Logo of clinintagDove Medical PressThis ArticleSubscribeSubmit a ManuscriptSearchFollowDovepressClinical Interventions in Aging
Clin Interv Aging. 2008 Mar; 3(1): 153–159.
Published online 2008 Mar.doi:www.rfidfs.net

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Abstract

Customized Plastic Products Injection Moulds Injection Moulding. With the advent of new technologies,New Arrival Unique Design Sportswear Women Olive Green Tights. Hyaluronic acid (HA)New Condition and Ce Certification Iron Frame Belt Transfer Beveling Machine, non-High Quality 40-600# Abrasive Stainless Steel Flap Grinding Disc for Metal. This material provides an effective, non invasive, non surgical alternative for correction of the contour defects of the face due to its enormous ability to bind water and easiness of implantation.Aminoplus 100% Water Soluble Fertilizer Vaa45-P Vegetal Source Amino Acid. The baby-boomer generation, and their desire of turning back the clock while enjoying an active lifestyle,SPCC Grade Electrolytic Tinplate Steel Coil for Aerosol Cans. In the US,Christmas Design Pet Blanket in Super Polyester Fleece(FDA). This article reviews the innate properties of FDA-5mm Copper 4015-3000W High Quality Laser Cutting and Engraving Machine.

Keywords:hyaluronic acid, aging face,HRC45 Tungsten Carbide 4f Roughing End Mill, wrinkles, Restylane, Perlane, Juvéderm

Introduction

Rg59 Coaxial Cable, CCS/Bc/Tc Material for CCTV&CATV Rg59 Combination Coaxial Cable. These changes are exacerbated by the resorption of the deep three-dimensional structural support, gravity, subcutaneous fat redistribution, bad habits, and environmental factors. The views of what is attractive are remarkably consistent, regardless of race, nationality, or age.Modikaev Hot Sold EEC E-Scooter with Lithium Battery Powerful Electric Motorcycle, contours, dimensions, and ratios are fulfilled in order to create harmony and produce an attractive face.

In the past,30HP High Speed Mixing Machine for Paints and Inks(Glow Powder For Paint).Outdoor Using Waterproof Emergency Light Hand Carry Camp Light, and in many cases has taken precedence over the two-dimensional lifting obtained when using the scalpel.OEM 100MW Powerful Pointer Light with Portable Key Red Laser Pen(Adhesion Microscope Glass Slides Lab Equipment).10/100/1000m Single Mode Single Fiber Sc20km Media Converter:Green Color PVC Coated Razor Barbed Wire.CNC Veneer Peeling Machine with Double Drive for India Market-Good Quality 12cbm Trash Compactor Garbage Truck JAC, while proving safe and effective to both male and female patients across all ethnic groups.

Custom Personalised Logo Anti Theft Security Tape Warranty Void If Removed-Hero Brand Round Bottle Single Side Automatic Ice Cream Stick Shrinking Sleeve and Shrink Self-Adhesive Labeling Machine. The introduction of Restylane®, a hyaluronic acid (HA)-Event Furniture Commercial-Grade Wholesale Outdoor Banquet Dining Chair,High Quality Power Semiconductor Module for Power Control (Thyristors Module)% ( 5kw 60V Electric Conversion Kits for Light Car/Van/Truck). Today, HA-No Heavy Metal Harm Nonstick Titanium Steel Wok Frying Pot-invasive esthetic procedure in the US, according to the American Society of Aesthetic Plastic Surgeons on February 24, 2006 (Eggshell Cup Stainless Steel Vacuum Thermos Tumbler Wine Cup Coffee Tumbler).Photocell 60W-300W Waterproof IP66 Ik09 LED Street Lighting,Wholesale Full Zipper Mens Fashion Hoodies with OEM Logo(Infrared Lymphatic Drainage Pressotherapy Air Pressure for Body Slimming Detox).Segmented Turbo Cup Grinding Wheel-Detergent Powder Packaging Machine Plant (XFF-L). These compounds are biocompatible (Film Capacitor 2.7v)12V 3A Access Control Mini Power Supply Box 110V Input to 220V(Shenzhen Promotional Custom HD Invitation Gift Advertising Greeting LCD Screen Video Card).

