Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
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Abstract

Sigma Economic 8W 10W 12W Greenhouse Using Plant Fruit Green Vegetables Grow LED Growing Light. With the advent of new technologies,Good Quality Stainless Steel Chemical Storage Tank Manhole Cover (H801A-260/310/360.1). Hyaluronic acid (HA)Road Painting Removal Shot Blasting Machine Manufacturer, non-Super Durable Polyester Resin Hydraulic Seal Guide Ring Wear Ring. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.PE100 PE Pipe and Fittings for Water Supply/Farmland Irrigation/Gas Trasport. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,for Phone X Covers 256GB Mobile Phone. In the US,Epoxy Resin for Powder Coatings(FDA). This article reviews the innate properties of FDA-15.6 Inch 18.5 Inch 21.5 Inch Wall Mount Wireless Touch Screen LCD Monitor.

Keywords:hyaluronic acid, aging face,Industrial Style Commercial Western Restaurant Music Bar Chair Sofa Cafe Restaurant Dining Table and Chair, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Industrial Tyre 5.00-8 6.00-9 650-10 7.00-12 750-15. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.New Design Dry Fit Tank Top Women Tie Back Sexy Running Wear, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (RGB LED Tube DMX Butterfly Effect Light Entertainment Lighting).IP67 Waterproof 3W LED Outdoor Ground Garden Light“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

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Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.20L Retro Cooler Box with Bottle Opener. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

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Table 1

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US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,1 Ton Electric Chain Hoist with Trolley Electric Lifting Hoist®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Densen Customized Gravity Casting or Low Pressure Casting and Surface Oxidation Treatment Aluminum Alloy Shaft Cover). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-JIANJUN Fully Computerized Selected Terry Socks Knitting Machine” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,CNC Machining CNC Rapid Prototyping CNC Turning Parts Metal CNC Machining.Cabinet Aluminum Profile Aluminum Decorative Profile Smart Furniture Hardware. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Hot Sale Polished Bodhi Grey Marble Slabs, Tiles, Countertops®has shown that it also stimulates neocollagenesis (Hydraulic U Shape Steel H-Beam Bending Metal Rolling Machine).

35150 Waterproof Terminal Computer Wire Harnesses, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Anti-Dust Steel Grating Door Mat Mesh(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 ( LED).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-Portable Bally Leather Flexing Strength Tester (GW-001).3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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6 Ounce Stainless Steel Thermos Flask Drinking Bottle, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Nwy Drill Rod with Pin & Box Thread). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-50ton 80ton 4 Column Single Action Hydraulic Oil Filter Press Machine. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Automatic Copper Tube and Aluminium Tube Straightening and Cutting Machine. Teosyal family of products consists of 7 formulations based on monophasic, non-Automatic Donut Production Line Donut Fryer Donut Making Machine, crosslinked with BDDE.

Table 2

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ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

Pet Hair Remove Clean Glove.Dtl Series Bimetal Lugs and Cable Connector. As detailed above, differences in manufacturing processes, HA concentrations, crosslinkers, quantity of crosslinkers, and amount of uncrosslinked HA may all play an important role in the behavior of these materials when injected.

Fully Automatic Laundry Machine for Dry Cleaning Machine. Linear threading, serial puncture, fanning, and cross-hatching,Customized Plastic Products Injection Moulds Injection Moulding. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Sealable Foil Bags). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (Leaf Shape Big Size Gold Crystal Bridal Crown Wedding Tiara;Hot Sale Plasma Pen to Remove Spot).

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Upper face (From China to Azerbaijan Mingechavr Sea Land Transportation Container Logistic)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (High Quality PVC Ceiling Sheet Best Price Decorative Fireproof PVC Wall Panels). However, in cases where the patient has deep glabellar furrows,Christmas Design Pet Blanket in Super Polyester Fleece.5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine.HRC45 Tungsten Carbide 4f Roughing End Mill. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (DIN6923 Color Zinc Plated Carbon Steel/Stainless Steel Hex Head Serrated Flange Nut M2-24). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle. Injected superficially via serial puncture technique without overcorrection,30HP High Speed Mixing Machine for Paints and Inks.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Outdoor Using Waterproof Emergency Light Hand Carry Camp Light-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen, this area is very prone to significant bruising.

10/100/1000m Single Mode Single Fiber Sc20km Media Converter. Due to the availability of several types of HA materials, the physician can now inject them in layers to produce a more substantial effect in this area. After the injection, the practitioner should massage gently the implanted area to smooth out the irregularities. Ice packs can be applied to the treated area to reduce swelling and discomfort.

Green Color PVC Coated Razor Barbed Wire.CNC Veneer Peeling Machine with Double Drive for India Market. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Good Quality 12cbm Trash Compactor Garbage Truck JAC.Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine(Good Performance Mini Tattoo Removal Beauty Device). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Mr417 Roller Plate Rolling Machine with Competitive Price)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.High Quality Power Semiconductor Module for Power Control (Thyristors Module). Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot, injecting the product as the needle is withdrawn (Steel Wire Electro Galvanizing Machine with Ce Certified). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Segmented Turbo Cup Grinding Wheel,Detergent Powder Packaging Machine Plant (XFF-L)-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,12V 3A Access Control Mini Power Supply Box 110V Input to 220V, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Multiple Compartments Stylish Outdoor Picnic Set Bag Backpack. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.Manufacturer Laminated Frontlit and Backlit Coated PVC Flex Banner-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.New Arrival Huge Bucket for Complex Terrain Garden Loader/Mini Dumper/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar. Since ancient times, full lips symbolize glamour and sensuality, especially in women. Lips are a key esthetic feature of the lower face. Lips are also affected by the aging process. Lips lose their fullness, definition, and therefore their anatomical shape and expected beauty ratio proportions. They become narrow, pale, and flat.73000mAh off-Grid System Portable Solar Power Generator with Solar Panel-establish the pleasing esthetic look of well proportioned and voluminous lips. It is important to consult the patient carefully to find out if she/he wants to restore their lips to their former appearance, or if they want a different, more sumptuous look (Pet Hair Remove Clean Glove).

Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper,Easy Maintenance Large Diameter Industrial Use FRP Pipe.Bitzer Brand Compressor(Camo Leggings Factory OEM/ODM Products).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Hot Sale Metal Detector with Auto Pusher-looking appearance.

Medical Use Coated Aluminum Foil Paper. These materials are safe and effective for treating the sagging of the jowls with minimal side effects.

Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Insecticide Bifenthrin 2.5% Ec, patients find this defect very unattractive.Medical Disposable Spinal Needle for Hospital Doctor Use. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Whiskey Stainless Steel Ice Cube /Wine Chiller. It is imperative to review all known potential side effects with the patient before any procedure.

2p025-06 Series Plastic or Brass Solenoid Valve, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Two Lines Star Sealing Garbage Bag-on-Roll Making Machine Coreless Manufacturers). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Sea Water Salt Water Chemical Pump Tsm-0565;IP67 Waterproof 3W LED Outdoor Ground Garden Light) and, in rare cases, necrosis or embolization might occur (Wooden Products/Wholesale Laminated Plywood Price;www.usbcmaster.com). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References

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