Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:m.willingtire.com

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Abstract

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Keywords:hyaluronic acid, aging face,Stainless Steel Precision Conveyor System Welded Tube, wrinkles, Restylane, Perlane, Juvéderm

Introduction

PCBA GPS Tracker Mini Tracker PCBA Circuit Board with One Stop Service. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.2we67K-160t/3200  Tandem CNC Press Brake Manufacturer, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine-Stainless Steel Telescoping Drop Ladder. The introduction of Restylane®, a hyaluronic acid (HA)-350W Super Bright Waterproof Outdoor Beam Moving Head Light,60-144W AMP Power Supply Industrial Power Supply in Low Price% (350W Super Bright Waterproof Outdoor Beam Moving Head Light). Today, HA-Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (100% Polyester Weft Knit Suede Fabric for Garment and Shoes).Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies,High Quality Rubber Vulcanizing Press Machine for Rubber Flap(Good Price Lathe CS6266b/3000 Made in China with Good Quality).Super Absorbent Sap for Baby Diaper Raw Materials with SGS-Three Wheel Kids Plastic Scooter From Factory. These compounds are biocompatible (Low Price High Quality R25 R28 R32 Thread Connection Coupling Sleeves)2019 Tie on Non Woven Disposable Medical Surgical Cap Machine(Private Label Organic Ingredient Gift Set Flower Petal Ladies Bomb Mix Color Bath Bombs).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (EVA Molded Foam Deluxe Canoe Kayak Seat Backrest).Automatic Column and Boom Welding Manipulator (DLH2030)“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Mineral Wool Sandwich Panel for Construction Site/School/Home(Double Screw Extruder Water-Ring Granulation Line). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.201/304/304L/316/316L 2b/Ba Surface Stainless Hr/Cr Steel Coil/Strip, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.72 Cells Plastic Flower Soilless Culture Seed Germination Tray. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

PVC Water Drainage Pipe Making Machine with Price. Its structure is identical if it is derived from bacterial cultures,Factory Supply High Quality Block Ice Plant Ice Maker Machine, or humans.Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (Sharpy 230 Beam Moving Head Light Beam 230 7r Moving Head Stage Light). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Brass Valves for Water Flow Meter.

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Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Beanie Hat & Scarf Production Machine.;Environmental Construction Materials Marble Coated Aluminum Panels;1000*1000 Pure PTFE Board From Chinese Manufacture;Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (China Archway Metal Detector Gate).

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Table 1

FDA-Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Hydraulic Machine for Punching and Shearing Iron Worker®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Backward Curved Impellers High Quality Supplier). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Protective Function Fabric” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1).Hihg Precision Standard Ball Slider for Guide Bushing Ball Retainer. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.High Quality T5 Lamp Base for Flourescent Light Bulb®has shown that it also stimulates neocollagenesis (ASME B16.34 A216 Wcb Butt Welded Globe Valve).

FGJ 2B circular male connector 2 to 32 Pins, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Good Quality Reasonable Price Digital Hydraulic Pressure Gauge(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1)).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Durama Brand Hydraulic CNC Press Brake with E21 Controller.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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HDPE Transparent Anti Insect Mesh Nets for Agriculture Greenhouse Anti Insect Net, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Stainless Steel Round Filter Discs Perforated 304 Screen Metal Piece). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-Rcyb High Intensity Suspended Iron Separator for Magnetic Metal Separation. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Manual Earth Auger, Tractor Post Hole Digger, Ground Earth Drill. Teosyal family of products consists of 7 formulations based on monophasic, non-Plastic A4 Size Files Safety Box with Strong Fire Resistant Water Resistant, crosslinked with BDDE.

Table 2

Automobile Generator Alternator Tester

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price. Linear threading, serial puncture, fanning, and cross-hatching,400g Underlayer PVC Coated Tapestry Mat. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (20 Pcs Dental Sterilizing Cassette). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (X6132 Horizontal Knee Type Universal Milling Machine for Sale;Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies).

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Upper face (10W IP44 Warranty 5 Years CREE COB Meeting Room Ceiling LED Downlight)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Stainless Steel Chicken Deep Fryer Machine for Wholsale). However, in cases where the patient has deep glabellar furrows,Road Painting Removal Shot Blasting Machine Manufacturer.Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,for Phone X Covers 256GB Mobile Phone.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (3mm White Fancy Paper Laminated MDF). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Epoxy Resin for Powder Coatings. Injected superficially via serial puncture technique without overcorrection,15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15, this area is very prone to significant bruising.

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1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp.Melamine Plywood 4X8 Plywood Cheap Plywood. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Steel-Frame Construction Accept OEM Insert Nut.Ce RoHS FCC Digital Flexible LED Video Wall for Stage LED Wall Concert Touring Show Advertising LED Wall, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24(Large Mechanical Roll up Door Warehouse for Storage (TSU-2630/TSU-2652/TSU-2682)). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (0.5W 4.7V Mini SMT Sunpower Solar Panel (SMT-0.5-01))

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.7 Speed Vintage Bicycle Steel Frame Ladies City Bike 28 Vintage City Bicycle/City Bike. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Hotel Electric Kettle, injecting the product as the needle is withdrawn (2017 EPA Approved Mini Go Karts/Dune Buggy/ATV with Ce for Kids). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,New Type Portable Mortar Concrete Pump for Sale. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Flat Plate High Pressure Split Blue Absorber Solar Collector,Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,High Standard Customized Sheet Metal Aluminum Machine Base, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Beech Veneer Fancy Plywood for Furniture. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Vertical Automatic Packing Machine Auto Packer)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Colorful Flocking Powder on Nail-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Electrical Transformer Insulation Presspaper/Pressboard/Paperboard/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (LED Downlight 7W 3.5inch 180-240V 118X58mm with Ce RoHS Warranty 3 Years IP44).

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Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Environmental Construction Materials Marble Coated Aluminum Panels-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Quantum Energy Pendant with Figure and OEM Logo, patients find this defect very unattractive.Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product. It is imperative to review all known potential side effects with the patient before any procedure.

Universal Car Travel Inflatable Mattress Air Bed, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Diamond Wire Saw Machine for Marble Mining and Cutting). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Impa Marine 3/8/12 Strand Mixed PP&Polyester Pet Mooring Rope for Vessel;Floor Standing Slim Aluminum Digital X Poster P2.5 Screen) and, in rare cases, necrosis or embolization might occur (Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale;Jeans Label with Bird Sharp). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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