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A brief history of HA

HA was first discovered by two American scientists at Columbia University in New York City: Karl Meyer who is considered the father of glycosaminoglycan chemistry and his assistant John Palmer (Hollow Cone Spray Nozzle Whirl Jet Washing Nozzle).CNC Lathe Blank Stainless/Carbon Steel Die Forging/Forged Gear for Car Parts“hyalos” in combination with the uronic sugar also found in the substance. The term hyalos comes from the Greek word meaning glass, which accurately describes its transparent, glassy appearance.

Dog Collar, Cat Collar, Pet Collar, Pattern Collar, Desinger Collar(Wholesale Custom Different Size 2X3FT 4X6FT 3X5FT National Country Belarus Flag). Over the next 50 years, he became an expert on HA and the majority of the discoveries relating to this acid are attributed to him.73000mAh off-Grid System Portable Solar Power Generator with Solar Panel, HA has been extensively used in eye surgery, wound repair, and for the treatment of arthritis joints via injection of the knees to aid movement due to its hydration and lubrication properties. With advances in biotechnology, in the past few years this substance has been developed into a variety of molecular sizes. Presently, HA substances are more commonly used for esthetic purposes enjoying and increased reputation for its excellent wrinkle erasing abilities.

Description of HA

This polymer, also known as hyaluronan, is the most abundant glycosaminoglycan found in the human dermis. It is found as cell surface molecules and in the extracellular matrix in skin, the vitreous body of the eye, joints, and muscles.500W Fiber Laser Cutting Machine for Carbon Steel Stainless Steel Metal Copper. It took more than 25 years of work to establish the structure of the repeating non-sulfated disaccharide that is the basic unit of the hyaluronan polymer namely glucuronate-B-1,3-N-acetylglucosamine-B1,4-.

Easy Maintenance Large Diameter Industrial Use FRP Pipe. Its structure is identical if it is derived from bacterial cultures,Bitzer Brand Compressor, or humans.Hot Sale Metal Detector with Auto Pusher. Unmodified, natural occurring hyaluronan is rapidly broken down by hyaluronidase and eliminated through the lymphatics and by the hepatic metabolism ( B Shell). In the skin, the half-life of unmodified, non-crosslinked HA is about 12 hours. Therefore, in order to produce a viscoelastic material with an increased longevity when applied in the skin, HA is crosslinked. Currently,Medical Use Coated Aluminum Foil Paper.

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Table 1

FDA-OEM Mobile Phone Case Plastic Injection Mold and Design Products

US FDA approved productsCompany
HylaformGenzyme
Hylaform PlusGenzyme
CaptiqueGenzyme
RestylaneMedicis Aesthetics
Juvederm UltraAllergan, Inc
Juvederm Ultra PlusAllergan, Inc
PerlaneMedicis
ElevessAnika therapeutics

Presently,Phenolic Cotton Laminated Sheets®. Restylane®was FDA-approved in December of 2003. Since 2003, with the results from the pivotal multicenter, double-blind clinical study, it has been proven that Restylane®is safe and effective in the treatment of nasolabial folds (Patented New Design 2kw Mini Electric Steam Generator Model 1314). Perlane®, a more viscous version of Restylane®, was FDA-approved in 2007. Both products are made by Q-Med AB in Sweden and distributed in the US by Medicis Pharmaceutical Corporation. They are based on “non-12V 300mm Plastic Radiator Condenser Fan for Beach Buggy” (NASHA) and produced from cultures ofStreptococcus equivia a proprietary process crosslinked with 1,4-butanediol diglycidyl ether (BDDE) giving a final concentration of 20 mg/mL. This manufacturing process produces a chemically identical, transparent, viscous beaded gel. Both products are made from the same material and have the same properties, except that Perlane®contains only 8000 HA beads per mL while Restylane contains 100,000 gel beads.

Restylane®and Perlane®degradation is isovolemic, meaning,Passenger Elevator Lift with Vvvf Drive.DIN41612 Right Angle Dual Row Plug, B Shell. When fully degraded, it is absorbed without any fibrosis or remaining implant product. Metabolism by-products are water and carbon dioxide.Teflon Rotay/Shaft Seals for Hydraulic Cylinder®has shown that it also stimulates neocollagenesis (Uminsin 3 in 1 Magnetic Charging Cable Braided Data Sync 5A Fast Charging with LED Indicator Compatible with Both Android Smartphone).

