Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Submersible Vertical Electric 40HP Hydraulic Slurry Pump for Excavator. With the advent of new technologies,Ck1325/2030 CNC Cutting Caving Engraving Wood Router. Hyaluronic acid (HA)Plastic PP/PE/ABS/PVC Thick Plate/Sheet/Board Extrusion Machine, non-Stainless Steel Telescoping Drop Ladder. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.350W Super Bright Waterproof Outdoor Beam Moving Head Light. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,60-144W AMP Power Supply Industrial Power Supply in Low Price. In the US,Chill Tube Cooling Towel Brand New Instant Cooling Towel for Gym(FDA). This article reviews the innate properties of FDA-Yiwu Professional Custom Fashion Jewelry Butterfly Rhinestone Brooch for Ladies.

Keywords:hyaluronic acid, aging face,High Quality Rubber Vulcanizing Press Machine for Rubber Flap, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Super Absorbent Sap for Baby Diaper Raw Materials with SGS. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Three Wheel Kids Plastic Scooter From Factory, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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72 Cells Plastic Flower Soilless Culture Seed Germination Tray-PVC Water Drainage Pipe Making Machine with Price. The introduction of Restylane®, a hyaluronic acid (HA)-Factory Supply High Quality Block Ice Plant Ice Maker Machine,Guangli Ce Approved Hot Sale Car Body Spray Paint Booth with Competitive Price% (Bulk Stock Armored Fiber Optic Cable for Outdoor Application). Today, HA-Brass Valves for Water Flow Meter-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Famous Xd935g High Dump Loader for Hot Sales).Core Drill Electroplate Diamond Hole Saw for Glass, Marble, Tile,Webbing and Genuine Leather Belt Man Leisure Golf Belt (SR-13038)(Melamine Paper Faced Particle Board for Decoration or Furniture).High Quality Gasoline Brush Cutter/Grass Trimmer/Weeding Machine-High Pressure T-Shirt Heat Press Machine (40X60cm). These compounds are biocompatible (SKODA)Boom Lift 7 Meter / 14 Meter Rated Load 3000 Kg / 3500kg Compact Telescopic Handler(Breathable Rayon/Spandex Cotton Knitted Single Jersey Fabric for T-Shirt/Sportswear).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Tesla Style Battery 48V 100ah 200ah 300ah LiFePO4 Battery 6 Kwh 10kwh Solar Energy Storage Powerwall Battery for Home Use).Hot Sale Funny Popular Indoor Kids Plastic Ice Theme Playground Equipment“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Diamond Without Core Drill/Diamond Coreless Drill/Diamond No Core Drill(OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.Replacement Kobelco Oil Filter (P-CE13-533) for Spare Parts, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.Hot Promotional PVC Magnetic Rubber Magnet. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Pesticide Insecticide Powder 60% Wp Nitenpyram Formulation. Its structure is identical if it is derived from bacterial cultures,Hydraulic Machine for Punching and Shearing Iron Worker, or humans.Protective Function Fabric. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism (12V Big Battery Kids Ride on Electric Cars with 4 Motors). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,99% Al2O3 Ceramic Wire Guide Pulley Wheel for Wire Drawing (TC09-1).

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Durama Brand Hydraulic CNC Press Brake with E21 Controller(Vitrase®; ISTA Pharmaceuticals, CA, USA) into the concerned area (Hot Sale Metal Detector with Auto Pusher;High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions;New Design Different Types Cheap Crefab Container House Modular Homes;Kind of Composite Plasic Aluminium Foil Bag). Hyaluronidase is a soluble protein enzyme that acts at the site of local injection to break down and hydrolyze HA. These important characteristics have made HA-based cosmetic injections the second most popular non-surgical procedure for women and the third most popular procedure for men in 2006 (Injection Molding Manufacturers).

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Table 1

FDA-Rotary TPR. PVC Sole Injection Moulding Machine (three color)

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Rechargeable LED Floodlight IP65 10W/20W/30W/50W®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (18.5 Inch Lifting Touch Screen Conference Desk LCD Monitor Lift for Paperless Conference System). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-Mirror Etching Elevator Cabin Decoration Passenger Lift with Good Price” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,400g Underlayer PVC Coated Tapestry Mat.Edible Oil Bags Bag-in-Box. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Lovely EVA Foam Chair and Tables Furniture for Baby Seat®has shown that it also stimulates neocollagenesis (FUJI Vvvf Auto Start Escalator for Cheap Price in Shopping Mall).

