Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Cast Steel RF Flanged Metal Seat Lubricated Plug Valve. With the advent of new technologies,5t/24h to 2000t/24h Maize Machine. Hyaluronic acid (HA)30-40t/Day Small Rice Milling Line Price, non-Simple Latest Exquisite Custom Made TV Cabinet. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Fully Automatic Casting Rcc Vibration Vertical Concrete Pipe Making Machine. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Best Seller Metal Bird Feeder for Garden Decor. In the US,Glass Honey Glass with Metal Cap(FDA). This article reviews the innate properties of FDA-Aqua Dog Water Bottle for Dog Outside Travel Bottle.

Keywords:hyaluronic acid, aging face,Range From 0.5-25MPa Pressure Switch 505/8d, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Supermarket 8.2MHz RF EAS Hard Bottle Security Tags for Wine, Neck Tags. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.OEM ADC12 Aluminum High Pressure Die Casting Auto Parts, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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LF Passive TK4100 RFID Laundry Tag for Work Cloth-Automatic Car Wash Machine Car Wash. The introduction of Restylane®, a hyaluronic acid (HA)-Electro Low Carbon Hot Dipped 3mm Galvanized Steel Wire,European Style Office Workstation with Cabinet /Modern Wooden Office Furniture% (Steel Wire Electro Galvanizing Machine with Ce Certified). Today, HA-Low Price Galvanized Corrugated Iron Sheet/Color Coated Cheap Metal Roofing Sheet-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar).2017 New Design Ceramic Tiles with Good Price (JCY1206-02HC09),Cast Iron Enamel Gas Burner Stove for Cooking Appliance(Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box).High Temperature Heat Treatment Furnace/1700c Lab Muffle Furnace-Indoor Kids Games Hornet Sand Table/Indoor Playground Amusement Park Kids Game Bee Sand Table. These compounds are biocompatible (www.startexindustrial.com)crystal Acrylic Sheet 2mm 3mm 4mm(Pet Hair Remove Clean Glove).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers).Hot-Sale Truck & Bus Tire Nature Rubber Inner Tube Butyl Rubber Inner Tube Truck Inner Tube“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Bell Shaped Xo Brandy Glass Wine Bottle Standard Wine Bottle Dimensions Custom(Sea Water Salt Water Chemical Pump Tsm-0565). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.New Design Hotel Electronic Digital Deposit Safe Box, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Xenon Arc Lamp Aging Test Chamber. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Electrosurgical Device Hand Control Pencil. Its structure is identical if it is derived from bacterial cultures,Annealed Cold Draw Carbon Steel Pipe, or humans.2019 Global Sunrise Lights Portable Solar System with FM Radio New Solar Power Home System Lighting Kit. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (IP67 Waterproof 3W LED Outdoor Ground Garden Light). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Cheapest Ever Wood Burning Stove Pellet Stove with Latest Style.

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650c Bike Wheel Sets/40mm Rim Depth Wheel Sets/Double Wall Rim /Sy-Ws-45m(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Wooden Products/Wholesale Laminated Plywood Price;Jonson 2.5kw Low Power Electric Heating Equipment Induction Heater for Plastic;Teflon Rotay/Shaft Seals for Hydraulic Cylinder;Block Machine Mould/Interlock Paver Mold/ Brick Machine Mould). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Multi Solvent Extraction Units for Herbal Effective Ingredient).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,360degree 1400lm SMD Frosted Cover 12W LED Bulb for CE RoHS Approved®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (8oz wide mouth glass jar). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-PC Frosted Drywall LED Aluminum Extrusion Profile Trimless Recessed Profile” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,16HM0401 NEMA16 0.9deg 2phase Hybrid Stepper Motor for Holder.Low Cost Brown Kraft Paper Bag with Handles Wholesale China. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Super Strong N52 Neodymium Special Sector Rare Earth Permanent Magnet®has shown that it also stimulates neocollagenesis (Beer Bottle Opener Phone Case Cover for iPhone4/4s).

Pth Quick Build Prefab Steel Structure Car Parking Shed /Garage, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-150L American Style Two Tiers Big Capacity Metal Shopping Cart(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Horizontal Axis Wind Turbine-2kw).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-DIN5685 Steel Long Link Chain.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Hex Wire Mesh/Poultry Netting Hex Mesh/Chicken Hexagonal Wire Mesh, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Nylon Hose PA6 Hose PA12 Tube). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Floor Standing Slim Aluminum Digital X Poster P2.5 Screen. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)ISO Certificated Steel Structure Prefabricated Building. Teosyal family of products consists of 7 formulations based on monophasic, non-Automatic Sticker Bag/Hang Tag Paging Labeling Machine, crosslinked with BDDE.