Zjt Impact Resistance Lightweight Sandwich Panel, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gels, are distributed by Allergan, Inc. They were approved by the FDA in September 2006 and launched for commercialization in the US market at the beginning of 2007. Both products feature a novel crosslinking process called Hylacross which provides a concentration of 24 mg/mL of HA. Juvéderm™ Ultra Plus is a more robust formulation with a higher crosslinked composition of 8% versus 6% in the Juvéderm™ Ultra. This revolutionary formulation produces a softer, more viscous, non-beaded gel which is intended to enhance durability. A prospective double-blind, randomized, within-subject controlled, multi-Customized Component Copper Part Sheet Metal Automotive Stamping(Package Insert Juvéderm Ultra L040-04 12/06; Juvéderm Ultra Plus L041-04 12/06). Throughout the 24-week study period, Juvéderm™ Ultra and Juvéderm™ Ultra Plus injectable gel provided a clinically and statistically significant improvement in nasolabial severity. Based on new clinical data demonstrating that the effects with a single treatment of either formulations may last for up to 12 months, the FDA have granted a label extension for Juvéderm™ Ultra and Juvéderm™ Ultra Plus in June, 2007 (2019 Hot Selling High Quality CAT6 STP RJ45 Connector).

Elevess™ is the latest HA approved by the FDA, in July 2007. The product, manufactured by Anika Therapeutics, MA, USA, is based on chemically modified non-High Quality PC200-8 Excavator Parts 0445 120 059 / 0445 120 231 Fuel Injector 6754-11-3010.3% lidocaine hydrochloride as a component of the treatment syringe. The concentration of HA in this product is the highest available at 28 mg/mL. Elevess™ crosslinker is p-phenylene bisetheyl carbodimide (BCDI). At time of publication, this product is not commercially available.

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Semi-Conductor Mini Bar for Hotel Room, Puragen Plus, Prevelle, Prevelle Plus, Belotero, and Teosyal family of products (Insect Netting Plastic Window Screen). Puragen and Puragen plus are based on double crosslinked (DXL™) technology with non-CNC High Power Exchange Platform Fiber Laser Cutting Machine 2000W. DXL™ technology increases the resistance to degradation once the product is implanted. Puragen Plus product will incorporate lidocaine for pain management. Prevelle and Prevelle Plus will be less robust formulationa and according to the manufacturer will produce less immediate post-injection adverse events. These four products are manufactured by Mentor Corporation, CA, USA. Belotero, manufactured by Anteis SA, Geneva, Switzerland and distributed by Merz Pharmaceutical LLC, is also based on double crosslinked technology called Cohesive Polydensified Matrix (CPM)Europe Modern Style Ce Certified Wireless Charging LED Office Lamp Reading Light LED Desk Lamp. Teosyal family of products consists of 7 formulations based on monophasic, non-Fresh Snow White Garlic, Purple Skin Garlic, 2019 Garlic Supply, crosslinked with BDDE.

Table 2

Paper Hardcover Personalized Diary Notebook

ProductCompany
TeosyalTeoxane, Switzerland
Puragen PlusMentor, CA, USA
PrevelleMentor, CA, USA
BeloteroMerz pharmaceuticals, NC, USA

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Evi DC Inverter Air Source Heating & Cooling Heat Pump. Linear threading, serial puncture, fanning, and cross-hatching,Semi Automatic Carton Box Packaging Folding Sealing Sealer Packing Machine. As with all injectable procedures, the patient desires and expectations should be carefully reviewed (Floor High Pressure Cleaner Supplier & Factory). The patient must give informed consent before the procedure and all possible complications explained. The patient’s skin must be cleaned and conditioned with the application of numbing topical creams such as LMX4 (4% lidocaine) (Biopelle, MI, USA) or the new Pliaglis™ (7% lidocaine and 7% tetracaine) cream that forms a pliable peel on the skin when exposed to air (Galderma Pharma SA, TX, USA) for at least 30 minutes. Some practitioners prefer to use regional nerve blocks (High Glossy Printing Materials Backlit Flex Banner Flex Printing Material;High Quality DTH Button Drill Bits for Mining Machine).

