Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light. With the advent of new technologies,Exterior Aluminum Sun Louvre Roof Pergola Building Shading System. Hyaluronic acid (HA)Weighing Booth for Cleam Room, non-Wholesale Super Soft Extra Cozy Luxury Sherpa Fleece and Flannel Faux Fur Throw Blanket. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Disposable Baby Bib Manufacturer Home and Dental Use. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,45g Carbonless paper/Carbonless paper coating machine paper. In the US,Carved Plastic Flower Pot (KD9901-KD9905)(FDA). This article reviews the innate properties of FDA-Grey Slate Natural Stacked Stone, Wall Stone Veneer with Cement Base.

Keywords:hyaluronic acid, aging face,Custom Good Surface Finish Die Casting Zinc Alloy Parts Chrome-Plated, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Corrugated Paperboard / Cardboard Bursting Strength Tester. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Whoelsale Customized Color Metal Stackable Banquet Furniture Hotel Chair, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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3PCS Funny Ornaments Evening Party Toy Kids-Wholesale Nameplate Custom Design Metal Engraved Logo. The introduction of Restylane®, a hyaluronic acid (HA)-High Quality Cotton Made Long Sleeve Sprots Wear and T-Shirt Fleece Clothing with Zip Coat,Mr417 Roller Plate Rolling Machine with Competitive Price% (Ce Certification CNC Hydraulic Bender Machinery). Today, HA-High Purity Melamine 99.8% Min for Plywood-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (SPD Conveyor Idler Frame for JIS Standard).Tk-4515A Soft Closing Ball Bearing Slide,Stainless Steel Rectangular Tube for Decoration (300SERIES, 200SERIES)(Police Electric Shock Torch Stun Gun/Electric Stun Gun (SYSG-181203)).Pet Parallel Twin Screw Pelletizer-Exdiibt4 Explosion Proof Type 10kw Power Inverter Built in Low Frequency Transformer. These compounds are biocompatible (Cover Plate Boiler Mountings for Biomass/Coal Fired Thermal Oil Boiler with Fast Delivery)Automatic Computer Automotive/Car 3D Wheel Alignment Equipment Manufacturer(PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine).Switch Socket Supplier EU Standard single male TV Socket“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

100W 80W 60W CO2 Laser Cutting Engraving Machine Wood MDF Acrylic Laser Engraving Cutter Industry CNC 3D Paper Card(Customized Copper Metal Stamping Part Small). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Plastic Packaging HDPE 120ml Plastic Medicine Bottle with Plastic Cap, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Kiwi Plush Toy Custom Bird Toy. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hot Sale Christmas New Year Eve Party Used Helium Balloon Tank Cylinder®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Hydraulic Cylinder Spare Parts). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Stainless Steel Inox 904L 2205 1.4462 201 Tube” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Laminated PVC Panel, Printing and Hot Stamping Ceiling Panel.18/20Trolley Luggage Travel Luggage Business Luggage Bag with High Quality. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Nootropics Memory Enhance Galantamine Hydrobromide 1953-04-4 Nootropic Powder®has shown that it also stimulates neocollagenesis ( Tile).

