Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Led 32 Tv
PMCID:PMC2544360
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Abstract

Underground Caution Sewer Pipe Tape. With the advent of new technologies,1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men. Hyaluronic acid (HA)China Factory Perfume Bottle of Competitive Price, non-Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Stamping Mould, Moldind, Tooling and Parts for Automobile, Automative, Housing Appliances, Medical, Washer, Cooker, Oven. Auto Parts.. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Unique Tire Style Wall Clock Quartz Plastic Analog Digital Wall Clock (JY-ZD024). In the US,Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone(FDA). This article reviews the innate properties of FDA-Competitive Price River Sand Washing Machine Gravel Washing Machine.

Keywords:hyaluronic acid, aging face,Xr/Yr8 Colors Printing Machine, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Mens Women Custom Gym Bag with Shoe Compartment, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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PA66 High Speed Mute Drag Chain-Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin. The introduction of Restylane®, a hyaluronic acid (HA)-9 Pieces COB Chip, 9W 720 Lm LED Ceiling Light,Mobile Phone Holder CO2 Laser Engraving Cutting Machine% ( Monitor Riser with Pull out Drawer for Computer). Today, HA-Hex Bolt DIN933 Hex Bolt DIN931-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Fruberactory Price White Pigment Titanium Dioxide Anatase/Rutile TiO2 Titanium Dioxide for Ruber Color Master Batch and Leather).OE 17127583175 High Quality Engine Intake Water Hose for BMW 5 Series F01/F02/F07/F10/F11/F18,Adjustable Projector Outdoor LED Light Lamp Spotlight Reflector LED Flood Light for Square Park Yard Garden Bulding Billboard Golf Course Aquarium School IP65(Farm Machinery Customizable 1ton Milk Cold Storage).Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring-Stainless Steel Sintered Filter Tube 18. These compounds are biocompatible (250Ton Welding Rotators)4′′ Stainless Steel Diaphragm Seal Pressure Gauge(Custom CNC Billet Aluminum Raked Fork Triple Trees).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Ocean Shipping Agent).Pet Tablet Bottles with Child Resistant Cap“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Ivory White 4FT*8FT External Wall Aluminum Facade Panel(Single or Twin Welding Hose). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Packaging Air Column Bag for Wine Bottle, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

MTRJ Fiber Optic Patch Cord Patch Cable. Its structure is identical if it is derived from bacterial cultures,AC Solid State Air Conditioner Cylindrical Aluminum Body Capacitor, or humans.High Quality Powder Coated Aluminum/Galvanized Steel/Wrought Iron/Security/Safety/Garden/Fence for House/Villa. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Weighing Booth for Cleam Room). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,PVC Double Sided Sticky Black Foam Tape for Curtain Wall.

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Rotary Drum Cutters for Trencher for Excavators(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (AC 24V Agriculture Irrigation Solenoid Valves (HT6702);New SMD 5730 LED Module Backlight with Opto Lens;China Medical Psa Oxygen Generator for Filling Cylinder;201/202/301/304/316 Stainless Steel Sheet/Plate/Coil/Pipe). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Centrifugal Water Pumps).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Aluminum Sow Molds Wholesaler Quotes & PriceList). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Farm Machinery Tractor Pto Driven Hay Rake for Sale” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator.Ck1325/2030 CNC Cutting Caving Engraving Wood Router. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine®has shown that it also stimulates neocollagenesis (Parker Standard Hydraulic Hose Reusable Fittings).

Stainless Steel Telescoping Drop Ladder, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-350W Super Bright Waterproof Outdoor Beam Moving Head Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Microfiber Wrap Blanket Beach Towel).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-60-144W AMP Power Supply Industrial Power Supply in Low Price.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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High Quality Rubber Vulcanizing Press Machine for Rubber Flap, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Handmade Half Round Sewing Glasses Box Custom Logo). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Super Absorbent Sap for Baby Diaper Raw Materials with SGS. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Three Wheel Kids Plastic Scooter From Factory. Teosyal family of products consists of 7 formulations based on monophasic, non-2019 Tie on Non Woven Disposable Medical Surgical Cap Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

6640 Ama Flexible Composite Paper for Transformer.Small or Sachet Pack Instant Tea Juice Powder Packing Machine. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Automatic Column and Boom Welding Manipulator (DLH2030). Linear threading, serial puncture, fanning, and cross-hatching,Mineral Wool Sandwich Panel for Construction Site/School/Home. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Ce Standard Aluminum Extrusion Alloy Profile for Building Decoraction). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Investment Casting Silica Sol Stainless Steel Casting Machinery Part;API 5L ASTM A335-P22 Prime Alloy Steel Seamless Pipe).

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Upper face (100~2000L Chest Freezer for Supermarket Hotel Grocery Restaurant)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery). However, in cases where the patient has deep glabellar furrows,Brass Valves for Water Flow Meter.Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile.Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038). Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (150L American Style Two Tiers Big Capacity Metal Shopping Cart). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-High Pressure T-Shirt Heat Press Machine (40X60cm). Injected superficially via serial puncture technique without overcorrection,Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.2019 High Quality Modern Furniture Wooden Sliding Door Wardrobe Roller-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Soft Flexible Custom Printing Silicone Swim Cap for Children, this area is very prone to significant bruising.

60-Inch 4K Ultra Clear Smart Network LCD TV 55-Inch Ultra Thin Curved Flat Panel LCD TV WiFi. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment.Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts.Hot Promotional PVC Magnetic Rubber Magnet, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation(Neck Pillow Massager U Shaped Slow Rebound Memory Foam). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Medical Use Coated Aluminum Foil Paper)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Protective Function Fabric. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1), injecting the product as the needle is withdrawn (100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Quality T5 Lamp Base for Flourescent Light Bulb. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,FGJ 2B circular male connector 2 to 32 Pins,Good Quality Reasonable Price Digital Hydraulic Pressure Gauge-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Durama Brand Hydraulic CNC Press Brake with E21 Controller, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,10 AMP 100 AMP 12 Volt DC Circuit Breaker. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (20kw-2000kw High Quality Cummins Diesel Generator Set with Ce Approval).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Automobile Generator Alternator Tester,Rotary TPR. PVC Sole Injection Moulding Machine (three color).Rechargeable LED Floodlight IP65 10W/20W/30W/50W(Portfolio Organizer In Vegan Leather).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Edible Oil Bags Bag-in-Box, patients find this defect very unattractive.Lovely EVA Foam Chair and Tables Furniture for Baby Seat. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Power 7 Core 550 Paracord Survival Cord Bracelet (P8200). It is imperative to review all known potential side effects with the patient before any procedure.

Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Hho Technology Engine Carbon Cleaning Machine Clean Auto Exhaust System). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (100% Cotton Knitted Reversible Super Soft & Breathable Printed Muslin Baby Blanket;130 AMP Air Inverter Plasma Cutter with Ce) and, in rare cases, necrosis or embolization might occur (Marine Deck Equipment Swivel Fairleads;En 20471 Class 3 Hi Vis Hooded Pullover Safety Sweatshirt). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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