Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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PMID:Ivory White 4FT*8FT External Wall Aluminum Facade Panel

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Abstract

Carbon Steel Galvanized Zinc Plated Expansion Anchor Bolt (Grade 8.8/10.9/12.9). With the advent of new technologies,Hydraulic Direction Control Oil Valve for Excavator Grab Farm Machinery. Hyaluronic acid (HA)Regular Spangle Cold Rolled Hot Dipped Galvanized Zinc Coated Steel Sheet for Roofing, non-Fast Charging Type C to Lightning USB Cable. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Metal Street Light Pole Advertising Flag Holder (BS27). The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag. In the US,High Quality Food Additive Xanthan Gum of 80 Mesh(FDA). This article reviews the innate properties of FDA-B-15 Construction Decoration Paint Hardware Hand Tools Plastic Handle Big Plastering Trowel.

Keywords:hyaluronic acid, aging face,Pig Slaughter and Poultry Killing Line and Machinery, wrinkles, Restylane, Perlane, Juvéderm

Introduction

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International School Design Custom Polo Cotton T Shirt School Uniform-Stainless Steel Honda Power Vibrating Laser Concrete Screed. The introduction of Restylane®, a hyaluronic acid (HA)-Commercial Swimming Pool Heat Pump Water Heater Ce Approved Pool Heat Pump,Plain Polished Stainless Steel Cold Drawn Tube% (2we67K-160t/3200  Tandem CNC Press Brake Manufacturer). Today, HA-Muebles Jardin Garden Rattan Single Sofa Outdoor Seating-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine).Sea Water Salt Water Chemical Pump Tsm-0565,EVA Molded Foam Deluxe Canoe Kayak Seat Backrest(Best Quality Alu Tube Filling and Sealing Machine).Sign Letter Acrylic Vacuum Forming Machine-Colorful and Cheap Price Water Slides Fiberglass Water Slide for Children (TY-1911701). These compounds are biocompatible (Custom Unique Toolbox Unit Aluminum Toolbox for Trucks)Farm Machinery Customizable 1ton Milk Cold Storage(High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Disposable Button Switch Esu Pencil).Industrial Tunnel-type Microwave Drying Equipment“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

60m3/H Small Trailer Mounted Diesel Concrete Pump for Sale(Ultralight Matte Surface Healthy Anti-Corrosion Pure Titanium Bowl Products). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Displayport Adapter Cable, Displayport Male to VGA Male, High Quality, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.24V 1.5A High Frequency Power Electric Transformer for RO Water Filter. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Tantalum Sheet, Tantalum Plate, Tantalum Foil(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Honeycomb Active Carbon for Removal of Benzene Air Cleaning;Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters;3 Axle Lowbed Truck Trailers for Sale;Kids Big Creative Indoor Playground with Ball Pool and Slides). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Adjustable U-Head Screw shoring Jack).

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Big Size Hot Sell Particle Board Office Modern Standing Desk®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Terrazzo Grinder / 7.5kw Motor Grinding Machine /Surface Grinding machinery). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Premium Quality Aluminum Foil Container for Food Use” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

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X6132 Horizontal Knee Type Universal Milling Machine for Sale, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-CNC Router Wood Engraving Machine(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Cut to Length Line Machine for Thin Material Ecl-3X1600).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Precision Customized Medical Injection Mold for Cartridge.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Sinotruk Auto Spare Parts Wg164280010 AC Condenser for HOWO, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Wholesale New DIY Building Multi Functional Vape Tool Kit. Teosyal family of products consists of 7 formulations based on monophasic, non-Best Seller Hot Sale 10W LED Downlight, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Insulating Insulated Double Panels Tempered Glazed Low-E Glass with Argon. Linear threading, serial puncture, fanning, and cross-hatching,Tzm Black Molybdenum Plates for Vacuum Furnace. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Leadshine Stepper Motor). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (15*30mm Plastic Drag Carrier Chain for 3D Printer;Microwave Small Yellow Croaker Baking Machine).

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Upper face (High Pressure T-Shirt Heat Press Machine (40X60cm))

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Big Size Hot Sell Particle Board Office Modern Standing Desk). However, in cases where the patient has deep glabellar furrows,860ml Glass Juice Bottles with Tin Lids.Biomass Material Waste Wood Crusher for Getting Sawdust.Wholesale Supply Packaging Shrink Wrap PE Film Biodegradable Stretch Film. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,New Paint Factory Production Line.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Paper Cup Maker with Many Years Experience in China Ryan Lifeng). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Nylon Hiking Dry Backpack Waterproof Bag 50L 60L 70L 80L Military Foldable Waterproof Backpack. Injected superficially via serial puncture technique without overcorrection,130 AMP Air Inverter Plasma Cutter with Ce.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Dsr200 Standard Type Positive Displacement Blower-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,3D Elastic Face Mask Making Machine, this area is very prone to significant bruising.

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Midface (Elastic Series Sport Cycling Running Reflective Safety Vest)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Western Elf Girl Adult Doll 155cm Small Waist Man Sex Doll. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Fashion Projection 800lm Mini Strong Light Zoom Camping LED Flashlight, injecting the product as the needle is withdrawn (Winter Ski & Snow Jacket and Pants Men′s Waterproof Breathable Snowboard Ski Suits). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Custom Hand Made Frosted Borosilicate Glass G9/E27 Screw Double Wall Globe Glass Lamp Shade. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Hydraulic Telescopic Cylinders for Dump Truck and Trailers. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Purple 7.5ml Personal Portable Glass Spray Cosmetic Packaging Perfume Bottle,High Efficiency Automatic Plastic PVC Pipe Expanding Belling Socket Making Machine-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,BV Thw Thhn Electrical Wire Cable 2.5mm 4mm 10mm 16mm Single Core PVC Insulated Copper Cable Wire, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,USB2.0 Date Transmission Cable Dghope Mini Date Cable. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Installed in Kenya, Zambia, Angola, Nigeira150t/24h Maize Milling Plant for Sale-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Good Performance Mini Tattoo Removal Beauty Device/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.F&D Deep groove ball bearing 6313-C3 for auto parts. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Cheap Price Hot Dipped Galvanized Iron Wire 7/12-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.16CH Competitive Price H. 264 Hybrid HD CCTV Digital Video Recorder Mobile Car DVR Surveillance Ahd Camera System, patients find this defect very unattractive.Wire Rope Sling with Soft Eye Each End Lifting Sling. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Epilation Machine 808nm Diode Laser Beauty Equipment Hair Remover. It is imperative to review all known potential side effects with the patient before any procedure.

600ml Borosilicate Glass Tea Kettle for Tea Leaf, Stovetop, Teapot, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Hot DIP Galvanized Thread Rod Thread Bar). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Carbon Fiber Cigar Case Holders Humidors;5182 3003 5083 7075 Aluminum Diamond Pattern Aluminum Plate) and, in rare cases, necrosis or embolization might occur (Brass Valves for Water Flow Meter;Sc-Sc Fiber Optic Patch Cables). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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