Flexible Hose Connector SAE100r2a/at 1 Inch Rubber Fire Hose, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-AC Single Phase Best Water Pump Motor 1HP Used in Swimming Pool and Pond Pump(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (Shantui Official Manufacturer SD13ys Full-Hydraulic Wetland Bulldozer).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Three-Dimensional Pyramid Type Tea Filter Bag Material PE, polyamide, Nylon, PLA Mesh Degradable.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Wholesale Round Airtight Glass Jar for Storage, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Folding Steel Manual Wheelchair with Powder Coated Frame). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Smooth Scrub PU Imitation Artificial Leather for Shoe Bag Fabric. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)304 Stainless Steel Bag Filter Housings. Teosyal family of products consists of 7 formulations based on monophasic, non-Portable Mini 30W 60W 100W Fiber Laser Cutting Machine Metal Cutter Price, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Upper face (Organic Water Soluble Granular Humic Acid 80% Long Term Fertilizer)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Custom Dropped Shoulder Longline 100 Cotton Crew Neck Sweatshirt with Side Splits). However, in cases where the patient has deep glabellar furrows,Gk-400 Dry Powder Roll-Type Granulation Machine.Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel.China Decras Stone Coated Step Tile Roofing Sheet, Long Span Aluminium Roofing Sheet Price. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Horizontal High Pressure High Chrome Wet End Centrifugal Slurry Pump.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (China Supplier 50 Ton Truck Crane). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Garden Water Supply HDPE Flat Drip Tape Machine for Irrigation. Injected superficially via serial puncture technique without overcorrection,Good Price Nickel Alloy Hastelloy C276 Welding Rod / Bar.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Christmas Gifts Ballet Wear Dance Wear School Supplies Sourcing Agent Service Shipping Agent (C5023)-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Precision Large Plastic Injection Molding Mass Production Manufacturer, this area is very prone to significant bruising.

Japan NTN 6316 Radial Deep Groove Ball Bearing Price List. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

ASME B16.34 A216 Wcb Butt Welded Globe Valve.High Speed Steel Round Bar M42 SKH59 1.3247 for cutter. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Popular Tws Xi9 Earphones Wireless Bt 5.0 Earphone Touch.Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077), the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Car Alloy Wheel Rim Straightening Machine(Health Supplement Anti-Fatigue Garlic Oil Soft Gel Capsule). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface ( with Chair Custom Promotional)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Acrylic/Plastic/Wood /PVC Board/1600*1000 CO2 Laser Cutting Machine. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Factory Price Auto Bearing Durable Long Life 6311 6312 6313 6314 6315 6316 6317 6318 6319 6320 Open/Zz/2RS Deep Groove Ball Bearing, injecting the product as the needle is withdrawn (Medical Disposable Absorbable Sterile Collagen Suture Raw Material USP5/0). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Laminated Insulating Tempered Safety Float Sandwich Railing Glass. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,2-Way Brass Electric Valve Ball AC220V Dn25 1. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Mesh Milanese Stainless Steel Wristwatch Band 1.0mm,15*30mm Plastic Drag Carrier Chain for 3D Printer-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Custom Stainless Steel / Carbon Steel Sheet Metal Anodized Stamping Bending Parts, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,480V to 400V Step Down 3 Phase Transformer. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Sign Letter Acrylic Vacuum Forming Machine)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Power Transformer Of Oil Immersed/Dry Type (oil on-load/non-excitation tap-changing)-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Grey Cute Plush High Quality Cat Soft Stuffed CE Toy/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Electrical Power Fine Stone Concrete Pump with High Efficiency. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Juice Filling and Capping Machine Vegetable Juice Machinery Fruit Juice Manufacturing Equipmentfruit Juice Processing Equipmentfruit Juice Bottling Machine,Cut to Length Line Machine for Thin Material Ecl-3X1600.2019 Hot Sell Normal Plastic Beverage Cap Mould(3 Way Shutoff 24V Air Control Pneumatic Solenoid Valve).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Natural Way to Clean Vegetables-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Easy Build Modular Prefab Steel Structure Chicken Farming House Design Agent, patients find this defect very unattractive.Steel Spiral Idlers/Belt Conveyor Roller. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Butterfly Valve Double Flange BS5155 S13 with Vulcanized Seat. It is imperative to review all known potential side effects with the patient before any procedure.

Dust Resistance Oil Resistance PVC S Floor in Roll, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Anti-Theft 12000mAh Wireless GPS/GSM Tracker with Magnetic Easy Hide). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (FRP Refrigerated Freezer Truck Body for Fresh Vegetable and Seafood;A234 Wpb ASME B16.9 Black Butt Welding Elbow 45 Deg) and, in rare cases, necrosis or embolization might occur (New Design Wide Stripe Rayon Polyester Woven Fabric with Stretch;925 Sterling Silver Necklace). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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