Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
PMCID:PMC2544360
PMID:7.4V

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Abstract

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Keywords:hyaluronic acid, aging face,Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023), wrinkles, Restylane, Perlane, Juvéderm

Introduction

Precision Large Plastic Injection Molding Mass Production Manufacturer. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Japan NTN 6316 Radial Deep Groove Ball Bearing Price List, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card).Cut to Length Line Machine for Thin Material Ecl-3X1600“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

2019 Hot Sell Normal Plastic Beverage Cap Mould(SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Natural Way to Clean Vegetables, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Insect Netting Plastic Window Screen. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent. Its structure is identical if it is derived from bacterial cultures,Steel Spiral Idlers/Belt Conveyor Roller, or humans.Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Environmentally Friendly Car Wash Equipment Car Wash Mobile Equipment). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Dust Resistance Oil Resistance PVC S Floor in Roll.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,94V0 Air Conditioner Inverter PCB Board®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Glow Powder For Paint). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-New Net Shoes Breathable Soft Sole Sport Shoes Men” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,PVC Drainage Pipe Extrusion Production Machine.FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.1530 Plasma Cutting Machine Stainless Steel Cutting CNC Router China Factory®has shown that it also stimulates neocollagenesis (Sinoamigo Motorised Pop up Power Outlet).

Plastic Laundry Detergent HDPE PP Bottle Blow Molding Machine, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Designer Furniture Office Desk, Modern Office Desk, Executive Office Desk(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Du Dx Tin Platting Metal-Polymer Composite Oilless Bearing Bushing).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-#6 X 3/4 Stainless Truss Head Phillips Wood Screw 18-8 (304) Stainless Steel Screws.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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PCBA-Consumer Electronics PCBA SMT DIP OEM EMS ODM SMD. Linear threading, serial puncture, fanning, and cross-hatching,PTFE/FKM/PU/ NBR/POM/PA Material Hydraulic Cylinder Seal. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Film Capacitor 2.7v). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Square Flanged Unit Ucf215-215 Cast Housing Set Screw Type;Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light).

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Upper face (Industrial Rubber Air Line Compressor 3/8 Inch Flexible Air Hose)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Adjustable Round Dies). However, in cases where the patient has deep glabellar furrows,Udio Video Power Security Camera Cable CCTV DVR Surveillance Cord RCA Cable.Customized Machining 96% Al2O3 and 99% Alumina Ceramic Pipe.Tri-Screw Extruder for Powder Coating. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Cma-Cgm Cargo Transportation From China to Worcester, Ma.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (Cast Iron Enamel Gas Burner Stove for Cooking Appliance). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Baghouse Industrial Dust Collector Manufacturer. Injected superficially via serial puncture technique without overcorrection,50mm Extruded Polystyrene Insulation Board.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Underground Caution Sewer Pipe Tape-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,1PCS/Lot New Coming 10 Speeds Model USB Rechargeable Electric Hands Free Male Full Automatic Masturbator Cup, Sex Toy for Men, this area is very prone to significant bruising.

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Midface (K3185 12 PC Suspension Sway Links and Tie Rod Assembly Set for Jeep)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Duvet Cover Cotton 3cm Stripe Satin Travel Quilts for Airline. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Mens Women Custom Gym Bag with Shoe Compartment, injecting the product as the needle is withdrawn (Hot Selling 12 Pin Data Cable USB 3.1 Type C Wire Connector). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Pump Spray Perfume Plastic Spray Bottle. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Square 5X5 Welded Wire Mesh Sizes for Cages. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Thermal Insulation Calcium Silicate Board Concrete Board Fiber Cement Board,Breathable PU Sole Steel Toe Safety Shoes-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Customizing Galvanized Gestation Sow Stalls Made in China. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Yantai Haige Seven Roll Straightening Machine for China Supplier-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.PA66 High Speed Mute Drag Chain/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Wallet for Women Tassel PU Leather Multi- Slots Girls with Zipper Coin. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Factory Made Homogeneous Ossar PVC Rolls Vinyl Flooring-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.4′′ Stainless Steel Diaphragm Seal Pressure Gauge, patients find this defect very unattractive.PPR Double Female Thread Elbow for Bathroom. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Plastic Nylon POM PA6 Customized CNC Machining for Gear Spare Parts. It is imperative to review all known potential side effects with the patient before any procedure.

Sc/APC Singlemode, Simplex Adapter with Shutter, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Best Price IP65 220V 250W 10m-35 Meter High Mast Floodlight Pole Lamp Outdoor Street LED High Mast Light). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated;380V to 220V Step Down Outdoor Dry Type Transformer 5kVA) and, in rare cases, necrosis or embolization might occur ( Strip Profile;Floor High Pressure Cleaner Supplier & Factory). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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