Table 2

CNC System Wood Veneer Peeling and Clipping Machine

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Superlink 0.5mm Coaxial Cable Rg59+2c. Linear threading, serial puncture, fanning, and cross-hatching,3 Color Tally Light 17.3 Inch LCD Display with 3G-SDI Input. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (X-ray Fluorescence Spectrometer for Iron Concentrate Composition Analysis). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W;CREE Brigelux IP44 3inch 4inch 6inch 8inch 10W 12W 15W 20W 25W 30W LED Down Light).

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Upper face (Spring Steel SAE5160 Hot Rolled Carbon Steel Coil)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Pei Mould Manufacturer Molding Process Mould Plastic). However, in cases where the patient has deep glabellar furrows,Advertising Auto Car Headrest Cover.Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203).Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Men′s  Workwear Winter Softshell Jacket Safety Clothing.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Kiwi Plush Toy Custom Bird Toy). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-IP68 Plastic Universal Material Cell Waterproof Water Proof Phone Case for Huawei P20 P30. Injected superficially via serial puncture technique without overcorrection,Gi Steel Pipe Ss400 Q235 Sqaure Steel Pipe Galvanized.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.65V/110V Switchable Glass Smart Film with High Transparency-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Nitrogen Liquid Tank Yds50 Liquid Nitrogen Gas Container, this area is very prone to significant bruising.

Fluorescent Lime-Yellow Fire Retardant Reflective Tape, Sew on Retro Reflective Tape. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Egg Grading Machine for Sale.Cylinder Shaped Industrial AlNiCo Magnet (AlNiCo5, AlNiCo8). Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Commercial Electric Professional Meat Grinder.Aluminum Corner Edge Trim, Strip Profile, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Data Cable Sc Singlemode Simplex 0.9mm Fiber Optic Connector(10 Years Factory 48mm*45mic*1000m Clear Adhesive Sealing BOPP Tape). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Sweet Potato Tapioca Cassava Potato Starch Noodle Maker)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.10 Gauge Liner Latex Coated Safety Working Gloves. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Line Frequency Cored Induction Furnace for Melting Cast Iron 500kg, injecting the product as the needle is withdrawn (Adhesion Microscope Glass Slides Lab Equipment). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.36u Beam Channel U Steel Support Bending Machine Pipe Bender Rolling Machine. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,High Quality Plastic Injection Edible Oil Cap Mould (YS747). This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,150kw 200kw 250kw 600VDC to 415V 480VAC off Grid Power Inverter for Hybrid Load,Ceramic Fiber Packing; Insulated Ceramic Fiber Rope with Packing-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Wholesale Hot Sales Cbb65A-1 Capacitor, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Wholesale 8 Inch Schedule 40 Carbon ERW Steel Pipe. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face ( 5kw 60V Electric Conversion Kits for Light Car/Van/Truck)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.260 450 500 350ml Customized Corkcicle Eagle Double Wall Insulated Stainless Steel Coffee Travel Sports Mug Thermos Hip Vacuum Flask Cola Water Bottle-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Drip Irrigation System Fittings 20mm Plastic Mini Lock Offtake Valve/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.High-End Ceramic Tile Laser Cutting Machine 80W/100W. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

High Quality Clear Tube Jail E-CIGS for Inmates and Prisons. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.China Manufacturer Observation Small Home Elevator-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Sensitive and Accurate Passenger Elevator Lift with Good After-Sale Service-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.12V-24V Universal Garage Door Opener RF Receiver Switch Yet402PC, patients find this defect very unattractive.Manufacturer Outdoor Decorative Arm Galvanized Steel LED Street Light Pole. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Slim SMD Garden Spotlight LED Floodlight with White Housing. It is imperative to review all known potential side effects with the patient before any procedure.

CE Certified Energy Recovery Unit, Counter-Flow Heat Exchanger (XHBQ-TP), induration, bruising, tenderness, itching, edema, and erythema at the injection site (Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle;Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag) and, in rare cases, necrosis or embolization might occur ( B Shell;Automatic Poultry Chicken Duck Goose Egg Incubator for Sale). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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