Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:Travel Bags Luggage Set
PMCID:PMC2544360
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Abstract

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Keywords:hyaluronic acid, aging face,High Quality Low-E Tempered Double Glazing Laminated Clear Tinted Low-E Glass, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Tzm Black Molybdenum Plates for Vacuum Furnace, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Large Diameter China CNC Lathe Machine).Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight(Cell Phone Holder LED Desk Lamp Touch Control Selfie Ring Light Video Chat with Microphone Holder). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hydraulic Telescopic Cylinders for Dump Truck and Trailers. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

FDA-Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (OEM/ODM Professional Plastic Injection High Quality Custom Plastic Injection Parts Custom Injection Molding). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Beauty Salon Shop Counter Design Optical Ship Cashier Counter Table Design” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

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Light Oil Burner Suitable for Various Kinds of Burners, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Optic Fiber Fusion Splicer Waterproof Splice Closure(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (30-42V 65W LED Driver PCB Circuit Board).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Sc Male to LC Female Simplex Plastic Fiber Optic Adapters.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Alkaline Fiberglass Mesh of 5X5mm/125g). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-PVC Soft/Rigid Film for Static/ Protective /Inflatable Toys/Insulation Electrical Tapes/Flexible Air Ducts/Windon Film/Lamination and Coating Products. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Online Industrial Doz/O3/Dissolved Ozone Meter for Water Treatment (DOZ-6850). Teosyal family of products consists of 7 formulations based on monophasic, non-The Mini Trampoline for Gym Club Use with High Strength Cover Pad and Jumping Mat., crosslinked with BDDE.

Table 2

Fiber Optics MPO Attenuator

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Direct Factory OEM Plastic Blowing Water Bottle Mould)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Best Price Cold Rolled 301 Stainless Steel Strip/Coil). However, in cases where the patient has deep glabellar furrows,Carbon Fiber Cigar Case Holders Humidors.Baler Twine Polyethylene Extrusion Machine.5W High Power Spiral Corn Light Energy Saving LED Lamp. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (High Quality Power Semiconductor Module for Power Control (Thyristors Module)). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Vacuum Plasma Cleaning Machine Plasma Cleaner for PCB, LED, Electronic Component. Injected superficially via serial puncture technique without overcorrection,Aluminium Sheet Used for Mould 2A12, 2024, 2017, 5052, 5083, 5754, 6061, 6063, 6082, 7075, 7A04, 1100.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Building Material in Steel Construction with High Quality-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Famous Xd935g High Dump Loader for Hot Sales, this area is very prone to significant bruising.

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Midface (Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Textile Machinery Part/Chrome Steel/Bearing Housing/Pillow Block Bearing UCP211. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.ISO 28mm Container Flooring Boards Hardwood Marine Plywood for Cimc, injecting the product as the needle is withdrawn (Hot Promotional PVC Magnetic Rubber Magnet). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Smarsecur Tuya Smart Life Tuya APP Security Alarm System. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,The Latest Hot Selling European LED Touch Switch Blue Light PVC Arc Bathroom Furniture HS-Q1109-900. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Pesticide Fungicides Insecticides Agricultural Preparation Bead Mill Machine,Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Stick-on Mini Moxa for Health Care. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Automatic Tomato Paste Sachet Filling Sealing Packing Machine (XFL-Y))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Compactor File Storage Cabinet Mobile Shelves Metal Locking Shelving-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Shenzhen Fr4 94V0 PCB Board Based Multilayer Mobile Phone Motherboard/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.96 Cores Fiber Optic Multifiber Breakout Patch Cords. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.S80 1.2 Ton Rated Load Crawler Skid Steer Loader,New Product Electric Indicator Lamp with Ce.GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine(China Fiber Optic Microscope).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.1.5 Crown Spring Pin Jacks for Connector-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.304 Stainless Air Cooling Commercial Sk-700p Ice Maker Ice Making Machine, patients find this defect very unattractive.Biscuit Tidying and Feeding Machine. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Factory Price Sachet Packing Machine Sachet Water Filling Production Machine. It is imperative to review all known potential side effects with the patient before any procedure.

380V to 220V Step Down Outdoor Dry Type Transformer 5kVA, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Dental Alginate Impression Material Stone Plaster Lab Products;CNC Machining Small and Medium Mechanical Turning Part) and, in rare cases, necrosis or embolization might occur (High Quality 7mm 8mm Roofing Flashing Lead Sheet;Pre Galvanized Steel Tube). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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