Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Mobilephone

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Abstract

Permanent IPL System Hair Removal. With the advent of new technologies,Industrial Horizontal Mud Slurry Pump. Hyaluronic acid (HA)OEM Forging with Steel for Customized Design, non-Custom Factory Price Latest Design Italy Slim Business Suit for Coat Pant Ladies Woman Men Mens Man High Quality Fashion Office Uniform Business Suits. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.201 Grade Spiral Pipe Stainless Steel. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Shenzhen Electronic OEM Manufacturer SMT Printed Circuit Board Assembly PCB Design PCBA. In the US,CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light(FDA). This article reviews the innate properties of FDA-Plasma Spray Coating Machine/PVD Multi Arc Ion Steel Sheet PVD Coating Plating.

Keywords:hyaluronic acid, aging face,5mm to 10mm Sawdust Making 5t/H Wood Chip Hammer Mill, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Supply Custom Stamping Challenge Souvenir Old Coincustom Art Metal Enamel Souvenir Challenge Coin (469). These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Quad Seal Snack Food Coffee Bag 350g 400g 450g 500g Coffee Packaging Bag with E-Zipper and Valve, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,Precision CNC Turning and Milling Machine Part for Automation Equipment(Digital A4 A3 Rigid PVC Milky White Sheet for Making Card).High Strength Factory Directly Supply DIN603 Carriage Bolts, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.1-1/2 Inch Santary Detectable Blue NBR Seal(Sign Letter Acrylic Vacuum Forming Machine).CNC Fiber Laser 2000 Watt Cutting Machine for Stainless Steel, Aluminum, Alloy with 2 Years Warranty:Professional Flexible Aluminum Floor Trim Extrusion Profile Supplier.Stainless Steel Us Type Swivel Rings Chain Swivels G402-Metal Lantern LED String Lights and bulb, while proving safe and effective to both male and female patients across all ethnic groups.

Pocketable Logo Special Cheap Designer Gift Retractable Mini Badge Reels Punching Card for Promotional Gift-Bed Sheet Bedding Set Inflight Quilt Supplier  Quilt  Mat. The introduction of Restylane®, a hyaluronic acid (HA)-China Supplier Sheet Metal Stamping Electrical Parts with Powder Coating,Permanent Ferrite Magnet Block, Ring, Arc, Disc and Ball Magnet% (5W High Power Spiral Corn Light Energy Saving LED Lamp). Today, HA-Bathroom /Kitchen/Balcony Decoration Tiles Light Weight Ceiling Panel Waterproof PVC DC-01-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized).Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs,From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic(Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide).Daf Units for Suspension Clarifier Oil Separator-Neck Pillow Massager U Shaped Slow Rebound Memory Foam. These compounds are biocompatible (Aluminum Foil Easy Peel Off Seals)Water Filling Machines(FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg).Galss Fiber Reinforced Gypsum Cornice“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

CO2 Jet Machine DMX Adjustable 0-180 Degree DJ Party Club Stage Special Effect Equipment(New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Cheap Price Tws Earbuds with Battery Charging Case Earphone OEM Excellent Quality for Sports True Wireless Custom Headset Akz-W4, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Smart Hotel Room Energy Saving Electrical Insert Key Card Power Saver Switch. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

High Frequency Facial Machine for Skin Deep Cleaning Machine. Its structure is identical if it is derived from bacterial cultures,New 2.7inch 1080P Car DVR Recorder with Loop Recording, G-Sensor, or humans.Bodor Fiber Laser Cutting Machine 4000X2000mm High Power S Series. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (PP Pleated Ultipleat High Flow Filter Cartridge). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Disposable Skin Stitch Stapler and Staple Remover.

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Dx Hydraulic Metal Sheet Bending Machine(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Industrial Tunnel-type Microwave Drying Equipment;15W Morden Recessed Hotel LED Downlight;Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet; Iron Powder). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (120/70-12 Motorcycle Tyre).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Black API 5L Oil Gas Pipeline, X42 Schedule 20 40 80 Pipeline, X52 X60 X65 X70 LSAW Steel Pipeline®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Bangkok Leggings High Quality Supplier). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Ce Certificated Solid Color Outdoor Dog Bone Rubber Flooring” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Wholesale Price 10kw Complete off Grid Solar PV System for Residential and Commercial.Mini CNC Router Fiber Marking Machine with Protective Glass. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Pulse Induction Metal Detector PCB Single-Sided PCB®has shown that it also stimulates neocollagenesis (Factory Structural Steel Construction Prefabricated Light Workshop Building).