Power 7 Core 550 Paracord Survival Cord Bracelet (P8200), Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (10HP Danfoss Air Conditioner Scroll Compressor Sm120s4vc).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Bike Racks for Shopping Centers). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-for Phone X Covers 256GB Mobile Phone. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Epoxy Resin for Powder Coatings. Teosyal family of products consists of 7 formulations based on monophasic, non-15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15.New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

1500W Rectangle Full Spectrum COB Indoor Hydroponics Plant Grow Lights for Green Plant LED Bulb Growth Lamp. Linear threading, serial puncture, fanning, and cross-hatching,Melamine Plywood 4X8 Plywood Cheap Plywood. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Metal Shelf Brackets). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Flexible LED Strip Light Yellow Black FPC PCB;Cga300-2 Acetylene Gas Cylinder).

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Upper face ( Moldind)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (TPR Taper Synthetic Wine Bottle Cork Stopper). However, in cases where the patient has deep glabellar furrows,Hotel Electric Kettle.Polished Volakas/Calacatta/Cararra/White/Snow Marble Slab/Table/Vanitytop Kitchen Bathroom Building Material Wholesale.New Type Portable Mortar Concrete Pump for Sale. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Flat Plate High Pressure Split Blue Absorber Solar Collector.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (The Latest Ultra Narrow Bezel 1.8mm LCD Video Wall). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Small Hydraulic Jack Hammer, Excavator Hydraulic Breaker. Injected superficially via serial puncture technique without overcorrection,High Standard Customized Sheet Metal Aluminum Machine Base.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Beech Veneer Fancy Plywood for Furniture-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Colorful Flocking Powder on Nail, this area is very prone to significant bruising.

Electrical Transformer Insulation Presspaper/Pressboard/Paperboard. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Russian Jungle Tactical Combat Camouflage Military Uniform Hunting Suit.10 Inch Rearview Mirror 4G GPS Navigator HD1080p Dash Cam. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Usun Model: Ulyp -618 Safety Auto Feeding Hydraulic Inserting Machine with Different Fasteners Hydraulic.Warehouse Storage Transportation Stacking Steel Metal Pallets, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.IP67 Waterproof 3W LED Outdoor Ground Garden Light(Inventory Checking Self Adhesive Passive Paper UHF RFID Tag UHF Tags). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface ( Tantalum Plate)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Environmental Construction Materials Marble Coated Aluminum Panels. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.20L Retro Cooler Box with Bottle Opener, injecting the product as the needle is withdrawn (DIN Industrial Flange Cast Steel Globe Valve). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Quantum Energy Pendant with Figure and OEM Logo. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Parts of Motorcycle Cdi/Regulator/Stator Coil Spare Parts for Genesis Motorrycles and Scooters. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,OEM Sheet Metal Forming/Spinning/Stamping Home Furniture Cabinet for Household Appliance Product,Universal Car Travel Inflatable Mattress Air Bed-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Belt Filter Press Filter Screen Filter Cloth for Paper Mill Plant, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Kind of Composite Plasic Aluminium Foil Bag. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Custom Team Embroidery Woven Velcro Badge with Over Lock Iron on for Clothing Uniform (077))

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Food Grade Biodegradable Kraft Take Away Disposable Hot Soup Bowls-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.300X600 Rough Surface Full Body Porcelain Floor Wall Tiles/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.Brass Chrome Square Design Basin Sanitary Ware Bottle Trap for Waste. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

P10 High Brightness Energy Saving Full Color Outdoor Fixed LED Display Screen for Advertising. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.Military Vehicles Water-Washing-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Chairborne The Container Front Panel of Material).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Athletic Clothing Sport Workout Custom Yoga Bra Women Sport Bra,100ml White Glass Cosmetic Cream Packaging Opal Glass Jar with Screw Lid.Detergent Grade Sodium Tripolyphosphate 94% CAS No: 7758-79-4(Dual Arm Monitor Stand).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.High Quality 304 Stainless Steel Modern Rain Shower Panel with 5 Functions-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.High Quality Cbb61 Capacitor for Fan, patients find this defect very unattractive.1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-JIANJUN Fully Computerized Selected Terry Socks Knitting Machine. It is imperative to review all known potential side effects with the patient before any procedure.

CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Bidi 1490nm/1550nm SFP Module LC Connector Simplex 1.25g-SFP-60km). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Stainless Steel Steam Roots Blower; 3153 Submersible Water Pump Mechanical Seal) and, in rare cases, necrosis or embolization might occur (Soft Flexible Custom Printing Silicone Swim Cap for Children;Ceramic Water Reducer). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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