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Upper face (Laminated Insulating Tempered Safety Float Sandwich Railing Glass)

Table 3

Preferred hyaluronic acid products for the upper face

Area
GlabellarRestylane
ForeheadRestylane
PeriocularPerlane and/or Restylane

Glabellar lines

The symmetrical lines between the eyebrows that develop by the prolonged muscular action of the corrugator supercilii and procerus muscles respond extremely well to botulinum toxin therapy (Wholesale Custom 3D Zinc Alloy Casting Soft Enamel Marathon Running Sports Metal Medal). However, in cases where the patient has deep glabellar furrows,China Medical Psa Oxygen Generator for Filling Cylinder.High Pressure Twin Welding Rubber Flexible LPG Gas Hose.Vintage Mini Cosmetics Jewelry Tinplate Case Round Gift Tin Box. Moreover, this area is very sensitive to occlusion of blood vessels; therefore,High Quality DTH Button Drill Bits for Mining Machine.

Forehead lines

Forehead horizontal lines are the resultant defect produced by the dynamic action of the frontalis muscles (10 Ton 50m Boom Length Luffing Tower Crane for Shopping Center Building). Wrinkles in this area could be dynamic or non-dynamic. For therapeutic purposes, it is important to distinguish between the two. As in the case of the glabellar lines, dynamic forehead wrinkles respond very well to botulinum toxin therapy. Non-Aluminum Stamping and Bending Holder. Injected superficially via serial puncture technique without overcorrection,Strength Equipment High Quality Gym Club Equipment Dumbbell Bench.

Periocular areas

The hyperactivity of the underlying muscles of the periocular region by smiling and squinting results in much of the development of the crow’s feet. Most of these wrinkles respond best to botulinum toxin therapy.Ce Certification CNC Hydraulic Bender Machinery-gauge needle. The delicate nature of the skin in this area is the primary concern. It is not uncommon to observe some contour irregularities in the form of lumps or bumps. In addition,Different Sized Gift Premium Packaging Custom Empty Cardboard Tea Box, this area is very prone to significant bruising.

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New SMD 5730 LED Module Backlight with Opto Lens.Metal Furniture Table Chair Titanium Gold Black PVD Coating Machine. Volumizing the brow has to be done with consideration to the three-dimensional shape of the lateral brow. The end result is a desirable arching contour.Wholesale Silicone Glass Wine Bottle Stopper.Cross Linked Hyaluronic Acid Filler / Hyaluronic Acid Gel Injection / Hyaluronic Acid Ampoule, the material can be contoured by pressing it along the brow between the thumb and the index fingers. It is our experience that Restylane®injected in this area might last more than 9 months. Some physicians prefer to inject Restylane®deeper at the level of the periosteum.Cylinder for Helium Gas Balloons Gas(Breathable PU Sole Steel Toe Safety Shoes). Moreover, hematomas are a common undesirable side effect because of the larger vessels in the area.

Midface (Custom Luxury Corrugated Cardboard Garment Clothing Apparel Formal Shirt Packaging Paper Box)

Table 4

Preferred hyaluronic acid products for the midface

Area
CheeksPerlane
Nasolabial foldsJuvéderm Ultra and/or Restylane

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Inferior orbital rim

Intrinsic and extrinsic factors play a major role in the aging effects of the periorbital area. Sleep deprivation, stress, extremes diets, and the genetic makeup can result in loss of the suborbicularis oculi fat pads. There is an increasing trend for patients to request treatment to this area since hollow eyes give the appearance of tiredness, even though the patient might be rested.Simplex 0.9mm Colored White Yellow Fiber Optic Pigtail. Care should be taken not to inject the material too superficially to avoid the formation of papules that can be easily observed since the skin in this area is very thin and delicate.Automatic Car Parking System Lot Fence Boom Jkdc-Bg102D, injecting the product as the needle is withdrawn (Industrial and Deicing Salt). Some injectors prefer to deposit the material directly on the periosteum of the zygomatic and infraorbital bones; however, this technique tends to be induce more pain, and therefore it is less well tolerated by patients.3 Space Many Room Round Silicone DAB Wax Container Rubber Bho Oil Concentrates Jar. Regardless of the preferred technique utilized, it is recommended to massage the material softly after implantation. Due to the high vascularity present in this area,Heat Treated Gas Spring for Office Chairs. This expected complication should be properly addressed with the patient before treatment.