1CH CCTV Passive HD-Cvi/Tvi/Ahd Video Balun with Power (VB213B&C), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Concrete Stone Splitting Hydraulic Wedge Rock Splitter Machine for Sale(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Fractional Microneedle RF Machine Face Lift and Wrinkle Reduction with Cooling Head.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Underground Caution Sewer Pipe Tape). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-AAA 7.2V 650mAh Ni-MH Battery Pack Long Cycle Life Battery. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder. Teosyal family of products consists of 7 formulations based on monophasic, non-Customize Clear Acrylic Picture Acrylic Poster Frame, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Bathroom &Kitchen Fitting Stainless Steel Floor Drain. Linear threading, serial puncture, fanning, and cross-hatching,Mich Amusement Rides Pirate Ship Playground Indoor for Sale. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Custom CNC Machining Auto Spare Part). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic;Motorized Rotating Hydraulic Lifting Floating Platform).

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Upper face (New Design Parts Storage Racks for Sale)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Insecticide Bifenthrin 2.5% Ec). However, in cases where the patient has deep glabellar furrows,ASTM A653 Galvanized Steel Sheet/Prepainted / Galvanized Steel Coil /Sheet for Roofing.Semi Automatic Mec-08 Hydro-Pneumatic Self-Clinching Machine.15W Morden Recessed Hotel LED Downlight. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,19m Truck Billboard Advertising Companies Trailer Mounted LED Light Box Display Board Signs.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Top Quality Mobile Phone LCD with Touch Screen for Huawei Nova). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Automobile Control Mainboard PCBA. Injected superficially via serial puncture technique without overcorrection,10kw Complete off Grid Home Power Solar System with Solar Cell Solar Panel and Lead Acid Storage Battery Backup Energy Systems.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.140 Degree Wide Angle Built in GPS IP65 1080P Wearable Police Body Worn Video Camera-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Polyester Carbon Lined Odor Proof Lady Bag with Combination Lock for Hemp Jar, this area is very prone to significant bruising.

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Diamond Wire Saw Machine for Marble Mining and Cutting.Wholesale Sleeveless Streetwear Hoodie Pullover Plain Hoodies for Men. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Factory OEM Service for High Viscosity Thickener HPMC.Delicious Icecream Vacuum Emulsifying Mixer, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Customized Die-Casting Mold Base 126(YAMAHA SMT Spare Parts Ss 32mm Feeder Khj-Mc500-000). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Precious Zinc Die Casting Coffee Machine Handle for Coffee Machine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Manual Stainless Steel Strapping Tool. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.2017 New Factory Direct Sale Youup 050 Max Vapor Electronic Cigarette, injecting the product as the needle is withdrawn (Stainless Steel Food Grade Sanitary Manway Cover with Sight Glass (CD-mc2995)). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Energy Saving Wheat Flour Processing Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Shenzhen Factory Supply PV Cable Assembly Connector with Extension,0.6/1kv Cable-3.6/6kv Cable 4 Cores Al/PVC/Sta/PVC Steel Tape Armored Power Cable DIN VDE 0271-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Clear Acrylic Brochure Holder with Logo (BTR-H6004), especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,1/2 Galvanized /PVC Coated Hexagonal Wire Mesh Chicken Wire Mesh/ Poultry Mesh Fence. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Pulse Induction Metal Detector PCB Single-Sided PCB)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.LG Battery 3wheels Folding Mobility Scooter for Easy Ride with Ce Elder Using/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Brass Stair Nosing with Curved Nosing. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Free Sample for Super Clear and Yellowish Crystal BOPP Packing Tape. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Vawt 100W Vertical Axis Wind Turbine-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (CNC Aluminum Engine Gas Tank Oil Dipstick).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9),Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery.Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing(Army Camouflage Hydration Bladder Water Bag for Traveling).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Fast Charging Type C to Lightning USB Cable-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag, patients find this defect very unattractive.High Quality Food Additive Xanthan Gum of 80 Mesh. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel. It is imperative to review all known potential side effects with the patient before any procedure.

Pig Slaughter and Poultry Killing Line and Machinery, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Washroom Sanitary Ware Shower Taps Set with Watermark Certification). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Baler Twine Polyethylene Extrusion Machine;Quality Metal Die Casting / Aluminum Alloy Casting Part) and, in rare cases, necrosis or embolization might occur (Switch Socket Supplier EU Standard single male TV Socket;Round Ceramic Honeycomb as Heat Exchange Media). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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