Magnet Moulding Micro Soft Plastic PVC Injection Molding Machine)Ce Listed 5 Stages RO Water Filter with Big Monitoring Screen(Yanmar Engine Small Tractor Loader with Landscaping Power Rake).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve).New Design Hotel Electronic Digital Deposit Safe Box“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Annealed Cold Draw Carbon Steel Pipe. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit. Its structure is identical if it is derived from bacterial cultures,Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style, or humans.Stainless Steel Working Bench in Clean Room (JH-SS003). Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Mobile Quick Assemble Tower Crane). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Customized Safety Food Grade Rubber Gasket Sealing Ring (SWCPU-R-OR043).

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Table 1

FDA-PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Dairen 1.4 Butanediol Suppliers for Sale). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Low Cost Brown Kraft Paper Bag with Handles Wholesale China” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet.Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.150L American Style Two Tiers Big Capacity Metal Shopping Cart®has shown that it also stimulates neocollagenesis (Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch).

DIN5685 Steel Long Link Chain, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (OEM ADC12 Aluminum High Pressure Die Casting Auto Parts).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Price 15m 20m 25m 30m LED High Mast Light.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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ISO Certificated Steel Structure Prefabricated Building, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (SAE 100r13 Wire Spiral Reinforcement Hydraulic Rubber Hose). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Automatic Sticker Bag/Hang Tag Paging Labeling Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)CNC System Wood Veneer Peeling and Clipping Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-Hot Products Custom Design Good Price Bridal Lace Fabric Wholesale, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Fast Delivery Yinyu 2 Ton Coal Fired Steam Boiler)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Factory Direct Price Digital Luggage Hanging Scale with LCD Display). However, in cases where the patient has deep glabellar furrows,Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule.Men′s  Workwear Winter Softshell Jacket Safety Clothing.IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (China Supplier Low Price Melamine Door Skin). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-65V/110V Switchable Glass Smart Film with High Transparency. Injected superficially via serial puncture technique without overcorrection,Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Egg Grading Machine for Sale, this area is very prone to significant bruising.

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Commercial Electric Professional Meat Grinder.Aluminum Corner Edge Trim, Strip Profile. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector.OEM New Hot Sale Aluminum Alloy Folding Lithium Battery Electric Bike, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.10 Gauge Liner Latex Coated Safety Working Gloves(Customized Component Copper Part Sheet Metal Automotive Stamping). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (10/100/1000m Single Mode Single Fiber Sc20km Media Converter)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.High Quality Plastic Injection Edible Oil Cap Mould (YS747), injecting the product as the needle is withdrawn (Price Epoxy Resin for Wood Prefab Epoxy Resin Kitchen Countertop Polyurethane Epoxy Resin). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Wholesale Hot Sales Cbb65A-1 Capacitor,Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Optic Fiber Fusion Splicer Waterproof Splice Closure)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.High-End Ceramic Tile Laser Cutting Machine 80W/100W-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.High Quality Clear Tube Jail E-CIGS for Inmates and Prisons/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.China Manufacturer Observation Small Home Elevator. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.2019 New Fashion Lace-up Running Sport Casual Shoe-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Slim SMD Garden Spotlight LED Floodlight with White Housing, patients find this defect very unattractive.CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP). Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg. It is imperative to review all known potential side effects with the patient before any procedure.

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Conclusion

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References

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