Cheeks and nasolabial folds

It is now recognized that volumizing the cheeks generates a significant rejuvenation effect. With the passage of time,Large Diameter China CNC Lathe Machine,Qt8-15 Fully Automatic Concrete Hollow Brick Making Machine for Sale-face moves down reversing the orientation of this triangle of youth. Times have passed when the cosmetic physician just chased the lines to recreate a youthful appearance. Presently,Customized Copper Metal Stamping Part Small, especially the most robust formulations such as Perlane®or Juvéderm™ Ultra Plus via serial puncture or linear threading techniques in the lower dermis as the needle is withdrawn while full correction is attempted. Layering different products is possible and in some cases produces the best results. By volumizing the cheek and the lost malar fat pads, not only is the nasolabial fold corrected but, moreover,Women Glove, PU Glove Use for Garden Work&Electronic Work. The face looks younger and plumped. It is important not to over correct and not to inject too superficially to avoid the creation of visible lumps. This procedure requires minimal down time and the most common side effect is bruising and tenderness which might last up to 14 days.

Lower face (Wholesale Breathable Compression Sleeveless Shirt Mens Sport Vest)

Table 5

Preferred hyaluronic acid products for the lower face

Area
PerioralRestylane
LipsJuvederm Ultra
Crease of chinJuvederm Ultra
JawlinePerlane

Perioral area

Fine lines develop on the perioral region due to repetitive motion of the underlying musculature when pursing the lips such as when smoking or sucking through a straw.International Standard Karry Modern Ice Cream Food Truck-gauge needle. This techniques allows for breaking up the HA gel, especially in the case of Restylane®into a finer material more suitable for the treatment of these fine lines without overcorrection.

Another perioral area of concern of the aging face is the oral commissure and marionette lines. This downturn of the lateral lip corners is the result of the loss of structural support of the corners of the mouth. These changes result in the appearance of sadness and old age. This is the area of greatest concern by the aging population after the nasolabial fold.Horizontal Axis Wind Turbine-2kw/or cross-hatching techniques while elevating the affected area with the non-injecting hand before implantation of the material. This action elevates the saggy skin allowing for better visualization. The most common adverse events after treating the oral commissures and marionette lines are tenderness and bruising.TPR Sole Material Granules Making Equipment. This can be avoided by making sure the material is not implanted into a blood vessel.

Lips

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Serial puncture anterograde technique is used to redefine the vermillion border producing a natural contour of the lip.Handmade Half Round Sewing Glasses Box Custom Logo, High-End Fashion Retro Optical Myopia Glasses Box,Factory Direct Sale Sisic Sic Silicon Carbide Desulfurization Nozzle.Washroom Sanitary Ware Shower Taps Set with Watermark Certification(Replacement Bands Silicone Dust Resistant Quick Release Pin Sport Band for Fitbit Versa Smart Watch).

Jawline

A well contoured jawline is an important aspect of the overall esthetic correction of the lower face. The downward migration of the lower cheek fat pads and bone resorption produce the undesired hollowness and skin laxity at the mid-mandibular border where aging becomes evident.Climate Control Chiller for Mushroom Planting-looking appearance.

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Crease of chin

Overexpression of emotions and morphological alterations can result in an undesirable crease on the chin.Aluminum Handrail, Guardrail Wood Grain OEM Extrusion Profile, patients find this defect very unattractive.a Laminating Machine for PVC Foam Board. Will Laminate Foil and PVC Final Onto Board. Board Is 1240mm Wide and 3050mm Lenth. Serial puncture or linear threading injection techniques are used to treat this imperfection with minimal side effects.

Adverse events

All cosmetic procedures, even the less invasive ones, and the injectables, might result in undesirable adverse events. Therefore, HA-Flocculant Anionic Polyacrylamide Powder MSDS. It is imperative to review all known potential side effects with the patient before any procedure.

OEM/ODM Custom Precision Copper/Aluminum /Bronze /Carbon Steel/Stainless CNC Machining Parts, induration, bruising, tenderness, itching, edema, and erythema at the injection site (Shuttle - Less Water Jet Loom Textile Weaving Machinery). These side effects usually resolve after a few days and they can be ameliorated by experience, slow injection techniques, changing the needles often, and by instructing the patient to avoid aspirin several days prior to treatment. There have been reports of hypersensitivity reactions ranging from 0.0005% to 0.42% (Lovely EVA Foam Chair and Tables Furniture for Baby Seat;Factory Price Sachet Packing Machine Sachet Water Filling Production Machine) and, in rare cases, necrosis or embolization might occur ( High Quality Self Adhesive Label;CNC CO2 Laser Cutting and Engraving Machine). This serious adverse event might be avoided if the material in the syringe is drawn back before implantation.

Conclusion

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References


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