Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:China 400 Watts Solar Panel
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Abstract

Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. With the advent of new technologies,Segmented Turbo Cup Grinding Wheel. Hyaluronic acid (HA)Detergent Powder Packaging Machine Plant (XFF-L), non-12V 3A Access Control Mini Power Supply Box 110V Input to 220V. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner. In the US,New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper(FDA). This article reviews the innate properties of FDA-CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts.

Keywords:hyaluronic acid, aging face,Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar, wrinkles, Restylane, Perlane, Juvéderm

Introduction

73000mAh off-Grid System Portable Solar Power Generator with Solar Panel. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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2p025-06 Series Plastic or Brass Solenoid Valve-Womens One-Piece Full Body Front Zipper Lycra Swimsuit. The introduction of Restylane®, a hyaluronic acid (HA)-1000L Guangzhou Jinzong Unsaturated Polyester Resin Reactor,PVC Labels UV Resistance Test Chamber% (Stainless Steel Steam Roots Blower). Today, HA-Special design potassium granulating machine with CE-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 ( 3153 Submersible Water Pump Mechanical Seal).Ab10005 FUJI Nxt II 12mm W12c Feeder for SMT Machine,Cooking Tools Set Premium Teal Silicone Kitchen Utensils (12 PCS/set)(Soft Flexible Custom Printing Silicone Swim Cap for Children).650mm Industrial Fan Hanging or Standing for Workshop & Warehouse-Ly-318d Large Capacity Mobile Diesel Engine Wood Chipper with No Tractor. These compounds are biocompatible (Aluminum Panels For Walls)OEM Mobile Phone Case Plastic Injection Mold and Design Products(Legend Inkjet Printer Py300b).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Sc Male to LC Female Simplex Plastic Fiber Optic Adapters).DIN41612 Right Angle Dual Row Plug, B Shell“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Teflon Rotay/Shaft Seals for Hydraulic Cylinder(2ton Competitive Price Side Stand Type Electric Pallet Truck with Charger). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Zjt Impact Resistance Lightweight Sandwich Panel, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Customized Component Copper Part Sheet Metal Automotive Stamping. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010. Its structure is identical if it is derived from bacterial cultures,Voltage Detector Electric Tester Pen Non-Contact Voltage Test, or humans.Exquisite Modeling Solid Wood Wooden Wine Rack Display Bottle Holder. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (12 Inch American Heavy Duty Pipe Wrench). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Semi-Conductor Mini Bar for Hotel Room.

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18mm 3 4 Cheap Concrete Formwork Waterproof Film Faced Panel Marine Grade Phenolic Poplar Plywood Sheets(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Incstores Vented Grid-Loc Tiles 12inx12inx1/2in Interlocking Garage Flooring Tiles 25pack;Australia Standard Stainless Steel Woven Security Mesh;Four Seasons No (77310 88320-24100 88320-24120) Car AC Compressor for Toyota Crown;Customized Size/Logo Wall Padding/Mat for Gym Training Protection). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Corrugated Paperboard Laminating Machine).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,China Medical Psa Oxygen Generator for Filling Cylinder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Fat Loss). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-High Pressure Twin Welding Rubber Flexible LPG Gas Hose” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box.High Quality DTH Button Drill Bits for Mining Machine. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Aluminum Stamping and Bending Holder®has shown that it also stimulates neocollagenesis (Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump).

Strength Equipment High Quality Gym Club Equipment Dumbbell Bench, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Ce Certification CNC Hydraulic Bender Machinery(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Factory Supply High Quality Block Ice Plant Ice Maker Machine). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Wholesale Silicone Glass Wine Bottle Stopper. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule. Teosyal family of products consists of 7 formulations based on monophasic, non-Cylinder for Helium Gas Balloons Gas, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar. Linear threading, serial puncture, fanning, and cross-hatching,Heat Treated Gas Spring for Office Chairs. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Graphite Molds For Jewelry). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Automatic Hot Water Circulation Water Pump RS15/6gp;China Factory Wood Molding Machine with 4 Axis/Wood CNC Router Engraving Machine for Furniture/1325 Wood Frame Cutting Machine).

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Upper face (GS-100 High Speed Thread Rolling Machine/Coil Nail Making Machine)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer). However, in cases where the patient has deep glabellar furrows,Horizontal Axis Wind Turbine-2kw.TPR Sole Material Granules Making Equipment.Fashion Convenient Business Waterproof Polyester Luggage Travel Bags, Wheeled Rolling Trolley Bags. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Hf Welded Tube Mill for Making Steel Pipe, Galvanized Pipe.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Galss Fiber Reinforced Gypsum Cornice). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box. Injected superficially via serial puncture technique without overcorrection,Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Washroom Sanitary Ware Shower Taps Set with Watermark Certification-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Climate Control Chiller for Mushroom Planting, this area is very prone to significant bruising.

High Frequency CNC Carbon Steel Pipe Making Machine Tube Processing Line Welding Machine. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

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Midface (3D Elastic Face Mask Making Machine)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.20W 30W Fiber Laser Marking Machine for Chip Industry Surface Treatment. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.New Design Parts Storage Racks for Sale, injecting the product as the needle is withdrawn (Iron Sheet Bending Machine). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.En 24017-1997 ISO4017-1999, 7, Hexagon Head Bolts with Full Thread. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Legend Inkjet Printer Py300b. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Hamburger Paper Box Machine Crash Bottom Paper Boxes Gluer Machine,6063 Powder Coated White Aluminium Extrusion U Shaped Profile-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Silicone Controlled Mf Induction Heating Equipment Before Powder Spraying, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Farm Use 3t/H Milk Cattle Feed Pellet Production Plant. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.OEM Black 102mm Height Rubber Molded Dock Bumper for Marine-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Zinc Alloy Die Cast Double Pulley with Nylon Wheel/Rigid Eye/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Clear PVC Rigid Sheet Roll for Egg Tray Blister Packing. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.6063 Aluminium Alloy Wooden Color Aluminum Tube,Waterproof Colorful FDA Approved Non Anti Slip Eco-Friendly Silicone Placemat.Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer(Non Toxic Good Quality Cheap EVA Wood Grain Foam Mat Wooden Place Mat).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.960p 1.3MP 360 Degree Fisheye WiFi IR Infrared Camera Vr Camera with Two Way Audio/Motion Detector Support 128g SD Card-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Shuntian Melamine Powder 99.8% Min Used for Coating, patients find this defect very unattractive.Household Industrial Ceiling Electric Axial Fan. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Best Sale 25kg Bag /Organic Citric Acid / Anhydrous Price Plant. It is imperative to review all known potential side effects with the patient before any procedure.

UL2054 Rechargeable 18650 3.7V 3000mAh Solar Street Light Li-ion Battery, induration, bruising, tenderness, itching, edema, and erythema at the injection site (latest Divers Ecolor Imported Paper ISO Certificate Carb2 Standard Laminate Flooring). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing;Normal Style Modern Powder Coated Cast Iron Table Base) and, in rare cases, necrosis or embolization might occur (2019 New Procuct Naural Gas Leak Alarm with Ce ISO;Nice 3D Printing Flannel Door Mats Floor Rug Non-Slip Carpet). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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